Supervisor: KISS, Péter
Co-supervisor: Dr. HORVÁTH, Gábor
Nowadays enriched environment is a frequently investigated topic. Based on a review released in 2009: in the future, environmental enrichment could be an emphasized-strategy as a widely used therapeutic intervention or could work as a combination together with other neuroprotective strategies. Based on the previously mentioned points further examination of environmental enrichment is necessary. It is already confirmed that enriched environment increases the synaptic plasticity and neurogenesis, increases the number of dendritic spines and stimulates the expression of neurotrophic factors. It also positively affects the cognitive functions. For this experiment we made a dynamically changing playground for the animals. Several studies prove that enriched environment could help in lesions not only newborn and childhood ages, but adulthood as well. In toxic, hypoxic and traumatic models the positive effects of the environmental enrichment already described. We will use different animal models to follow up how long does environmental enrichment last for as a reserve capacity of central nervous system in case of lesions and how can it modify the effects of well-known neuroprotective agents.