Introduction to Bioinformatics - Theory

Data

Official data in SubjectManager for the following academic year: 2025-2026

Topic

The course provides a general introduction to Bioinformatics. A survey of practical applications follows a brief theoretical overview for each sub-topic. Handling of genomic and structural data and the corresponding file types are introduced. A special emphasis is placed on structure-based drug design methodologies. Basic skills are practiced for each topic in the computer lab. The course is mostly based on open-source or free software, and the students are encouraged by homework to improve their computer skills further on their personal computers. Journal Club sessions supply additional up-to-date research results in bioinformatics and contribute to improving the presentation skills of the students.

Lectures

• 1. The bioinformatics toolkit - Hetényi Csaba
• 2. Databases - Börzsei Rita Judit
• 3. The decoding of prokaryotic and eukaryotic genomes - Rauch Tibor Attila
• 4. The functional analysis of genomes and epigenomes - Rauch Tibor Attila
• 5. Comparative genome (DNA and RNA) analyses - Rauch Tibor Attila
• 6. Molecular structure and visualization - Hetényi Csaba
• 7. Structural measurements and manipulations - Börzsei Rita Judit
• 8. Building of ligands (drugs) - Hetényi Csaba
• 9. Building of targets (proteins) - Biskup Dóra
• 10. Molecular docking - Hetényi Csaba
• 11. Structure-based drug design and molecular dynamics - Hetényi Csaba
• 12. Descriptive and basic statistics - Hetényi Csaba
• 13. Pharmacoinformatics - Zsidó Balázs Zoltán
• 14. Journal club, test - Hetényi Csaba

Practices

Seminars

Reading material

Obligatory literature

Literature developed by the Department

The material of the course including pdfs of lectures and lists of questions will be made downloadable from the website of the Department of Pharmacology and Pharmacotherapy or from TEAMS or a link will be provided during the lectures / in an e-mail.

Notes

Recommended literature

Paul M. Selzer, Richard J. Marhöfer, Oliver Koch
Applied Bioinformatics

Conditions for acceptance of the semester

- Test writing accomplished
- Journal Club presentation accomplished

Mid-term exams

There is a final test announced at the end of the semester. The test will include multiple choice questions or short essays. A mark is offered according to the results of the written test AND by evaluation of the student's presentation prepared for the Journal Club. The student can improve the mark according to university regulations.

Making up for missed classes

Replacement is not possible.

Exam topics/questions

Lists of questions will be provided for each lecture in PDF format.

Examiners

• Börzsei Rita Judit
• Hetényi Csaba
• Rauch Tibor Attila

Instructor / tutor of practices and seminars

• Biskup Dóra
• Börzsei Rita Judit
• Deák Péter (Biokémia)
• Hetényi Csaba
• Rauch Tibor Attila
• Zsidó Balázs Zoltán