Proteins and Peptides in Pharmacology

Data

Official data in SubjectManager for the following academic year: 2025-2026

Topic

The course describes the pharmacological role of proteins and peptides. The character and various functions of these biopolymers are featured on the basis of structural considerations. Besides the usual discussion according to biochemical and physiological classifications, an emphasis is placed on the introduction of the corresponding methodologies, as well. In Journal Club sessions, recent research articles will be featured with the students to deepen their knowledge in the areas discussed during the previous lectures. In this way, the students can discover further connections themselves and make sure of the usefulness of their newly obtained knowledge on proteins and peptides. The lectures will take place weekly or (if possible) contracted into 4 blocks.

Lectures

• 1. General properties and classification - Hetényi Csaba
• 2. Building blocks - Hetényi Csaba
• 3. Synthesis and biosynthesis - Hetényi Csaba
• 4. Purification and analysis - Hetényi Csaba
• 5. Structural levels and folding - Hetényi Csaba
• 6. Architecture, motifs and domains - Hetényi Csaba
• 7. Structure determination (experimental) - Hetényi Csaba
• 8. Structure determination (theoretical) - Hetényi Csaba
• 9. Structural basis of protein function 1. Recognition - Hetényi Csaba
• 10. Structural basis of protein function 2. Mechanisms - Hetényi Csaba
• 11. Journal club 1. Normal and mis-function - Hetényi Csaba
• 12. Journal club 2. Pathological conformations - Hetényi Csaba
• 13. Regulation 1. Effectors and switches - Hetényi Csaba
• 14. Regulation 2. Post-translational modifications - Hetényi Csaba
• 15. Structural and motor proteins. Transporters - Hetényi Csaba
• 16. Molecular dynamics of proteins - Hetényi Csaba
• 17. Linking sequence to function 1. Alignments and homologies - Hetényi Csaba
• 18. Linking sequence to function 2. Disordered proteins, metastable folds - Hetényi Csaba
• 19. Endogenous and exogenous peptides, peptidomimetics - Hetényi Csaba
• 20. Protein ligands - Hetényi Csaba
• 21. Journal club 3. Enzymes in pharmacology - Hetényi Csaba
• 22. Journal club 4. Receptors in pharmacology - Hetényi Csaba
• 23. Test - Hetényi Csaba
• 24. Test - Hetényi Csaba

Practices

Seminars

Reading material

Obligatory literature

Literature developed by the Department

The material of the course including pdfs of lectures and lists of questions will be made downloadable from the web site of the Department of Pharmacology and Pharmacotherapy or a link will be provided during the lectures / in an e-mail.

Notes

Recommended literature

Conditions for acceptance of the semester

Jelenleg a választható és elektív kurzusok esetén a szabályzat nem tartalmaz részvételi követelményt. Amennyiben szükséges itt valamit megjelölnöm, akkor 25 %, de csak azért teszem, hogy kitölthető legyen az űrlap. Javasoltam a Tanulmányi Bizottság vezetőjének a helyzet szabályzását és 50 % mértéket a hiányzásoknál.

Mid-term exams

There is a final test announced at the end of the semester. The test will include multiple choice questions and short essays. A mark is offered according to the results of the written test and optionally by evaluation of the student's presentation prepared for the Journal Club. The student can improve the mark according to university regulations.

Making up for missed classes

Replacement is possible according to personal consultation.

Exam topics/questions

Lists of questions will be provided at the end of each lecture specifying the required knowledge.

Examiners

Instructor / tutor of practices and seminars