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Optogenetics - The World of Proteins Controlled by Light

Data

Official data in SubjectManager for the following academic year: 2024-2025

Course director

Number of hours/semester

lectures: 0 hours

practices: 0 hours

seminars: 12 hours

total of: 12 hours

Subject data

  • Code of subject: OAF-OPG-T
  • 1 kredit
  • General Medicine
  • Optional modul
  • spring
Prerequisites:

OAA-BI1-T finished , OAA-MB1-T finished

Course headcount limitations

min. 5 – max. 24

Topic

Optogenetics refers to the intracellular use of photosensitive proteins that can be turned on or off using light to finely regulate specific biochemical processes.

This dynamically evolving revolutionary research method was first used by neuroscience in the early 2000s, but today, conquering several other fields of natural sciences, it can be found in basic biological, biophysical and biotechnological research as well as in many areas of medicine.

In order to demonstrate the extensive use of these proteins, we review the most well-known types of light-sensitive proteins, their mechanisms of action, and their biophysical characteristics. We then show, through a wealth of practical examples, how these proteins can be utilised. In addition to the methods used in basic research, we also focus on practical applications in medicine, primarily by presenting the latest advances in the treatment of certain diseases.

Lectures

Practices

Seminars

  • 12. Test - Fekete Zsuzsanna
  • 11. Optogenetic applications in research and medicine III. - Pécsi Ildikó
  • 10. Optogenetic applications in research and medicine II. - Telek Elek
  • 9.

    Optogenetic applications in research and medicine I.

    - Fekete Zsuzsanna
  • 8. Photophysics of flavoproteins II. - Lukács András Szilárd
  • 7. Photophysics of flavoproteins I. - Lukács András Szilárd
  • 6. Optopharmacology - Pasitka Jonatán
  • 5. Non-opsin-based photoreceptors III. - Fekete Zsuzsanna
  • 4. Non-opsin-based photoreceptors II. - Fekete Zsuzsanna
  • 2. Opsins - Fekete Zsuzsanna
  • 3. Non-opsin-based photoreceptors I. - Fekete Zsuzsanna
  • 1. Introduction, historical overview - Fekete Zsuzsanna

Reading material

Obligatory literature

Literature developed by the Department

Will be published on Teams, Moodle or PotePedia.

Notes

Recommended literature

Conditions for acceptance of the semester

None

Mid-term exams

Will be published on Teams, Moodle or PotePedia.

Making up for missed classes

None

Exam topics/questions

Will be published on Teams, Moodle or PotePedia.

Examiners

Instructor / tutor of practices and seminars

  • Fekete Zsuzsanna
  • Lukács András Szilárd
  • Pasitka Jonatán
  • Pécsi Ildikó
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