Pharmaceutical Biochemistry 1

Data

Official data in SubjectManager for the following academic year: 2020-2021

Topic

The two-semester biochemistry course provides the essential fundamental biochemistry knowledge for the pharmaceutical students. This course deals with the metabolic pathways of the living cell: the reactions, steps and regulation of these pathways. In the first semester students will be introduced to the life of the basic synthetic and anabolic biochemical pathways and they will study how energy is produced in the cell. We will pay special attention to enzymes: their features, regulations, roles in the drug metabolism and action.

Lectures

• 1. Introduction - Dr. Sipos Katalin
• 2. Thermodynamics, biochemical reactions - Dr. Sipos Katalin
• 3. Biomembranes. Transport processes I - Dr. Sipos Katalin
• 4. Transport processes II - Dr. Sipos Katalin
• 5. Enzymes: characteristics, types, catalytic activities - Dr. Sipos Katalin
• 6. Channels, action potential - Dr. Sipos Katalin
• 7. Basic regulatory mechanisms in metabolism - Dr. Sipos Katalin
• 8. Glycolysis - Dr. Sipos Katalin
• 9. Gluconeogenesis - Dr. Farkas Viktória
• 10. Glycogen metabolism - Dr. Farkas Viktória
• 11. Cori cycle - Dr. Farkas Viktória
• 12. Pentose phosphate pathway - Dr. Farkas Viktória
• 13. Metabolism of complex carbohydrates - Dr. Sipos Katalin
• 14. Pyruvate dehydrogenase complex - Dr. Farkas Viktória
• 15. Citric acid cycle - Dr. Sipos Katalin
• 16. Mitochondrial transport processes - Dr. Farkas Viktória
• 17. Terminal oxidation, ATP synthesis I - Dr. Farkas Viktória
• 18. Terminal oxidation, ATP synthesis II - Dr. Farkas Viktória
• 19. Degradation of lipids - Dr. Sipos Katalin
• 20. Ketone bodies - Dr. Farkas Viktória
• 21. Biosynthesis of fatty acids - Dr. Farkas Viktória
• 22. Biosynthesis of complex lipids - Dr. Sipos Katalin
• 23. Cholesterol metabolism I - Dr. Farkas Viktória
• 24. Cholesterol metabolism II - Dr. Farkas Viktória
• 25. Characterization of amino acids - Pap Ramóna
• 26. Nucleic acids: building blocks, structures - Pap Ramóna
• 27. Preparation for exam - Dr. Sipos Katalin
• 28. Preparation for exam - Dr. Sipos Katalin

Practices

Seminars

• 1. Macromolecules in biochemistry
• 2. Nutrition and vitamins in biochemistry
• 3. Carbohydrates: biochemical characterization. Carbohydrates in the extracellular space
• 4. Clinical importance of carbohydrates
• 5. Regulation of enzymes
• 6. Enzymekinetics. Inhibition of enzymes
• 7. Structure, folding and degradation of proteins
• 8. Lipids: phospholipids, sphingolipids, cholesterol, fatty acids
• 9. Clinical importance of lipids
• 10. Clinical consequences of terminal oxidation.
• 11. Carbohydrate metabolism
• 12. Lipid metabolism
• 13. Enzyme inhibiting drugs
• 14. Preparation for exam

Reading material

Obligatory literature

Literature developed by the Department

The materials of the lectures and seminars will appear on Neptune.

Notes

The e-notes of Biochemistry will appear on Neptune.

Recommended literature

Ch. P. Woodbury: Biochemistry for the Pharmaceutical Sciences
Raymond S. Ochs: Biochemistry
Thomas M. Devlin: Textbook of Biochemistry with Clinical Correlations

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

There is no written mid-term exam.

Making up for missed classes

According to personal agreement

Exam topics/questions

There are no given exam questions. The topics of the exam will be the materials of lectures and seminars.

Examiners

• Dr. Farkas Viktória
• Dr. Sipos Katalin

Instructor / tutor of practices and seminars

• Dr. Farkas Viktória
• Dr. Pandur Edina
• Dr. Sipos Katalin