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KARÁDI, Zoltán

KARÁDI, Zoltán

M.D. Ph.D.

emeritus professor

Institute of Physiology

Telefon: *36433

Supervisor of the following TDK topics

Supervisor: KARÁDI, Zoltán

Compared to the other sensory modalities, gustation is of distinguished significance in the adaptive control of food and fluid intake behaviors. With respect to this, the limbic forebrain taste information processing appears to be especially important. For studying these processes, to a better understanding of the neuronal background of the above functions, extracellular single neuron recordings are to be conducted during gustatory stimulations, as well as taste associated learning and other behavioral tests are to be performed.

Supervisor: KARÁDI, Zoltán

Co-supervisor: Dr. SZABÓ, István

Complex neurochemical (microelectrophoretic administration of catecholamines, neuropeptides, interleukin 1β, etc.) and behavioral (monkey, conditioned alimentary task) microelectrophysiological experiments for the feeding and motivation (hunger, satiety) as well as metabolic state (obesity, diabetes mellitus) associated functional characterization of limbic forebrain (orbitofrontal cortex, cingulate cortex, etc.) glucose-monitoring neurons.

Supervisor: KARÁDI, Zoltán

The research program summarizes our multiple neurophysiological experiments to functionally characterize the glucose-monitoring (GM) neuronal network substantial in the central regulation of feeding, body weight, and metabolism. Extracellular single neuron recording, neurochemical-biochemical and behavioral investigations are planned in the laboratory rat as well as in the rhesus monkey, phylogenetically close to the human being. The target areas of the experiments are the limbic forebrain structures in which the homeostatic significance of the GM neurons is to be elucidated. Successful accomplishment of the program serves the better understanding of the central regulation of feeding and metabolism and that of diseases (obesity, diabetes mellitus, etc.) developing after pathological alterations of these functions and causing escalating social and financial problems worldwide.