1 October 2013
16th October 2013, 12.00, Szentagothai Research Centre B 001
It is our pleasure to invite you to
Prof. John P. Quinn's (chair of Neurobiology, Institute of Translational Medicine, University of Liverpool) lecture on
The 'yin and yang' of the dynamic genome in shaping human behaviour
It will be discussed how the opposite dynamics of genome structure, such as the most conserved and the most rapidly evolving regions of non-coding DNA are complementing one another to generate the functional diversity observed in human behaviour, mental health and wellbeing by altering the transcriptome in specific cell types. Analysis of polymorphism in such domains in a variety of diseases can now give us information on our likely hood of predisposition to a particular disorder. However the genetic bias is not absolute and we shall discuss that in term of the 'Nature v Nurture' model and how that can also alter the epigenome to modify these transcriptome profiles.
Dr. Christopher Murgatroyd's (lecturer, School of Healthcare Science, University of Liverpool) lecture on
Epigenetic programming of neuroendocrine systems during early life.
Animal models, in which early environmental factors are manipulated in a controlled manner, are demonstrating that adverse conditions in early life can program long-lasting behavioural changes that associate with the alteration of key neuroendocrine circuits underlying emotional functions and endocrine responses to stress. Specifically, maternal separation and disrupted maternal care in rodents during early life lead to programming of long-term changes in the regulation of the genes coding for neuropeptides. Particularly, it is argued that epigenetic mechanisms including DNA methylation and chromatin remodelling can mediate the gene-environment dialog in early life and give rise to persistent changes in behaviour.