Supervisor: PÁRNICZKY, Andrea
Co-supervisor: Dr. SZAKÁCS, Zsolt
Cystic fibrosis (CF) is caused by a loss of function mutation in the CFTR chloride channel (most commonly deltaF508), which causes abnormalities in the function of the external glands. It is a complex disorder that is mainly associated with severe respiratory and digestive symptoms and usually affects the pancreas as well. Pancreatic parenchymal damage may occur early in life, even in utero, leading to the development of cystic fibrosis-related diabetes (CFRD). The disease, in addition to other rare causes of diabetes, is classified as type 3 diabetes mellitus.
In this topic, we will perform a meta-analysis to investigate methods used to diagnose CFRD. The purpose of the diagnostic test accuracy meta-analysis is to compare different modalities to each other, thereby ranking them. According to current guidelines, the gold standard diagnostic test is the oral glucose tolerance test (OGTT), but several other modalities are available (e.g., continuous glucose monitoring, fasting blood glucose levels and haemoglobin A1C). Our results can contribute to the selection of the best (and most cost-effective) diagnostic option.
Supervisor: PÁRNICZKY, Andrea
Co-supervisor: Prof. Dr. MOLNÁR, Lajos Zsolt
The severe form of acute pancreatitis is similar in the aspect of pathophysiology and course of disease to septic shock. Both clinical conditions are associated with high mortality. Since the incidence of the severe cases of acute pancreatitis is rare (about 10% of all acute pancreatitis cases), there is only limited information about the course of disease, diagnostics and therapy. The aim of our study group is to establish an extensive research program to study patients who require intensive or subintensive care. In addition to retrospective, prospective and observational studies we are also planning prospective randomized controlled trials. One of our main goals is to expand our knowledge on extracorporal cytokine adsorption therapy, therefore we are initiating multicenter clinical trials on the cytokine adsorption therapy in patients with septic shock and with severe acute pancreatitis.
Supervisor: SZAKÁCS, Zsolt
Co-supervisor: Dr. PÁRNICZKY, Andrea
Cystic fibrosis (CF) is caused by a loss of function mutation in the CFTR chloride channel (most commonly deltaF508), which causes abnormalities in the function of the external glands. It is a complex disorder that is mainly associated with severe respiratory and digestive symptoms. In CF patients, the lungs become more susceptible to bacterial infections and may sustain chronic lung injury, leading to respiratory failure and even to death.
In the study, we use the Hungarian CF Registry to investigate the relationship between the clinical picture and microbiological profile of CF-associated lung injury. The aim of the research is to evaluate the microbiological and clinical features of the Hungarian CF population with statistical analysis. Results can contribute to the improvement of patient’s quality of life and medical attendance.