Iron Metabolism: from Molecular Mechanisms to Clinical Consequences

Daten

Offizielle Daten in der Fachveröffentlichung für das folgende akademische Jahr: 2023-2024

Thematik

During the course we will discuss the role of iron in the metabolism. We will deal with the iron demand of microorganisms and with the role of iron in the protective mechanisms against bacterial infections. The function of influencing factors of iron metabolism, their effects and crosstalk between them will be discussed in detail. The roles of iron containing proteins and their functions will be talked over. During the course we will emphasize the disorders of iron metabolism (iron deficiency, iron overload), their genetic backgrounds and their therapies. Based on the most actual findings the role of iron in the development of neurodegenerative diseases (Parkinson's disease, Alzheimer's disease and Huntington's disease) will be also discussed.

Vorlesungen

Praktika

Seminare

• 1. Solution chemistry of iron, interactions with other metal ions.
• 2. The Importance of Iron for Biological Systems: haemoproteins, iron-sulfur proteins, other iron containing proteins
• 3. Microbial Iron Transport and Metabolism
• 4. Iron uptake by yeasts
• 5. Cellular Iron Uptake and Export in Mammals: iron transporters
• 6. Intracellular Iron Storage and Biomineralisation: ferritin, haemosiderin
• 7. Intracellular Iron Metabolism and Cellular Iron Homeostasis I: Labile iron pool, mitochondrial iron uptake and metabolism haem biosynthesis
• 8. Intracellular Iron Metabolism and Cellular Iron Homeostasis II: synthesis of iron-sulfur clasters, functions of iron responsive elements and iron regulatory proteins
• 9. Iron Absorption in Man: functions of luminal factors, regulation of Systemic Iron Balance
• 10. Pathophysiology of Iron Deficiency: anemias, thalassemias
• 11. Iron disorders and Laboratory parameters
• 12. Iron and oxidative stress: cytoprotective enzymes, antioxidants, aging, role of the immune system
• 13. Brain iron metabolism, the role of iron in neurodegenerative diseases
• 14. Pathophysiology of Iron overload: hemochromatosis

Materialien zum Aneignen des Lehrstoffes

Obligatorische Literatur

Vom Institut veröffentlichter Lehrstoff

The educational materials will be uploaded to Neptune MeetStreet

Skript

Empfohlene Literatur

Robert Crichton: Iron Metabolism: From Molecular Mechanisms to Clinical Consequences

Voraussetzung zum Absolvieren des Semesters

Max. 3 absences

Semesteranforderungen

Three tests with one possible retake.

Möglichkeiten zur Nachholung der Fehlzeiten

Personal consultation

Prüfungsfragen

Simple choice test based on the seminars.

Prüfer

Praktika, Seminarleiter/innen

• Dr. Pandur Edina
• Jánosa Gergely
• Pap Ramóna