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Education

Iron Metabolism: from Molecular Mechanisms to Clinical Consequences

Data

Official data in SubjectManager for the following academic year: 2023-2024

Course director

Number of hours/semester

lectures: 0 hours

practices: 0 hours

seminars: 14 hours

total of: 14 hours

Subject data

  • Code of subject: OXF-VAA-h-T
  • 1 kredit
  • General Medicine
  • Optional modul
  • spring
Prerequisites:

ODA-MB2-T completed

Course headcount limitations

min. 4 – max. 24

Available as Campus course for 10 fő számára. Campus-karok: ETK GYTK TTK

Topic

During the course we will discuss the role of iron in the metabolism. We will deal with the iron demand of microorganisms and with the role of iron in the protective mechanisms against bacterial infections. The function of influencing factors of iron metabolism, their effects and crosstalk between them will be discussed in detail. The roles of iron containing proteins and their functions will be talked over. During the course we will emphasize the disorders of iron metabolism (iron deficiency, iron overload), their genetic backgrounds and their therapies. Based on the most actual findings the role of iron in the development of neurodegenerative diseases (Parkinson's disease, Alzheimer's disease and Huntington's disease) will be also discussed.

Lectures

Practices

Seminars

  • 1. Solution chemistry of iron, interactions with other metal ions.
  • 2. The Importance of Iron for Biological Systems: haemoproteins, iron-sulfur proteins, other iron containing proteins
  • 3. Microbial Iron Transport and Metabolism
  • 4. Iron uptake by yeasts
  • 5. Cellular Iron Uptake and Export in Mammals: iron transporters
  • 6. Intracellular Iron Storage and Biomineralisation: ferritin, haemosiderin
  • 7. Intracellular Iron Metabolism and Cellular Iron Homeostasis I: Labile iron pool, mitochondrial iron uptake and metabolism haem biosynthesis
  • 8. Intracellular Iron Metabolism and Cellular Iron Homeostasis II: synthesis of iron-sulfur clasters, functions of iron responsive elements and iron regulatory proteins
  • 9. Iron Absorption in Man: functions of luminal factors, regulation of Systemic Iron Balance
  • 10. Pathophysiology of Iron Deficiency: anemias, thalassemias
  • 11. Iron disorders and Laboratory parameters
  • 12. Iron and oxidative stress: cytoprotective enzymes, antioxidants, aging, role of the immune system
  • 13. Brain iron metabolism, the role of iron in neurodegenerative diseases
  • 14. Pathophysiology of Iron overload: hemochromatosis

Reading material

Obligatory literature

Literature developed by the Department

The educational materials will be uploaded to Neptune MeetStreet

Notes

Recommended literature

Robert Crichton: Iron Metabolism: From Molecular Mechanisms to Clinical Consequences

Conditions for acceptance of the semester

Max. 3 absences

Mid-term exams

Three tests with one possible retake.

Making up for missed classes

Personal consultation

Exam topics/questions

Simple choice test based on the seminars.

Examiners

Instructor / tutor of practices and seminars

  • Dr. Pandur Edina
  • Jánosa Gergely
  • Pap Ramóna
Rólunk