Microbiology 1

Data

Official data in SubjectManager for the following academic year: 2024-2025

Topic

Brief description of the topic: The introduction covers the subject and history of medical microbiology and its place in medicine. Morphology, physiology and genetics of microbes, as well as methods of disinfection and the theoretical aspects of antimicrobial therapy, are the subjects of the general microbiology lectures. The host-parasite interactions involved in the pathogenesis of various infections will be described, as well as the host defence mechanisms, the possibilities of immune prophylaxis, pathways of allergy, tolerance and autoimmunity. The first semester also includes systematic virology, which covers in detail infections of viral and prion etiologies.

The objective of the first semester is to provide students with solid knowledge and insight and to prepare them for later courses in systematic bacteriology, mycology, parasitology and clinical microbiology, as well as understanding clinical topics related to infections.

Lectures

• 1. Introduction I.: The subject and history of microbiology, taxonomy - Reuter Gábor Kamilló
• 2. Introduction II.: Earth and the human microbiome. Importance of microorganism in the Earth's biosphere - Reuter Gábor Kamilló
• 3. Morphology of bacteria. Essential bacterial cell components, - Emődy Levente
• 4. Accessorial bacterial cell components - Emődy Levente
• 5. The physiology of bacteria. Nutrition types and growth of bacteria - Kocsis Béla
• 6. Microbial genetics - Pál Tibor
• 7. Infection cycle, colonisation, infection, modes of transmission, host, source, vector - Emődy Levente
• 8. Pathogenicity and virulence, virulence factors, conventional and molecular Koch postulates - Emődy Levente
• 9. Endotoxins and exotoxins - Emődy Levente
• 10. Sterilization - Kerényi Monika
• 11. Disinfection - Kerényi Monika
• 12. Antibiotics - general introduction (action, groups of action, resistance mechanisms - Pál Tibor
• 13. Principles of antibiotic treatment, empirical, targeted, and prophylactic therapy, interactions, PK/PD - Pál Tibor
• 14. Inhibitors of cell wall biosynthesis I. - Pál Tibor
• 15. Inhibitors of cell wall biosynthesis II - Pál Tibor
• 16. Inhibitors of cell wall biosynthesis III. - Pál Ágnes Mária (Sonnevend)
• 17. Inhibitors of protein synthesis I: aminoglycosides, chloramphenicol, tetracyclines - Pál Ágnes Mária (Sonnevend)
• 18. Inhibitors of protein synthesis II.; macrolides, lincomycin, clindamycin; Membrane active agents; Metronidazole - Pál Ágnes Mária (Sonnevend)
• 19. Chemotherapy: sulfonamides, antimycobacterial drugs, quinolones, and nitrofurans - Pál Ágnes Mária (Sonnevend)
• 20. Characteristics of viruses (basic concepts, chemical composition, structure, classification); viral replication - Reuter Gábor Kamilló
• 21. Pathogenesis of viral infections (transmission modes and types of infection, acute and chronic viral infections) - Reuter Gábor Kamilló
• 22. Adenoviruses (serotypes, diseases); parvoviruses (parvovírus B19, bocavirus, bufavirus, parvovirus 4), anelloviruses - Reuter Gábor Kamilló
• 23. Herpesviruses I (HHV1, HHV2; HHV6, HHV7, HHV8) - Szereday László
• 24. Herpesviruses II (VZV/HHV3, EBV/HHV4, CMV/HHV5) - Szereday László
• 25. Papillomaviruses (HPV); polyomaviruses (JC, BK, MC, WU, and KI); slow virus infections (SSPE, PML); prion and prion diseases (Kuru, CJD, vCJD, GSS, FFI, MSA) - Reuter Gábor Kamilló
• 26. Hepatitis viruses (HAV, HBV, HCV, HDV, and HEV) - Reuter Gábor Kamilló
• 27. Poxviruses; Picornaviruses (enteroviruses, cardiovirus, cosavirus, kobuvirus, parechovirus, salivirus) - Reuter Gábor Kamilló
• 28. Orthomyxoviruses (Influenza A, B, C, and D viruses) - Szereday László
• 29. Paramyxoviruses: parainfluenza, mumps, morbilli, Pneumoviruses: human orthopneumovirus (respiratory syncytial virus /RSV), human metapneumovirus (hMPV), Nipah and Hendra viruses - Reuter Gábor Kamilló
• 30. Coronaviruses (SARS-CoV, MERS-CoV, SARS-CoV-2 and diseases); rubella virus (congenital rubella syndrome) - Reuter Gábor Kamilló
• 31. Viral gastroenteritis: gastroenteritis-causing viruses: rotaviruses, caliciviruses, astroviruses enteric adenoviruses - Reuter Gábor Kamilló
• 32. Arenaviruses (LCM, Lassa, Junin, Machupo, Guanarito, Sabia, Lujo); Hantaviruses; Nairoviruses (CCHF); Phenuiviruses (Rift Valley, Sandfly fever, SFTS); Rhabdoviruses (rabies) - Reuter Gábor Kamilló
• 33. Filoviruses (Marburgvirus, Ebolavirus); Flaviviruses (tick-borne encephalitis, West-Nile virus, yellow fever, Dengue, and Zika virus); Togaviruses (chikungunya) - Reuter Gábor Kamilló
• 34. HIV/AIDS and other human retroviruses (HTLV-I, HTLV-II) - Reuter Gábor Kamilló
• 35. Antiviral therapy - Reuter Gábor Kamilló
• 36. General immunological overview, mucosal immunity - Polgár Beáta
• 37. Defence against viruses and bacteria - Polgár Beáta
• 38. Defence against fungi and parasites - Polgár Beáta
• 39. Immunoprophylaxis, active and passive immunization, vaccines I - Szereday László
• 40. Immunoprophylaxis, active and passive immunization, vaccines II - Szereday László
• 41. Hypersensitivity tolerance - Polgár Beáta
• 42. Autoimmunity, post-infectious diseases - Polgár Beáta

Practices

• 1. Introduction, safety regulations. The microscope, wet mount and stained preparations
• ...

  2. Introduction, safety regulations. The microscope, wet mount and stained preparations

  3. Introduction, safety regulations. The microscope, wet mount and stained preparations
• 4. Introduction, safety regulations. The microscope, wet mount and stained preparations
• 5. Cultivation of bacteria, media
• ...

  6. Cultivation of bacteria, media

  7. Cultivation of bacteria, media
• 8. Cultivation of bacteria, media
• 9. Identification of bacteria
• ...

  10. Identification of bacteria

  11. Identification of bacteria
• 12. Identification of bacteria
• 13. Antibiotic sensitivity tests, MIC, antibiotic concentration in body fluids
• ...

  14. Antibiotic sensitivity tests, MIC, antibiotic concentration in body fluids

  15. Antibiotic sensitivity tests, MIC, antibiotic concentration in body fluids
• 16. Antibiotic sensitivity tests, MIC, antibiotic concentration in body fluids
• 17. Serology I
• 18. Serology I
• 19. Serology I
• 20. Serology I
• 21. Serology II, Molecular diagnostics
• ...

  22. Serology II, Molecular diagnostics

  23. Serology II, Molecular diagnostics
• 24. Serology II, Molecular diagnostics
• 25. Diagnostic virology
• ...

  26. Diagnostic virology

  27. Diagnostic virology
• 28. Diagnostic virology

Seminars

Reading material

Obligatory literature

Dr. Patrick R. Murray, Dr. Ken S. Rosenthal, and Dr. Michael A. Pfaller (eds.): Medical Microbiology, 8th edition, Elsevier Saunders 2020 ISBN13 (EAN): 9780323673228

Literature developed by the Department

Lectures on the Potepedia and the Teams

Notes

Departments website

Recommended literature

Michael Barer, Will Irving (eds.): Medical Microbiology 19e, Elsevier Churchill Livingstone, 2018, ISBN: 9780702072000

Carroll KC, Butel JS, Morse SA, Mitzner T. Jawetz, Melnick, and Adelbergs: Medical Microbiology, 28th edition, Lange Medical Book,McGraw-Hill Education - Europe 2019, ISBN:9780071824989

A.K. Abbas, A.H. Lichtman, S. Pillai: Cellular and Molecular Immunology, 9th edition, Elsevier Saunders, 2017, ISBN: 9780323479783

Galdwinn M, Trattler W.: Clinical Microbiology Made Ridiculously Simple, 7th edition, MedMaster Inc. 2019, ISBN-10: 1935660330

Conditions for acceptance of the semester

No

Mid-term exams

-

Making up for missed classes

Microbiology is taught through lectures and practicals. The Institute insists on active participation in practical sessions, as only there can the practical knowledge and skills necessary for the collection and handling of microbiological samples be acquired. A prerequisite for the signature - for the semester to be accepted - is that a student who misses a practical, if possible, make up for the missed class in another group in the same subject.

Exam topics/questions

At the end of the semester, students take a written exam. The Institute provides five dates for the exam and for the follow-up exams. The topics of the exam consist of lectures and practicals. It is important to note that the required knowledge is often not available in the textbook and manuals.

The written exam consists of multiple-choice questions on separate topics.

Examiners

• Emődy Levente
• Kerényi Monika
• Pál Ágnes Mária (Sonnevend)
• Pál Tibor
• Reuter Gábor Kamilló
• Szereday László

Instructor / tutor of practices and seminars

• Kerényi Monika
• Melegh Szilvia Zsóka
• Mestyán Gyula
• Pál Ágnes Mária (Sonnevend)
• Pál Tibor
• Schneider György József
• Szereday László
• Tigyi Zoltán