Molecular Cell Biology 2

Data

Official data in SubjectManager for the following academic year: 2026-2027

Topic

Molecular cell biology aims to introduce the molecular mechanisms of molecular biology and cell biology and to emphasise their importance in medicine. It provides the basis for teaching the different areas of molecular medicine, molecular pathology, molecular diagnostics, pharmacology and gene therapy. In the second semester of the course, we will discuss signalling pathways, apoptosis signalling, types of stem cells and their medical importance. In addition to the general characteristics of tumors, we will describe the characteristics of DNA and RNA tumor viruses involved in tumorigenesis, as well as the mechanisms of activation of cellular oncogenes and inactivation of tumor suppressor genes. In addition to the multistep mechanisms of tumor development, we will discuss the latest treatment options. At the end of the semester, we will summarize molecular diagnostic techniques, types of gene therapy and their importance in medical practice.
Course-related information is published in the Student Guide.

Lectures

• 1. Cellular connections - Bugyi Beáta
• 2. Passive and active transport processes - Bugyi Beáta
• 3. Extracellular matrix. Cell-extracellular matrix connections - Bugyi Beáta
• 4. Signal transduction 1. Signaling molecules and their receptors - Schipp Renáta
• 5. Signal transduction 2. Role of G-proteins in signaling - Feketéné Kiss Katalin
• 6. Signal transduction 3. Growth factor signaling - Sétáló György ifj.
• 7. Signal transduction 4. Stress signaling - Bátor Judit
• 8. Signal transduction 5. Cytokine- and integrin signaling - Berta Gergely
• 9. Signal transduction 6. TGFb-, Wnt-, Heghehog-, Notch signaling - Feketéné Kiss Katalin
• 10. Signal transduction 7. General conclusions, clinical aspects - Varga Judit
• 11. Types of cell death - Bátor Judit
• 12. Apoptosis pathways, physiological and pathological importance - Bátor Judit
• 13. Types of stem cells and their medical importance - Berta Gergely
• 14. General features of tumor cells and tumors - Varga Judit
• 15. DNA tumor viruses - Mikó Éva
• 16. RNA tumor viruses - Mikó Éva
• 17. Cellular oncogenes 1. - Varga Judit
• 18. Cellular oncogenes 2. - Bogdán Ágnes
• 19. Cellular oncogenes 3. - Bogdán Ágnes
• 20. Tumor suppressor genes 1. - Sétáló György ifj.
• 21. Tumor suppressor genes 2. - Sétáló György ifj.
• 22. Role of oncogenes in tumor formation - Sétáló György ifj.
• 23. Multistep carcinogenesis 1. Experimental carcinogenesis - Sétáló György ifj.
• 24. Multistep carcinogenesis 2. Clinical stages of cancers - Sétáló György ifj.
• 25. Therapy of tumors - Berta Gergely
• 26. Molecular diagnostics - Berta Gergely
• 27. Gene therapy 1. - Bátor Judit
• 28. Gene therapy 2. - Stayer-Harci Alexandra

Practices

• 1. Molecular biology methods 2. Nucleic acid isolation
• 2. Molecular biology methods 2. Nucleic acid isolation
• 3. Molecular biology methods 3. Restriction endonuclease digestion of human DNA
• 4. Molecular biology methods 3. Restriction endonuclease digestion of human DNA
• 5. Histochemistry and cytochemistry of macromolecules
• 6. Histochemistry and cytochemistry of macromolecules
• 7. Signaling
• 8. Signaling
• 9. Apoptosis
• 10. Apoptosis
• 11. Tumor biology
• 12. Tumor biology

Seminars

• 1. Cytoskeleton
• 2. Cell membrane, cell-cell junctions
• 3. Passive and active transport processes
• 4. Extracellular matrix, cell-extracellular matrix connections
• 5. Types of chemical signaling. Receptors
• 6. Signal transduction mechanism 1. cAMP pathway
• 7. Signal transduction mechanisms 2. Phospholipase C pathway. Growth factor and cytokine signaling
• 8. Apoptosis. Stem cells
• 9. General features of tumors
• 10. DNA and RNA tumor viruses
• 11. Cellular oncogenes
• 12. Tumor suppressor genes. Oncogenes and the cell cycle
• 13. Multistep mechanism of carcinogenesis
• 14. Therapy of tumors. Molecular medicine
• 15. End semester test
• 16. End semester test

Reading material

Obligatory literature

PotePedia materials

Materials uploaded to the MS Teams lecture group

Literature developed by the Department

PotePedia materials

Materials uploaded to the MS Teams lecture group

Moodle test questions

Notes

Molecular Cell Biology 2. Laboratory manual (e-book)

Szeberényi, J., M. Pap (editor): Molecular Cell Biology Syllabus

Recommended literature

Lodish et al.: Molecular Cell Biology

Alberts et al.: Molecular Biology of the Cell

Conditions for acceptance of the semester

Completion of all practices, confirmed by the instructor's signature. No more absences from seminars and practices than allowed. According to the application of the provision of Section 1/A (6) of the Code of Studies and Examinations to small group sessions (seminars, practices).

Mid-term exams

Mid-term and end-of-semester written tests. The dates and topics of the tests will be announced during the lecture and in the Molecular Cell Biology lecture Teams group. There is no possibility for retakes for any of the written tests. Based on the combined results of the mid-term tests, exemption from the exam can be obtained.

Making up for missed classes

Due to absences, make-up practicals can be attended at make-up sessions organized by the Department.

Mid-term tests can be made up according to the options designated by the course leader. There is no possibility to make up the end-of-semester test.

Exam topics/questions

Available on PotePedia and uploaded to the MS Teams lecture group.

Examiners

• Atlaszné Váczy Alexandra
• Balassa Tímea
• Balogh Bálint
• Bátor Judit
• Berta Gergely
• Bogdán Ágnes
• Bugyi Beáta
• Csabai-Tanics Tímea Judith
• Feketéné Kiss Katalin
• Gaszler Péter
• Horváth Marianna
• Mikó Éva
• Németh Marica
• Rátky Fanni
• Schipp Renáta
• Sétáló György ifj.
• Stayer-Harci Alexandra
• Szütsné Tóth Mónika Ágnes
• Tarjányi Oktávia
• Varga Judit

Instructor / tutor of practices and seminars

• KURZUSHOZ RENDELT OKTATÓ