M.D. Ph.D. Dsc.
full professor , chair
Supervisor: ÁBRAHÁM, István
Co-supervisor: Dr. KÖVESDI, Erzsébet
Estrogen secreted from the ovary alters the function of several neuronal phenotypes. Cholinergic neurons degenerate in Alzheimer's disease and estrogen plays a role in determining the vulnerability of cholinergic neurons in this condition. The estrogen also acts a feedback manner to alter the function of gonadotropin releasing hormone (GnRH) neurons, the central "processor unit" of the fertility. Although estrogen primarily alters the neuronal activity by modulating gene expression directly it also exerts "non-classical" effects on neurons by altering signal transduction pathways. In our laboratory, we are systematically characterizing the mechanism and role of estrogen-induced "non-classical" effect on signalling molecules in cholinergic and GnRH neurons using immunohistochemistry, calcium imaging, single cell electrophysiology, single molecule detection, bahavioural tests and transgenic technology.