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« Research

Student Researchers' Society Topics

The chronic complications of diabetes mellitus include besides the vascular complications also an increased risk of malignancies. Using a literature survey, we review the cancer risk and the incidence of individual malignancies in diabetic and non-diabetic patients. Also, we review the effect of antidiabetic therapies and medications on the risk of cancer.

The chronic complications of diabetes mellitus include large-vessel damages. Using a literature survey, we review the cardiovascular risk, the affection of individual organs in diabetic and non-diabetic patients. Also, we review the effect of antidiabetic therapies and medications on cardiovascular risk.

The proximal tubular cells of the kidney play an important role in the reabsorption of physiologically important substances, such as glucose, electrolytes and amino acids from the primary filtrate. These processes can be damaged in acute and chronic tubular diseases, leading to electolyte disturbances, aminoaciduria and renal glucosuria. In patients treated with a potential tubular dysfunction, using an HPLC-sstem we evaluate the serum level and urinary excretion of certain amino acids (phenylalanine, para-/meta-/ortho-tyrosine) and their connection with markers of glomerular and tubular function.

Oxidative stress processes can lead to the formation of oxidized amino acids (e.g. meta- and ortho-tyrosine – m-Tyr and o-Tyr) from physiological amino acids (eg. phenylalanine - Phe). These amino acids can be formed by the conversion of protein-bound Phe residues or free Phe molecules. The resulting m- and o-Tyr can alter the structure and thus the function of proteins. We investigate the role of m- and o-Tyr in the development of insulin- and erythropoietin-resistance.