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Student Researchers' Society Topics

Student Researchers' Society Topics

Co-supervisor: Dr. TAMÁS, Viktória

Sports related concussion and repeated mild traumatic brain injury may be responsible for disturbances in brain function, even in the absence of gross anatomical lesions, and may have long-term health consequences. Advanced magnetic resonance imaging methods as diffusion-weighted MRI provide a powerful tool for investigating alterations in white matter microstructure, as e.g. diffuse axonal injury. This advanced MRI study as a Student Researchers' Society topic aims to reveal the afformentioned microstructural changes in contact-, semi-contact and non-contact sport athlets.

Co-supervisor: Dr. BOTZ, Bálint

In this study we explore the role of advanced multimodal ultrasound imaging in the diagnosis of peripheral artery disease. Our primary objective is to identify and evaluate novel imaging parameters obtainable using CEUS and microvascular flow imaging (MVFI), with particular focus on tissue perfusion, vascular density, and microcirculation. These ultrasound-derived parameters will be compared with findings from digital subtraction angiography (DSA), computed tomography (CT), and, where available, magnetic resonance (MR) examinations, as well as with clinical parameters describing disease severity and patient status. The study aims to determine the clinical utility of CEUS and MVFI, including their sensitivity and specificity, and to assess their potential contribution to disease characterization and outcome prediction. We expect these advanced ultrasound techniques to provide additional clinically relevant information on tissue perfusion and microvascular status.

Co-supervisor: Dr. SZUKITS, Sándor

In acute ischemic stroke, arterial occlusion leads to reduced cerebral blood flow and subsequent brain tissue injury. CT perfusion imaging provides information not only on regional cerebral perfusion but also on changes in vascular permeability, which may reflect blood-brain barrier disruption.

The aim of this study is to investigate whether permeability-related parameters derived from CT perfusion imaging are associated with the subsequent development of hemorrhagic transformation. Hemorrhagic complications significantly increase morbidity and mortality in stroke patients.

The study will retrospectively and prospectively analyze CT perfusion data of patients with acute ischemic stroke and correlate these findings with follow-up CT or MRI examinations to assess the presence and severity of hemorrhagic transformation. The ultimate goal is to develop a clinically applicable predictive model to support risk stratification prior to reperfusion therapy.

Methods

  • Analysis of stroke CT data (NCCT + CTP ± CTA)
  • Evaluation of permeability-related parameters
  • Assessment of hemorrhagic transformation based on follow-up CT/MR imaging
  • Statistical analysis: ROC analysis, logistic regression, multivariable modeling

Student tasks

  • Organization and management of imaging data
  • Evaluation of perfusion and permeability maps
  • Database construction
  • Interpretation of results and preparation of the TDK thesis

Required background / competencies

  • Proficiency in English
  • Basic statistical knowledge
  • Interest in diagnostic imaging

Expected outcomes / relevance

  • Identification of predictive markers for hemorrhagic transformation
  • Potential publication and presentation at TDK/KTDK conferences

Co-supervisor: Dr. BOTZ, Bálint

Low dose whole body EOS x-ray imaging is a relatively novel technique that has an increasing role in the evaluation and follow-up of childhood spine deformities. This type of imaging depicts not only the axial and skeletal bony structures but also the torso and the chest. Therefore incidental findings unrelated to the main diagnosis are often encountered. According to empirical evidence these are mainly skeletal abnormalities in the examined pediatric population. The aim of this work is to retrospectively evaluate and assess these newly identified incidental findings encountered during diagnostic whole-body low dose x-ray exams. Since EOS is a recently developed technique knowledge of the incidence and type of incidental findings in the imaged population could be of great use in aiding the routine diagnostic work.
 

Co-supervisor: Dr. JÁRAY, Ákos

The significance of contrast-enhanced ultrasound examinations (CEUS) in the evaluation of focal lesions of parenchymal organs (e.g. liver, kidney) is steadily increasing. In the daily clinical practice our main task is most often to differentiate between benign and malignant lesions, based on enhancement kinetics. In select cases specific lesion subtypes can also be identified. During the examination, the influx of the contrast agent, the lesion-specific vascular structure and perfusion pattern can be dynamically followed. Nonetheles, in clinical practice CEUS examinations are typically evaluated subjectively. However, with the help of appropriate evaluation software, the enhancement pattern and kinetics can be quantified from the raw image data, and the enhancement pattern of the lesion can be compared to that of the surrounding normal tissues. In this study, we analyze CEUS examinations performed at our own institution that are suitable for this purpose, together with the related cross-sectional imaging modalities (CT/MRI) and clinical data. Our aim is to determine the quantitative characteristics of the different lesion types and to investigate the significance of quantitative CEUS in the characterization of the above lesions. Student research fellows will have the opportunity to become familiar not only with CEUS but also with other related diagnostic methods, as well as to participate in data collection, software-based quantification, statistical evaluation, and review of the relevant literature.