Daten
Offizielle Daten in der Fachveröffentlichung für das folgende akademische Jahr: 2023-2024
Lehrbeauftragte/r
-
Dr. Edina PANDUR
assistant professor,
Department of Pharmaceutical Biology -
Semesterwochenstunden
Vorlesungen: 0
Praktika: 0
Seminare: 14
Insgesamt: 14
Fachangaben
- Kode des Kurses: OAF-VAA-T
- 1 kredit
- General Medicine
- Optional modul
- spring
OAA-MB2-T completed
Zahl der Kursteilnehmer für den Kurs:
min. 4 – max. 24
Erreichbar als Campus-Kurs für 10 fő számára. Campus-karok: ETK GYTK TTK
Thematik
During the course we will discuss the role of iron in the metabolism. We will deal with the iron demand of microorganisms and with the role of iron in the protective mechanisms against bacterial infections. The function of influencing factors of iron metabolism, their effects and crosstalk between them will be discussed in detail. The roles of iron containing proteins and their functions will be talked over. During the course we will emphasize the disorders of iron metabolism (iron deficiency, iron overload), their genetic backgrounds and their therapies. Based on the most actual findings the role of iron in the development of neurodegenerative diseases (Parkinson's disease, Alzheimer's disease and Huntington's disease) will be also discussed.
Vorlesungen
Praktika
Seminare
- 1. Solution chemistry of iron, interactions with other metal ions.
- 2. The Importance of Iron for Biological Systems: haemoproteins, iron-sulfur proteins, other iron containing proteins
- 3. Microbial Iron Transport and Metabolism
- 4. Iron uptake by yeasts
- 5. Cellular Iron Uptake and Export in Mammals: iron transporters
- 6. Intracellular Iron Storage and Biomineralisation: ferritin, haemosiderin
- 7. Intracellular Iron Metabolism and Cellular Iron Homeostasis I: Labile iron pool, mitochondrial iron uptake and metabolism haem biosynthesis
- 8. Intracellular Iron Metabolism and Cellular Iron Homeostasis II: synthesis of iron-sulfur clasters, functions of iron responsive elements and iron regulatory proteins
- 9. Iron Absorption in Man: functions of luminal factors, regulation of Systemic Iron Balance
- 10. Pathophysiology of Iron Deficiency: anemias, thalassemias
- 11. Iron disorders and Laboratory parameters
- 12. Iron and oxidative stress: cytoprotective enzymes, antioxidants, aging, role of the immune system
- 13. Brain iron metabolism, the role of iron in neurodegenerative diseases
- 14. Pathophysiology of Iron overload: hemochromatosis
Materialien zum Aneignen des Lehrstoffes
Obligatorische Literatur
Vom Institut veröffentlichter Lehrstoff
The educational materials will be uploaded to Neptune MeetStreet
Skript
Empfohlene Literatur
Robert Crichton: Iron Metabolism: From Molecular Mechanisms to Clinical Consequences
Voraussetzung zum Absolvieren des Semesters
Max. 3 absences
Semesteranforderungen
Three tests with one possible retake.
Möglichkeiten zur Nachholung der Fehlzeiten
Personal consultation
Prüfungsfragen
Simple choice test based on the seminars.
Prüfer
Praktika, Seminarleiter/innen
- Dr. Pandur Edina
- Jánosa Gergely
- Pap Ramóna