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KOLTAI, Katalin

KOLTAI, Katalin

senior lecturer

1st Department of Medicine

Phone: 32624, *0985

Supervisor of the following TDK topics

Supervisor: KOLTAI, Katalin

Rheological factors and increased platelet aggregation are convincingly implicated in the development of micro- and macrovascular diseases associated with diabetes mellitus. Glycemic control seems to be a major factor to  determine the hemorheological consequences of diabetes. Positive associations have been found between parameters of glycemic control, fibrinogen levels and red blood cell aggregation; fibrinogen levels are also correlated to insulin resistance. The binding of fibrinogen to the GP IIb-IIIa receptor is increased in diabetic patients; and they also have a higher ratio of platelets expressing activation-dependent adhesion molecules such as activated GPIIb-IIIa, lysosomal Gp53, thrombospondin and P-selectin; plasma fibrinogen levels are also increased in diabetes. Platelets may interact with glycosylated low density lipoproteins, von Willebrand factor or immune complexes, and platelet turnover may be shortened in diabetes, thereby contributing to the observation that antiplatelet agents such as aspirin and clopidogrel have a diminished effect in these patients. We aim to study the effects of impaired glucose metabolism on hemorheological parameters, platelet activation and aggregation in patients treated with different antidiabetic regimens. 

Supervisor: KOLTAI, Katalin

Co-supervisor: Dr. TÓTH, András

Chronobiology is the scientific discipline concerned with the definition, mechanisms, and significance of the so-called time structure of life forms. Seasonal variations in death rates with the highest levels occurring during the colder winter months have been described in many countries. Cardiovascular disease related deaths account for the majority of excess winter deaths.  Circannual rhythms have been described in parameters as fibrinogen, hematocrit, platelet count, hormones, serum lipids, and glucose. We aim to investigate whether hemorheological parameters and platelet aggregabiliy show seasonal differences in a population with established vascular disease. We plan to investigate a possible association with certain meteorological factors as ambient temperature, daily amount of sunshine hours, relative humidity and simultaneous changes in air pressure.

Supervisor: KÉSMÁRKY, Gábor

Co-supervisor: Dr. KOLTAI, Katalin

Peripheral artery disease (PAD) is the progressive stenosis, occlusion or aneurysmatic dilatation of the aorta and its non-coronary vessels. Until now the medical care of PAD has been in the background compared to coronary artery disease (CAD) or cerebrovascular disease, despite that the number of limb amputation is 3-4 times higher compared to Western-Europe, meaning that most of these procedures can be prevented. Screening and diagnosis of PAD is important, because only 10% of PAD-patients have the well-known claudication intermittens. PAD also has a negative prognostic value: 55% of them die due to CAD. In our study we measure tissue oxygen tension and hemorheological parameters in PAD and also monitor their changes during treatment in order to find the most effective therapy.

Supervisor: KOLTAI, Katalin

Co-supervisor: Dr. ENDREI, Dóra

Venous thromboembolism (VTE) includes deep vein thrombosis and pulmonary embolism. VTE is a common, potentially fatal, often recurring disease. As a complication, infarct pneumonia, chronic venous insufficiency, pulmonary hypertension, ulcus cruris, and disability can occur. The importance of VTE is not only a health issue but also of economic importance, with frequent complications leading to chronic conditions. The risk of developing the first VTE increases with age. The risk of recurrence depends on the etiology in patients who previously underwent VTE. It is highest in patients with unprovoked VTE or in patients with a high risk thrombophilia. The aim of our study is to assess the symptoms, diagnosis, risk factors, therapy, and follow-up of our VTE patients both in inpatient and outpatient care in regard to the appearance of complications.

Supervisor: KOLTAI, Katalin

Co-supervisor: Dr. ENDREI, Dóra

Venous thromboembolism (VTE) includes deep vein thrombosis and pulmonary embolism. VTE is a common, potentially fatal, often recurring disease. As a complication, infarct pneumonia, chronic venous insufficiency, pulmonary hypertension, ulcus cruris, and disability can occur. The importance of VTE is not only a health issue but also of economic importance, with frequent complications leading to chronic conditions. The risk of developing the first VTE increases with age. The risk of recurrence depends on the etiology in patients who previously underwent VTE. It is highest in patients with unprovoked VTE or in patients with a high risk thrombophilia. The aim of our study is to assess the symptoms, diagnosis, risk factors, therapy, and follow-up of our VTE patients both in inpatient and outpatient care in regard to the appearance of complications.

Supervisor: KÉSMÁRKY, Gábor

Co-supervisor: Dr. KOLTAI, Katalin

A significant part of the population suffers from peripheral arterial diseases but the awareness of these diseases is much lower, the secondary prevention and even the symptomatic treatment are inappropriate frequently compared to the cardiovascular disorders. Therefore we are aiming to investigate those factors which can affect the blood and oxygen supplementation of the extremities performing cardiological, angiological, haemorheological and tissue oxygen tension examinations in order to be able to salvage the limbs and improve life quality. We examine the effects of the various pharmacological and non-pharmacological therapies on these variables and limb survival.

Supervisor: KÉSMÁRKY, Gábor

Co-supervisor: Dr. KOLTAI, Katalin

Non-invasive angiological tests in patients at high risk for peripheral artery disease