Pharmaceutical Biology 1

Data

Official data in SubjectManager for the following academic year: 2023-2024

Topic

The 2-semester Biology course provides the essential fundamental molecular biological knowledge for the pharmaceutical students. In the first semester students will study the structure and main functions of the living eukaryotic cells. We will discuss briefly the structural features of prokaryotes as well as viruses. The majority of the topics will deal with the information storage and utilization of the cells, and the regulation of these processes.

Lectures

• 1. Introduction. - Dr. Sipos Katalin
• 2. Building blocks of the cell. - Dr. Sipos Katalin
• 3. Genom and gene expression. - Jánosa Gergely
• 4. Tools and techniques in molecular biology I. - Pap Ramóna
• 5. Tools and techniques in molecular biology II. - Pap Ramóna
• 6. Prokaryotic and eukaryotic cells. - Jánosa Gergely
• 7. Stem cells. - Dr. Poór Viktor Soma
• 8. The nucleus and the cellular membranes. - Jánosa Gergely
• 9. Structure of DNA. - Dr. Pandur Edina
• 10. Chromosomes and genomes. - Dr. Pandur Edina
• 11. Mitochondrium: structure and function. Mitochondrial DNA. - Jánosa Gergely
• 12. Cytoplasmic organelles: endoplasmic reticulum, Golgi apparatus, lysosomes. - Dr. Pandur Edina
• 13. Replication I. - Dr. Poór Viktor Soma
• 14. Replication II. - Dr. Poór Viktor Soma
• 15. DNA repair mechanisms. - Jánosa Gergely
• 16. Transcription in prokaryotic cells. - Dr. Sipos Katalin
• 17. Eukaryotic transcription: mRNA. - Dr. Sipos Katalin
• 18. Eukaryotic transcription: tRNA, rRNA. - Dr. Sipos Katalin
• 19. Regulation of transcription. - Dr. Horváth Adrienn
• 20. Transcription factors. - Dr. Pandur Edina
• 21. The genetic code. - Pap Ramóna
• 22. Structure and functions of ribosomes. tRNA - Dr. Pandur Edina
• 23. Steps of translation. - Dr. Pandur Edina
• 24. Protein analysing methods I. - Pap Ramóna
• 25. Protein analysing methods II. - Pap Ramóna
• 26. Gene regulation: prokaryotes. - Jánosa Gergely
• 27. Regulation of gene expression in eukaryotes I. - Dr. Horváth Adrienn
• 28. Regulation of gene expression in eukaryotes II. - Dr. Sipos Katalin
• 29. Posttranslational modifications. - Pap Ramóna
• 30. Degradation of proteins. - Pap Ramóna
• 31. Intracellular trafficing of proteins: nucleus, mitochondrion. - Dr. Sipos Katalin
• 32. Intracellular trafficing of proteins: ER. - Dr. Sipos Katalin
• 33. Intracellular trafficing of proteins: Golgi, lysosomes. - Dr. Sipos Katalin
• 34. Antibiotics. - Pap Ramóna
• 35. Cell cycle I - Jánosa Gergely
• 36. Cell cycle II - Jánosa Gergely
• 37. Mitosis I - Dr. Pandur Edina
• 38. Mitosis II - Dr. Pandur Edina
• 39. Meiosis I - Dr. Poór Viktor Soma
• 40. Meiosis - Dr. Poór Viktor Soma
• 41. Transport through biological membranes - Dr. Sipos Katalin
• 42. Consultation. - Dr. Sipos Katalin

Practices

• 1. Preparation of biological buffers (TE, loading, PAGE, DNA isolation solutions).

Seminars

• 1. Macromolecules as building blocks of living cells.
• 2. Separation techniques.
• 3. Detection in molecular biology.
• 4. Cytoskeleton.
• 5. Bases of PCR.
• 6. Sequencing methods.
• 7. Transcription: summary.
• 8. Viruses.
• 9. Human Genome Project.
• 10. Molecular biological methods in Pharmaceutical research.
• 11. Intracellular targeting: summary.
• 12. Mechanisms of antibiotics.
• 13. Consultation.

Reading material

Obligatory literature

Literature developed by the Department

The materials of the lectures and seminars will appear on Neptune.

Notes

Electronic note on Pharmaceutical Biology can be found on Neptun Meet Street.

Recommended literature

Cooper GM: The Cell: A Molecular Approach, 2nd edition, PubMed
Elliott WH, Elliott DC: Biochemistry and Molecular Biology, 3rd edition
Thompson & Thompson: Genetics in Medicine
Crai NL: Molecular Biology, Principles of Genome Function, OUP 2010
Young ID: Medical Genetics

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

There is no written midterm exam.

Making up for missed classes

According to personal agreement

Exam topics/questions

There are no given exam questions. The topics of the exam will be the materials of lectures and seminars.

Examiners

• Dr. Pandur Edina
• Dr. Sipos Katalin
• Jánosa Gergely
• Pap Ramóna

Instructor / tutor of practices and seminars

• Dr. Horváth Adrienn
• Dr. Pandur Edina
• Dr. Sipos Katalin
• Jánosa Gergely
• Pap Ramóna