Medical Biochemistry

Data

Official data in SubjectManager for the following academic year: 2024-2025

Topic

The Medical Biochemistry course is a semester course, ending with an oral exam. Knowledge of the metabolic processes learned in the Biochemistry subject is necessary for the Medical Biochemistry subject, although the Biochemistry final exam is not a prerequisite for taking the subject. The course aims to provide insight into how the living organism (at the molecular level) performs its physiological functions or reacts to various environmental stimuli, physiological and pathological conditions. During the semester, we present the organ- and organelle-specific aspects of metabolism, as well as discuss the biochemical background of related disorders/diseases.

Lectures

• 1. Introduction / Division of metabolic tasks between the organs - Gallyas Ferenc
• 2. Metabolic diseases of the carbohydrates - Berente Zoltán
• 3. Lipid and nucleotide metabolic diseases - Gallyas Ferenc
• 4. Disorders of amino acid metabolism - Veres Balázs
• 5. Nutrition: macro- and micronutrients - Szabó Éva (Biokémia)
• 6. Trace elements, deficiency diseases - Szabó Éva (Biokémia)
• 7. Regulation of body weight, diets - Gallyas Ferenc
• 8. Sport, lifestyle - Berente Zoltán
• 9. Special functions of the liver, biotransformation processes - Veres Balázs
• 10. Biochemical consequences of alcohol consumption - Kovács Krisztina (Biokémia)
• 11. Iron metabolism in the human body - Kovács Krisztina (Biokémia)
• 12. Haemoglobinopathies, hyperbilirubinaemia - Veres Balázs
• 13. Biochemical principles of pH regulation - Berente Zoltán
• 14. Biochemistry of the pancreas - Takátsy Anikó
• 15. Molecular mechanisms of sugar absorption - Nagyné Kiss Gyöngyi
• 16. Biochemical background of diabetes mellitus - Nagyné Kiss Gyöngyi
• 17. The microbiome - Bagóné Vántus Viola
• 18. Diseases of the gastrointestinal tract - Kőszegi Balázs
• 19. Lipoproteins - Erős Krisztián
• 20. Biochemistry of the blood vessels - Bognár Zita
• 21. Biochemistry of kidney function - Takátsy Anikó
• 22. Molecular mechanisms of blood pressure regulation - Tapodi Antal
• 23. Molecular mechanisms of heart function - Marquettené Bock Ildikó
• 24. Bone and joint diseases - Rauch Tibor Attila
• 25. Oxidative stress induced signaling - Jávor-Hocsák Enikő
• 26. Biochemistry of inflammation - Rauch Tibor Attila
• 27. Nervous system I. - Gallyas Ferenc
• 28. Nervous system II. - Gallyas Ferenc
• 29. Nervous system III. - Gallyas Ferenc
• 30. Biochemistry of sensing - Jávor-Hocsák Enikő
• 31. Functions of the cytoskeleton - Berente Zoltán
• 32. Characteristics of the endoplasmic reticulum - Berente Zoltán
• 33. Functions of Golgi, lysosomes and peroxisomes - Tapodi Antal
• 34. Molecular mechanisms of mitochondrial function - Veres Balázs
• 35. Proteins and functions of the extracellular matrix - Nagyné Kiss Gyöngyi
• 36. Matrix metalloproteinases - Marquettené Bock Ildikó
• 37. Cell cycle and its regulation, therapeutic possibilities - Veres Balázs
• 38. Mechanisms of cell death - Veres Balázs
• 39. Tumour biochemistry - Balogi Zsolt
• 40. Biochemistry of senescence - Gallyas Ferenc
• 41. Metabolic pathways, metabolites in new roles - Antus Csenge Petra
• 42. Molecular background of personalized medicine - Gallyas Ferenc

Practices

• 1. Disorders of acid-base balance; pH measurement
• 2. Disorders of acid-base balance; pH measurement
• 3. Metabolic disorders
• 4. Metabolic disorders
• 5. Analysis of body fluids
• 6. Analysis of body fluids
• 7. Biochemistry of organs
• 8. Biochemistry of organs
• 9. Determination of blood glucose
• 10. Determination of blood glucose
• 11. Blood-liver-alcohol; (haemoglobin, iron, alcohol, biotransformation)
• 12. Blood-liver-alcohol; (haemoglobin, iron, alcohol, biotransformation)
• 13. Determination of blood cholesterol
• 14. Determination of blood cholesterol
• 15. Acquired metabolic diseases (obesity, diabetes mellitus, atherosclerosis)
• 16. Acquired metabolic diseases (obesity, diabetes mellitus, atherosclerosis)
• 17. Determination of uric acid
• 18. Determination of uric acid
• 19. Cellular stress response, ROS, inflammation
• 20. Cellular stress response, ROS, inflammation
• 21. Student presentations
• ...

  22. Student presentations

  23. Student presentations
• 24. Student presentations
• 25. Cholinesterase detemination, consultation
• 26. Cholinesterase determination, consultation
• 27. Cell cycle and cancer
• 28. Cell cycle and cancer

Seminars

Reading material

Obligatory literature

Nelson, Cox: Lehninger Principles of Biochemistry, 7th edition, W.H. Freeman, 2017.

Literature developed by the Department

http://aok.pte.hu/en/egyseg/oktatasianyagok/20
https://potepedia.aok.pte.hu/en

Notes

http://aok.pte.hu/en/egyseg/oktatasianyagok/20
https://potepedia.aok.pte.hu/en

Recommended literature

Berg, Tymoczko, Stryer: Biochemistry, 8th edition, W.H. Freeman, 2015.

Devlin: Textbook of Biochemistry with Clinical Correlations, 7th edition, Wiley, 2010.

Lieberman, Marks: Marks' Basic Medical Biochemistry - A Clinical Approach, 4th edition, Lippincott, 2013

Conditions for acceptance of the semester

No more than three absences from the laboratory practices.

Holding an oral presentation about a given disorder provided in the presentation topic list.
Take at least 10 of the 12 short tests to be written in the first 10 minutes of the exercises.
Achieving a minimum of 7 points during the tests.

Mid-term exams

Holding an oral presentation about a specific disorder from the presentation topic list.
Starting from week 3, there will be 12 short tests to write in the first 10 minutes of each exercise.

Making up for missed classes

None.

Exam topics/questions

http://aok.pte.hu/en/egyseg/oktatasianyagok/20
https://potepedia.aok.pte.hu/en

The semester ends with an oral semester exam that is preceded by a written test consisting of 7 questions from the minimum (MRT) questions. The score from the written part of the exam can be increased by 1-3 points earned through small presentations during the semester, so a maximum of 31 points can be achieved. Those who score at least 20 points out of the possible 31 on the MRT are eligible to draw a topic for the oral exam. Passing the Biochemistry final exam is not a requirement for taking the exam. However, those who have not passed the Biochemistry exam before the oral exam will have to take a make-up test from the MRT questions (185 questions with solved minimum equations for the academic year 2022-23) consisting of 10 questions, each worth 3 points. To pass, a minimum of 21 points must be scored. So, those who do not have a satisfactory grade in the Biochemistry course, will have to take two make-up tests before the oral exam, and both results must meet the minimum requirements. Extra points obtained during the semester can only be added to the seven-question MRT part of the colloquium exam.

After passing the written MRT test, the student draws an oral topic card that includes both A and B parts. The final grade is determined by the performance on the oral exam.

Examiners

• Agócs Attila
• Antus Csenge Petra
• Bagóné Vántus Viola
• Berente Zoltán
• Bognár Zita
• Debreceni Balázs
• Fekete Katalin
• Gallyas Ferenc
• Jávor-Hocsák Enikő
• Kálmán Nikoletta
• Kiss Bence
• Kőszegi Balázs
• Kovács Krisztina (Biokémia)
• Nagyné Kiss Gyöngyi
• Radnai Balázs (Biokémia)
• Szabó Aliz
• Takátsy Anikó
• Tapodi Antal
• Veres Balázs

Instructor / tutor of practices and seminars

• Antus Csenge Petra
• Bagóné Vántus Viola
• Berente Zoltán
• Bognár Zita
• Debreceni Balázs
• Fekete Katalin
• Jávor-Hocsák Enikő
• Kiss Bence
• Kőszegi Balázs
• Kovács Krisztina (Biokémia)
• Nagyné Kiss Gyöngyi
• Takátsy Anikó
• Tapodi Antal
• Veres Balázs