Medical Biochemistry

Data

Official data in SubjectManager for the following academic year: 2020-2021

Topic

The final exam in "Medical Biochemistry" covers the material of subjects of four semesters (Medical Chemistry, Introduction to Biochemistry, Biochemistry, Medical Biochemistry). The material of the four semesters present the metabolic processes and the molecular events of biological information transmission with special respect to the properties and functions of the participating biomolecules. Thus, students are supposed to gain a molecular level insight into the processes by which living organisms sustain their life functions or react to various stimuli, physiological or pathological conditions.
Within these four semesters the subject "Medical Biochemistry", based on previously acquired knowledge, presents the molecular level alterations appearing under various physiological and pathological circumstances with special respect to organ and organelle specific issues. Moreover, the biochemical background of related disorders and diseases will be also mentioned.
The material of the final exam is direct prerequisite of higher year subjects Pharmacology, Pathophysiology, Microbiology and Clinical Biochemistry. In addition, the material covers the introduction to certain chapters of Internal Medicine and Paediatrics also.

Lectures

• 1. Introduction - Dr. Berente Zoltán
• 2. Interorgan division of metabolic labour - Dr. Berente Zoltán
• 3. Nutrition 1: Macro- and micronutrients, caloric balance - Dr. Berente Zoltán
• 4. Nutrition 2: digestion fluids and digestion enzymes - Dr. Berente Zoltán
• 5. Metabolic changes when switching from fed to fasting state - Dr. Gallyas Ferenc
• 6. Serum lipoproteins - Dr. Berente Zoltán
• 7. Special functions of the liver - Dr. Veres Balázs
• 8. Molecular events following alcohol ingestion - Dr. Kovács Krisztina
• 9. Trace elements, deficiencies - Dr. Berente Zoltán
• 10. Iron metabolism - Dr. Kovács Krisztina
• 11. Structural variants of hemoglobin - Dr. Kovács Krisztina
• 12. Proteins in blood, blood clotting, biochemistry of the blood vessels - Dr. Kovács Krisztina
• 13. Molecular mechanisms of water and electrolyte household - Dr. Berente Zoltán
• 14. Molecular mechanisms of blood pressure regulation - Dr. Jávor-Hocsák Enikő
• 15. Molecular mechanisms of cardiac function - Dr. Bognár Zita
• 16. Biochemistry of the senses - Dr. Tapodi Antal
• 17. Nervous system I - Dr. Tapodi Antal
• 18. Nervous system II - Dr. Gallyas Ferenc
• 19. Nervous system III - Dr. Gallyas Ferenc
• 20. Biochemical background of the pH regulation - Dr. Berente Zoltán
• 21. Biochemical background of diabetes - Nagyné Dr. Kiss Gyöngyi
• 22. Molecular mechanisms of glucose uptake - Nagyné Dr. Kiss Gyöngyi
• 23. Oxidative stress induced signalling pathways - Dr. Jávor-Hocsák Enikő
• 24. Biochemistry of the inflammatory processes - Dr. Veres Balázs
• 25. Molecular mechanisms of the synovial function - Dr. Kovács Krisztina
• 26. Mechanisms of cell death - Dr. Veres Balázs
• 27. The cell cycle and its regulation - Dr. Balogi Zsolt
• 28. Oncogenes and oncogenesis - Dr. Balogi Zsolt
• 29. Tumor suppressors and cancer - Dr. Bognár Zita
• 30. Structure of the extracellular matrix - Dr. Tapodi Antal
• 31. Matrix metalloproteinases - Dr. Gallyas Ferenc
• 32. Biochemical features of the plasma membrane - Nagyné Dr. Kiss Gyöngyi
• 33. Biochemistry of the cytoskeletal function - Dr. Gallyas Ferenc
• 34. Molecular features of ER and Golgi - Dr. Gallyas Ferenc
• 35. Biochemical functions of lysosomes and peroxisomes - Dr. Tapodi Antal
• 36. Molecular mechanisms of the mitochondrial function - Dr. Veres Balázs
• 37. Proteins and biochemistry of the immune system - Dr. Kovács Krisztina
• 38. Molecular mechanisms of allergic reactions - Dr. Kovács Krisztina
• 39. Biochemistry of senescence - Dr. Gallyas Ferenc
• 40. Cellular regeneration - Marquettené Dr. Bock Ildikó
• 41. Progenitor cells - Marquettené Dr. Bock Ildikó
• 42. Therapeutics of the future - Marquettené Dr. Bock Ildikó

Practices

• 1. Distribution of enzymes among tissues
• 2. Distribution of enzymes among tissues
• 3. Molecular biological methods
• 4. Molecular biological methods
• 5. Analysis of body fluids
• 6. Analysis of body fluids
• 7. Hormonal Regulation of Metabolism
• 8. Hormonal Regulation of Metabolism
• 9. Determination of blood glucose
• 10. Determination of blood glucose
• 11. Organspecific Biochemistry
• 12. Organspecific Biochemistry
• 13. Student presentations
• 14. Student presentations
• 15. Student presentations
• 16. Student presentations
• 17. Determination of blood cholesterol
• 18. Determination of blood cholesterol
• 19. Stress Responses in Metabolism
• 20. Stress Responses in Metabolism
• 21. Determination of uric acid and bilirubin from blood
• 22. Determination of uric acid and bilirubin from blood
• 23. Acquired disorders of metabolism
• 24. Acquired disorders of metabolism
• 25. Study of cholinesterase
• 26. Study of cholinesterase
• 27. Consultation
• 28. Consultation

Seminars

Reading material

Obligatory literature

Nelson, Cox: Lehninger Principles of Biochemistry, 7th edition, W.H. Freeman, 2017.

Literature developed by the Department

http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Notes

http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Recommended literature

Berg, Tymoczko, Stryer: Biochemistry, 8th edition, W.H. Freeman, 2015.
Devlin: Textbook of Biochemistry with Clinical Correlations, 7th edition, Wiley, 2010.
Lieberman, Marks: Marks' Basic Medical Biochemistry - A Clinical Approach, 4th edition, Lippincott, 2013

Conditions for acceptance of the semester

No more than three absences from the laboratory practices
No more than two absences from the laboratory practices during weeks 3-14.
At least seven of the twelve laboratory practices of weeks 3-14 must be successfully accomplished (i.e. a successful test must be submitted at the beginning and a filled notebook must be presented at the end of the lab).

Mid-term exams

At the beginning of each practice a short test (with one single question) must be written. Each test can be worth of 1 or 0 exam points.

Making up for missed classes

None.

Exam topics/questions

Exam requirements can be found:
http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Further exam points can be achieved by oral presentations or extra work during the semester.

Examiners

• Dr. Berente Zoltán
• Dr. Gallyas Ferenc

Instructor / tutor of practices and seminars

• Dr. Fekete Katalin
• Dr. Jakus Péter Balázs
• Dr. Jávor-Hocsák Enikő
• Dr. Takátsy Anikó
• Dr. Tapodi Antal
• Dr. Veres Balázs
• Kőszegi Balázs
• Nagyné Dr. Kiss Gyöngyi