Genetic Background of Gene Manipulation I

Data

Official data in SubjectManager for the following academic year: 2026-2027

Topic

The subject introduces the basics of genetics and the basic principles of inheritance (e.g. Mendelian and non-Mendelian inheritance, sex-linked inheritance, etc.). During the course, the properties, methodologies, and statistical background of linkage studies are discussed (e.g. allele frequency, Hardy-Weinberg equilibrium, etc.). The course describes the characteristics, structure, and variations of the genome of the important model animals used in biotechnology. The course gives an overview of the molecular mechanism and regulation of gene expression in prokaryotes and eukaryotes. The course presents the basic technologies applied in genetics; during the practice, students will become familiar with these methods.

Lectures

• 1. Introduction: Concepts of Genetics - Garai Kitti
• 2. Mitosis and meiosis I. - Garai Kitti
• 3. Mitosis and meiozis II. - Garai Kitti
• 4. Mendelian principles I - Garai Kitti
• 5. Mendelian principles II - Garai Kitti
• 6. Mendelian genetics - Garai Kitti
• 7. Independent assortment - Garai Kitti
• 8. Laws of probability - Garai Kitti
• 9. Patterns of inheritance - Garai Kitti
• 10. Extension of Mendelian genetics - alleles and sex lined inheritance - Garai Kitti
• 11. Chromosome mapping in Eukaryotes I. - Garai Kitti
• 12. Chromosome mapping in Eukaryotes II. - Garai Kitti
• 13. Genetic analysis and mapping in Bacteria and bacteriophages I. - Garai Kitti
• 14. Genetic analysis and mapping in Bacteria and bacteriophages II. - Garai Kitti
• 15. Sex determination and sex chromosomes - Garai Kitti
• 16. Chromosomal mutations I. - Garai Kitti
• 17. Chromosomal mutations II. - Garai Kitti
• 18. Extracellular inheritance - Garai Kitti
• 19. DNA structure, organization, replication and analysis I. - Garai Kitti
• 20. DNA structure, organization, replication and analysis II. - Garai Kitti
• 21. DNA replication and recombination I. - Garai Kitti
• 22. DNA replication and recombination II. - Garai Kitti
• 23. DNA organization in chromosomes I. - Garai Kitti
• 24. DNA organization in chromosomes II. - Garai Kitti
• 25. Genetic code and transcription - Garai Kitti
• 26. Genetic code and transcription II. - Garai Kitti
• 27. Translation and proteins I. - Garai Kitti
• 28. Translation and proteins II. - Garai Kitti

Practices

Seminars

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Reading material

Obligatory literature

Literature developed by the Department

Lecture ppt-s and seminar material based on the recommended literature

Notes

Recommended literature

Klug et al. - Concepts of Genetics 12th Edition

Benjamin A. Pierce - Genetics_ A Conceptual Approach 7th Edition (2020)

Conditions for acceptance of the semester

Midterm test - above 51%, regular attendance and cooperative work to lectures and seminars, documented on the attendance sheet.

Mid-term exams

One midterm test on the 6th week of the semester. If failed, two additional opportunities are provided for the students. The test is accepted if the student reached 51% on the test.

Making up for missed classes

Not possible

Exam topics/questions

Exam topics will be available on Teams and cover the topic list.

Examiners

Instructor / tutor of practices and seminars

• Ádám Zoltán Mihály
• Draskóczi Lilla Gréta
• Garai Kitti
• KURZUSHOZ RENDELT OKTATÓ