Pharmaceutical Biology 2

Data

Official data in SubjectManager for the following academic year: 2024-2025

Topic

The 2-semester Biology course provides the essential fundamental molecular biological knowledge for the pharmaceutical students. In the second semester some of the lectures are about the regulation of cell cycle and molecular biology of cancer. The main part of the second semester deals with the essential information on pharmaceutical genetics. This knowledge is important for pharmaceutical students to understand the mechanisms of actions of drugs and research on drug discovery and development.

Lectures

• 1. Cell signalling pathways - Pandur Edina
• 2. Intracellular signalling molecules - Pandur Edina
• 3. Membrane receptor molecules - Pandur Edina
• 4. Ca, cGMP - Pandur Edina
• 5. Apoptosis I. - Pap Ramóna
• 6. Apoptosis II. - Pap Ramóna
• 7. Molecular biology of cancer I. - Pandur Edina
• 8. Molecular biology of cancer II. - Pandur Edina
• 9. Ras - Pandur Edina
• 10. PI-3 kinase, Jak-STAT - Pandur Edina
• 11. Basis terms of medical genetics. - Pap Ramóna
• 12. Chromosomal disorders - Pap Ramóna
• 13. Chromosomal disorders: in number and structure - Jánosa Gergely
• 14.

  Transcription

  - Jánosa Gergely
• 15.

  Autosomal genetic disorders.

  - Pap Ramóna
• 16.

  Sex chromosome aberrations.

  - Pap Ramóna
• 17. Mendelian inheritance I. - Jánosa Gergely
• 18. DNA, cell cycle - Jánosa Gergely
• 19. Signal transduction and drugs - Pandur Edina
• 20. Mitochondrial genetic disorders. - Poór Viktor Soma
• 21. Multifactorial disorders. - Pap Ramóna
• 22.

  Proteins - summary

  - Jánosa Gergely
• 23.

  DNA, cell cycle

  - Jánosa Gergely
• 24. Translation - Pandur Edina
• 25. Inborn genetic errors. - Pap Ramóna
• 26. Possibilities of treatments of genetic defects. - Poór Viktor Soma
• 27. DNA repair mecahnisms - Poór Viktor Soma
• 28.

  Preparation for exam.

  - Pap Ramóna

Practices

• 1. Western blotting.
• 2. Cell culture techniques.
• 3. DNA isolation
• 4. Determination of DNA concentration, running DNA on agarose gel
• 5. RNA isolation
• 6. Concentration of RNA, synthesis of cDNA
• 7. DNA digestion with restriction enzymes
• 8. Running digested DNA sample on agarose gel
• 9.

  PCR I

• 10.

  PCR II

Seminars

• 1. Viruses, prions
• 2. Cell signaling: summary
• 3. Apoptosis: summary
• 4. Real time PCR: demonstration
• 5. Cell culture techniques
• 6. Familial inheritance
• 7. Epigenetics
• 8. Genetic screening
• 9. Pharmacogenetics, pharmacogenomics I
• 10. Pharmacogenetics, pharmacogenomics II
• 11. Genetic diseases in the adulthood
• 12. Inherited genetic diseases (Mendelian)
• 13. Other genetic diseases
• 14. Cytogenetics
• 15. Pharmaceutical research I
• 16. Pharmaceutical research II
• 17.

  Technical summary

• 18. Consultation

Reading material

Obligatory literature

Literature developed by the Department

The materials of the lectures and seminars will appear on Neptune.

Notes

Electronic note on Pharmaceutical Biology can be found on Neptun Meet Street.

Recommended literature

Cooper GM: The Cell: A Molecular Approach, 2nd edition, PubMed

Elliott WH, Elliott DC: Biochemistry and Molecular Biology, 3rd edition

Thompson & Thompson: Genetics in Medicine

Craig NL: Molecular Biology, Principles of Genome Function, OUP 2010

Young ID: Medical Genetics

Conditions for acceptance of the semester

No other terms for acceptance.

Mid-term exams

There is no written mid-term exam in the semester.

Making up for missed classes

According to personal agreement

Exam topics/questions

There are no given exam questions. The topics of the exam will be the materials of lectures and seminars.

Examiners

• Jánosa Gergely
• Pandur Edina
• Pap Ramóna
• Sipos Katalin

Instructor / tutor of practices and seminars

• Jánosa Gergely
• Pandur Edina
• Pap Ramóna
• Sipos Katalin
• Tamási Kitti