Biochemistry

Data

Official data in SubjectManager for the following academic year: 2024-2025

Topic

The subject gives an overview of the molecular processes occurring in living organisms from two major aspects.

On the one hand, following the subject Introduction to Biochemistry, describes the metabolism of the four major types of biomolecules (carbohydrates, lipids, amino acids/proteins and nucleotides/nucleic acids) along with the indirect enzymatic regulation of these processes.

On the other hand, built on the subjects Introduction to Biochemistry and Molecular Cell Biology, accounts for the molecular processes responsible for the transmission of information within the living organisms from molecular biological (DNA-RNA-protein-metabolite) as well as hormonal point of view.

The subject lies down the foundations of the subjects Medical Biochemistry, Pharmacology and Clinical Chemistry.

Lectures

• 1. Introduction - Veres Balázs
• 2. Biochemical processes (overview) - Veres Balázs
• 3.

  Reactions of glycolysis

  - Veres Balázs
• 4.

  Regulation of glycolysis

  - Veres Balázs
• 5.

  Metabolic pathways linked to glycolysis

  - Veres Balázs
• 6.

  Pentose phosphate pathway

  - Veres Balázs
• 7.

  Reactions of TCA cycle (PDC included)

  - Veres Balázs
• 8.

  Regulation of TCA cycle

  - Veres Balázs
• 9.

  Fatty acid oxidation

  - Jávor-Hocsák Enikő
• 10.

  Ketonbodies

  - Jávor-Hocsák Enikő
• 11. Respiratory chain and its inhibition - Takátsy Anikó
• 12. ATP synthesis - Takátsy Anikó
• 13. Mitochondrial transport processes, shuttles - Takátsy Anikó
• 14.

  Gluconeogenesis

  - Berente Zoltán
• 15.

  Glycogen synthesis and degradation

  - Kovács Krisztina (Biokémia)
• 16.

  Regulation of glycogen metabolism

  - Kovács Krisztina (Biokémia)
• 17.

  Regulation of carbohydrate metabolism

  - Gallyas Ferenc
• 18.

  Fatty acid synthesis

  - Balogi Zsolt
• 19.

  Synthesis of complex lipids

  - Balogi Zsolt
• 20.

  Cholesterol and lipoproteins

  - Tapodi Antal
• 21.

  Regulation of lipid metabolism

  - Tapodi Antal
• 22.

  Amino acid metabolism: the fate of amino group

  - Kovács Krisztina (Biokémia)
• 23.

  Urea cycle

  - Kovács Krisztina (Biokémia)
• 24.

  Amino acid metabolism: the fate of carbon skeleton

  - Kovács Krisztina (Biokémia)
• 25.

  Synthesis of non-essential amino acids

  - Kovács Krisztina (Biokémia)
• 26.

  Enzymopathies in amino acid metabolism

  - Kovács Krisztina (Biokémia)
• 27.

  Biologically active compounds

  - Gallyas Ferenc
• 28.

  Synthesis of purin and pyrimidin nucleotides

  - Berente Zoltán
• 29.

  Degradation of purin and pyrimidin nucleotides

  - Berente Zoltán
• 30.

  Protein -DNA interactions

  - Berente Zoltán
• 31.

  Regulation of gene expression

  - Nagyné Kiss Gyöngyi
• 32.

  Small RNAs

  - Nagyné Kiss Gyöngyi
• 33.

  Retroviruses

  - Nagyné Kiss Gyöngyi
• 34.

  Folding, PTM

  - Tapodi Antal
• 35.

  Protein targeting, degradation

  - Tapodi Antal
• 36.

  Hormones 1

  - Marquettené Bock Ildikó
• 37.

  Hormones 2

  - Marquettené Bock Ildikó
• 38. Signal transduction I. - Gallyas Ferenc
• 39. Signal transduction II. - Gallyas Ferenc
• 40. Signal transduction III. - Gallyas Ferenc
• 41.

  Water soluble vitamins

  - Jávor-Hocsák Enikő
• 42. Fat soluble vitamins - Jávor-Hocsák Enikő

Practices

• 1. Introductory lab
• 2. Introductory lab
• 3. Biochemical methods
• 4. Biochemical methods
• 5. Inorganic phosphate requirement of glycolysis
• 6. Inorganic phosphate requirement of glycolysis
• 7. Concerted regulation of carbohydrate metabolism I.
• 8. Concerted regulation of carbohydrate metabolism I.
• 9. Concerted regulation of lipid metabolism I.
• 10. Concerted regulation of lipid metabolism I.
• 11. OXPHOS
• 12. OXPHOS
• 13. Concerted regulation of carbohydrate metabolism II.
• 14. Concerted regulation of carbohydrate metabolism II.
• 15. Concerted regulation of lipid metabolism II.
• 16. Concerted regulation of lipid metabolism II.
• 17. N-containing mol. Metabolism
• 18. N-containing mol. Metabolism
• 19. Inborn Errors of Metabolism
• 20. Inborn Errors of Metabolism
• 21. Escape room
• 22. Escape room
• 23. Student presentations I.
• 24. Student presentations I.
• 25. Student presentations II.
• 26. Student presentations II.
• 27. Consultation
• 28. Consultation

Seminars

Reading material

Obligatory literature

Nelson, Cox: Lehninger Principles of Biochemistry, 6th edition, W.H. Freeman, 2013.

Literature developed by the Department

http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Notes

http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Recommended literature

Berg, Tymoczko, Stryer: Biochemistry, 7th edition, W.H. Freeman, 2012.

Devlin: Textbook of Biochemistry with Clinical Correlations, 7th edition, Wiley, 2010.

Conditions for acceptance of the semester

Requirements of the acceptance of Biochemistry course are the following:

- No more than three absences from the laboratory practices

- Submission of at least 10 out of 12 short tests held in the first 10 minutes of the practices

- Achieving satisfactory level in at least seven of the 12 short tests

Mid-term exams

http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Making up for missed classes

There is no possibility to make up the practices.

Exam topics/questions

http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Examiners

• Agócs Attila
• Andreidesz Kitti
• Antus Csenge Petra
• Bagóné Vántus Viola
• Berente Zoltán
• Bognár Zita
• Fekete Katalin
• Jakus Péter Balázs
• Jávor-Hocsák Enikő
• Kálmán Nikoletta
• Kőszegi Balázs
• Kovács Dominika
• Kovács Krisztina (Biokémia)
• Nagyné Kiss Gyöngyi
• Radnai Balázs (Biokémia)
• Szabó Aliz
• Takátsy Anikó
• Tapodi Antal
• Veres Balázs

Instructor / tutor of practices and seminars

• Agócs Attila
• Andreidesz Kitti
• Antus Csenge Petra
• Bagóné Vántus Viola
• Berente Zoltán
• Bognár Zita
• Fekete Katalin
• Jávor-Hocsák Enikő
• Kálmán Nikoletta
• Kőszegi Balázs
• Kovács Dominika
• Kovács Krisztina (Biokémia)
• Nagyné Kiss Gyöngyi
• Radnai Balázs (Biokémia)
• Takátsy Anikó
• Tapodi Antal
• Veres Balázs