Pharmaceutical Technology 1

Data

Official data in SubjectManager for the following academic year: 2024-2025

Topic

Courses of pharmaceutical technology are taught in the 3rd and 4th years of school of pharmacy. Aim of courses of Pharmaceutical Technology is introducing basic technological processes, preformulation and formulation of pharmaceutical dosage forms taking into account physico-chemical, pharmaceutical and biopharmaceutical properties of active agents and pharmaceutical excipients.

Further studies include review of national and international pharmacopoeias.

Practices usually begin with seminars where basic introduction of the proper lesson takes place. After seminars students have to prepare medicines according to the laws of pharmaceutical formulation technology in proper dosage forms including calculation of single and daily maximal dose, preparation, labeling and pricing. Students also have to prepare galenic formulations according to the official formula. Practices of quality control of medicines are carried out as well.

Course Pharmaceutical Technology 1 includes practice with liquid dosage forms such as solution, syrup, elixir, oral drop, ear drop, nasal drop, parenteral solution and associated calculations with practices of quality control of mentioned dosage forms.

Lectures

• 1. Defination of medication and dosage form. History of preparation of medications. The subjects and tasks of pharmaceutical technology, basic terms. - Pál Szilárd
• 2. Defination of medication and dosage form. History of preparation of medications. The subjects and tasks of pharmaceutical technology, basic terms. - Pál Szilárd
• 3. Dispensing and compounding at a pharmacy (measurement, treatment of substances) - Pál Szilárd
• 4. Dispensing and compounding at a pharmacy (measurement, treatment of substances) - Pál Szilárd
• 5. Basics of technological operations, biopharmaceutical aspects - Pál Szilárd
• 6. Basics of technological operations, biopharmaceutical aspects - Pál Szilárd
• 7. Technological importance of substances - Pál Szilárd
• 8. Technological importance of substances - Pál Szilárd
• 9. Dissolution - Pál Szilárd
• 10. Written test - Pál Szilárd
• 11. Excipients used to increase of API's solubility - Pál Szilárd
• 12. Excipients used to increase of API's solubility - Pál Szilárd
• 13. Mixing and stirring - Pál Szilárd
• 14. Mixing and stirring - Pál Szilárd
• 15. Heat transferes - Secenji Aleksandar
• 16. Heat transferes - Secenji Aleksandar
• 17. Interaction and incompatibility of pharmaceutical preparations - Pál Szilárd
• 18. Interaction and incompatibility of pharmaceutical preparations - Pál Szilárd
• 19. Written test - Pál Szilárd
• 20. Written test - Pál Szilárd
• 21. Sterilization, depyrogenation, aseptic working, eye preparations - Kása Péter
• 22. Sterilization, depyrogenation, aseptic working, eye preparations - Kása Péter
• 23. Preparation and examination of injection (API, excipients, solvents, containers, examination) - Pál Szilárd
• 24. Preparation and examination of injection (API, excipients, solvents, containers, examination) - Pál Szilárd
• 25. Infusions and implants. The most important class of injectable and plantable preparations - Pál Szilárd
• 26. Infusions and implants. The most important class of injectable and plantable preparations - Pál Szilárd
• 27. Written test - Pál Szilárd
• 28. Written test - Pál Szilárd

Practices

• 1. General instructions, rules and regulations on practices, measuring, scales, introduction to reading prescriptions
• ...

  2. General instructions, rules and regulations on practices, measuring, scales, introduction to reading prescriptions

  3. General instructions, rules and regulations on practices, measuring, scales, introduction to reading prescriptions

  4. General instructions, rules and regulations on practices, measuring, scales, introduction to reading prescriptions
• 5. General instructions, rules and regulations on practices, measuring, scales, introduction to reading prescriptions
• 6. Preparation of pure solutions, physical examination of solutions, diluting alcohol, pharmaceutical calculations
• ...

  7. Preparation of pure solutions, physical examination of solutions, diluting alcohol, pharmaceutical calculations

  8. Preparation of pure solutions, physical examination of solutions, diluting alcohol, pharmaceutical calculations

  9. Preparation of pure solutions, physical examination of solutions, diluting alcohol, pharmaceutical calculations
• 10. Preparation of pure solutions, physical examination of solutions, diluting alcohol, pharmaceutical calculations
• 11. Complex solutions, mixtures, drops
• ...

  12. Complex solutions, mixtures, drops

  13. Complex solutions, mixtures, drops

  14. Complex solutions, mixtures, drops
• 15. Complex solutions, mixtures, drops
• 16. Colloid solutions, examination of pure and colloid solutions, nasal drops and ear drops
• ...

  17. Colloid solutions, examination of pure and colloid solutions, nasal drops and ear drops

  18. Colloid solutions, examination of pure and colloid solutions, nasal drops and ear drops

  19. Colloid solutions, examination of pure and colloid solutions, nasal drops and ear drops
• 20. Colloid solutions, examination of pure and colloid solutions, nasal drops and ear drops
• 21. Preparation and examination of pure solutions, alcoholic solutions
• ...

  22. Preparation and examination of pure solutions, alcoholic solutions

  23. Preparation and examination of pure solutions, alcoholic solutions

  24. Preparation and examination of pure solutions, alcoholic solutions
• 25. Preparation and examination of pure solutions, alcoholic solutions
• 26. Preparation and examination of syrups and colloid solutions
• ...

  27. Preparation and examination of syrups and colloid solutions

  28. Preparation and examination of syrups and colloid solutions

  29. Preparation and examination of syrups and colloid solutions
• 30. Preparation and examination of syrups and colloid solutions
• 31. Preparation and examination of mucilages and colloid solutions
• ...

  32. Preparation and examination of mucilages and colloid solutions

  33. Preparation and examination of mucilages and colloid solutions

  34. Preparation and examination of mucilages and colloid solutions
• 35. Preparation and examination of mucilages and colloid solutions
• 36. Assessment
• ...

  37. Assessment

  38. Assessment

  39. Assessment
• 40. Assessment
• 41. Sterilizing, isotonisation, calculations, eye drops
• ...

  42. Sterilizing, isotonisation, calculations, eye drops

  43. Sterilizing, isotonisation, calculations, eye drops

  44. Sterilizing, isotonisation, calculations, eye drops
• 45. Sterilizing, isotonisation, calculations, eye drops
• 46. Preparation of eye drops, ointments
• ...

  47. Preparation of eye drops, ointments

  48. Preparation of eye drops, ointments

  49. Preparation of eye drops, ointments
• 50. Preparation of eye drops, ointments
• 51. Preparation and examination of injections
• ...

  52. Preparation and examination of injections

  53. Preparation and examination of injections

  54. Preparation and examination of injections
• 55. Preparation and examination of injections
• 56. Preparation and examination of infusions
• ...

  57. Preparation and examination of infusions

  58. Preparation and examination of infusions

  59. Preparation and examination of infusions
• 60. Preparation and examination of infusions
• 61. Preparation and examination of emulsions and suspensions
• ...

  62. Preparation and examination of emulsions and suspensions

  63. Preparation and examination of emulsions and suspensions

  64. Preparation and examination of emulsions and suspensions
• 65. Preparation and examination of emulsions and suspensions
• 66. End semester assessment
• ...

  67. End semester assessment

  68. End semester assessment

  69. End semester assessment
• 70. End semester assessment

Seminars

Reading material

Obligatory literature

Literature developed by the Department

Notes

Recommended literature

International Pharmacopoeias

European Pharmacopoeia

Hungarian National Formulary: Formulae Normales VII (FoNo VII.)

James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, New York, London

Susanna Wu-Pong, Yon Rojanasakul: Biopharmaceutical Drug Design and Development, Humana Press

Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel

European Pharmacopoeia

Formulae Normales VII. (FoNo VII.)

James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, New York, London

Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel

Chris Langley, Dawn Belcher: Pharmaceutical Compounding and Dispensing, Pharmaceutical Press

www.gytk.pte.hu

www.sciencedirect.com

Attila Dévay: The Theory and Practice of Pharmaceutical Technology, electronic book, PTE-Pécs

Attila Dévay: Investigation of Pharmaceutical Preparations, electronic book, PTE-Pécs

Conditions for acceptance of the semester

1. Accepted preparations made on practices.

2. Accepted work reports.

3. Accepted practical and theoretical assessments.

4. At the beginning of all practice classes students write short tests of different types (dose checking, synonim names and latin expressions, calculations). Semester only can be accepted if students reach at least 50% from each short test type.

Evaluation of the practices is according to the semester work (practice work, assessments, work reports) by practice grade. In case of fulfilled 1-3 sections, the requirement of the accepted semester is to reach at least satisfactory grade.

Mid-term exams

Students have to write three assessments during the semester and they have to reach 60 % after average calculation. After two assessments if students reach average 60 % taking into account both tests, writing the third assesment it not compulsory. The third assessments (which is considered as the 1st retake) has to above 60,1 %. If the student fails on the 3rd assessment, there is still chance for the 2nd retake, where student has to reach 60,1% for the acceptance of the semester. In case of confirmed absence from the assessment, re-take chance is sossible for the student. Missing the re-take results 0 % assessment.

Making up for missed classes

Students must fulfil requirements determined by the Code of Studies and Examinations.

All missed or failed preparations manufactured on the practice should be made up on supplementary practices!

Exam topics/questions

The end-semester exam will be evaluated by a five-grade system. Knowledge acquired is tested based on subject matter defined by a list of topics provided by the institute.

At the end of semester, students take oral exam. The "A" chance exam is in determined date for students finishing the course. Chance "B" and "C" are oral exams, which is preceded by the "Minimum Test" (MT). To write the MT, students have at most 30 minutes, and will be evaluated percent rating. Those students, who achieve less than 60% in MT, unsatisfactory grade will be assessed and cannot pass them to the oral part of the exam.

Oral part includes two topics. In the case of any part done with insufficient knowledge, will result in assessment of the exam to unsatisfactory grade.

Examiners

• Ámanné Takácsi-Nagy Anna Erzsébet
• Kása Péter
• Mayer Klára
• Pál Szilárd

Instructor / tutor of practices and seminars

• Kása Péter
• Pál Szilárd
• Secenji Aleksandar