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HORVÁTH, Ádám István

HORVÁTH, Ádám István

Supervisor of the following TDK topics

Supervisor: HELYES, Zsuzsanna

Co-supervisor: Dr. HORVÁTH, Ádám István

Amino-oxidases neutralise the pharmacological effects of exogenous and endogenous biogen amines. However, their reaction products (aldehyde, hydrogen-peroxide, ammonia) are biologically active, potentially toxic compounds. Although the substrate-specificity of these enzymes and their sensitivity to enzyme inhibitors is well-known, their physiological and pathophysiological role is not cleared yet. Therefore, as a continuation of our former experiments, we investigate their function in neuropathic, postoperative and inflammatory pain conditions.

Supervisor: HELYES, Zsuzsanna

Co-supervisor: Dr. HORVÁTH, Ádám István

TRPA1 and TRPV4 receptors are expressed on capsaicin-sensitive sensory neurons, immune cells and keratinocytes. TRPA1 receptors are activated by pungent agents (mustard oil, cinnamaldehyde), exogenous and endogenous toxic chemicals, as well as inflammatory mediators and noxious cold (<17°C). The activation and sensitization mechanisms and interactions of TRPV4 are less known. Therefore, we aim to analyze their roles and cross-talks in inflammatory and neuropathic pain models with thermo- and mechanonociceptive testing methods using gene-deleted mice pharmacological interventions.