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Medical Applications of Mass Spectrometry

Data

Official data in SubjectManager for the following academic year: 2024-2025

Course director

Number of hours/semester

lectures: 20 hours

practices: 0 hours

seminars: 0 hours

total of: 20 hours

Subject data

  • Code of subject: OAF-TSS-T
  • 2 kredit
  • General Medicine
  • Optional modul
  • autumn
Prerequisites:

-

Course headcount limitations

min. 5 – max. 50

Topic

In medical sciences, emphasis is increasingly placed on instrumental techniques and accurate, quantitative measurements. This course is give an overall review about the modern mass spectrometry and it shows the medical applications of the MS in the clinical and diagnostic practice.

Topics:

Introduction to MS. Ionsources, analizators, detectors. Separation techniques. Sample handling. Biomedical sampling. Bioinformatics. Proteomics, metabolomics and lipidomics. Biomarker discovery. Mass spectrometric imaging techniques.

Lectures

  • 1. Introduction to mass spectrometry - Márk László
  • 2. Introduction to mass spectrometry - Márk László
  • 3. Ionsources - Márk László
  • 4. Analyzers - Márk László
  • 5. The mass spectrum. - Márk László
  • 6. Sample matrices, Sampling procedures. - Márk László
  • 7. Sample pretreatment, separation techniques. - Márk László
  • 8. Sample pretreatment, separation techniques. - Márk László
  • 9. Proteomics - Márk László
  • 10. Proteomics - Márk László
  • 11. Metabolomics - Márk László
  • 12. Metabolomics - Márk László
  • 13. Investigation of endocrine system - Márk László
  • 14. Investigation of endocrine system - Márk László
  • 15. Pathological biomarker discovery - Márk László
  • 16. Pathological biomarker discovery - Márk László
  • 17. Lipidomics - Márk László
  • 18. Lipidomics - Márk László
  • 19. Imaging mass spectrometry - Márk László
  • 20. Imaging mass spectrometry - Márk László

Practices

Seminars

Reading material

Obligatory literature

Literature developed by the Department

Lecture slides and notes.

Notes

Recommended literature

Vékey et al: Medical Applications of Mass Spectrometry, 2008.

Hoffman et al: Mass Spectrometry, 2007

Conditions for acceptance of the semester

Written exam. Max. absences: 20%.

Mid-term exams

Not possible.

Making up for missed classes

Not possible.

Exam topics/questions

Ionsources.

Analizators.

Detectors.

Separation techniques.

Sample handling. Biomedical sampling.

Bioinformatics.

Proteomics.

Metabolomics

Lipidomics.

Biomarker discovery.

Mass spectrometric imaging techniques.

MS of endocrine system.

Examiners

Instructor / tutor of practices and seminars

Rólunk