research associate professor
Supervisor: VERES, Balázs
Co-supervisor: KÁLMÁN, Nikoletta
Sepsis is one of the leading causes of death in intensive care units affecting more than 18 million people worldwide. Although precise mechanisms by which sepsis leads to multiple organ dysfunction are unknown, growing evidence suggests that blocking the main inflammatory signaling pathways might be a strategy to control the pathophysiology of sepsis. Nuclear factor-κB (NF-κB) as one of the most important inflammatory transcription factors plays a crucial role in regulation of uncontrollable inflammatory processes leading to sepsis. Naturally abundant biomolecules with significant anti-inflammatory effect (e.g. polyphenols) are in the limelight of our studies. We focus on the effect of these biomolecules on enzymes and adaptor proteins in signaling pathway between the cell surface TLR4 receptor and the NF-κB transcription factor.