Pharmacology and Biotechnology in Medical Practice

Data

Official data in SubjectManager for the following academic year: 2026-2027

Topic

The aims of the course are: showing the history of the drug research and modes of the drug development, presenting information about the phases of rational drug design, from the plan of the molecules to clinical trials.The aim of the course is to provide an overview of drug development and introduce its methodology. The students will hear about rational drug design, starting from molecular design to clinical tirals. General pharmacology: Farmakokinetics, absorption, repartition, biotransformation, excretion. Farmakodinamics, drug binding targets, receptors, efficacy studies. Detection of the effects at various levels (molecular, cell, organ, organism). Dose dependency. Drug selectivity and safety. Tolerance. Drug interactions. Products suitable for gene therapy and their pharmacological characteristics. Immune pharmacology: target molecules of biotechnological products that influence the immune system. We will talk about what is the reason of drug development, about the history of drug development. We will compare the traditional drug discovery and modern drug development. Students will learn about target identification and validation, drug design and synthesis, selection and testing of lead molecules. They will learn about in vitro, ex vivo and in vivo preclinical drug development and in vivo animal models od pain, behavioral studies, depression and anxiety. They will learn about clinical phase trials.. Production and quality control of cellular products suitable for human therapy.

Lectures

• 1. History of drugs - Szőke Éva
• 2. History of drugs - Szőke Éva
• 3. Strategies of drug development - Szőke Éva
• 4. Strategies of drug development - Szőke Éva
• 5. Target validation - Szőke Éva
• 6. Target validation - Szőke Éva
• 7. High throughput screening - Szőke Éva
• 8. High throughput screening - Szőke Éva
• 9.

  Preclinical testing, in vitro testing

  - Szőke Éva
• 10.

  Preclinical testing, ex vivo testing

  - Szőke Éva
• 11.

  Preclinical testing, in vivo models in anaesthetized animals

  - Szőke Éva
• 12.

  Preclinical testing in vivo tsest on conscoius animals

  - Szőke Éva
• 13.

  Mechanisms of drug actions

  - Szőke Éva
• 14.

  Mechanisms of drug actions

  - Szőke Éva
• 15.

  Quantitative pharmadynamics

  - Szőke Éva
• 16.

  Quantitative pharmadynamics

  - Szőke Éva
• 17. Pharmacokinetic aspects of drug development - Csekő Kata
• 18. Pharmacokinetic aspects of drug development - Csekő Kata
• 19. Pharmacokinetic aspects of drug development - Csekő Kata
• 20. Pharmacokinetic aspects of drug development - Csekő Kata
• 21.

  Preclinical investigations, behavoiural examinations

  - Szőke Éva
• 22.

  Preclinical investigations, behavioural examinations

  - Szőke Éva
• 23. Human phase studies - Szőke Éva
• 24. Human phase studies - Szőke Éva
• 25. Human phase studies - Szőke Éva
• 26. Human phase studies - Szőke Éva
• 27. GMP, GLP, GCP - Szőke Éva
• 28. GMP, GLP, GCP - Szőke Éva

Practices

Seminars

Reading material

Obligatory literature

Literature developed by the Department

Materials is pdf format.

Notes

Recommended literature

1. Povl Krogsgaard-Larsen, Tommy Liljefors, Ulf Madsen: Textbook of Drug Design and Discovery, 3rd edition, New York, Oxford University Press

2. Edward Harvel Kerns, Li Di: Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization, Academic Press, 2008

3. Ronald P. Evens: Drug and Biological Development: From Molecule to Product and Beyond, Springer, 2007

4. Rick Ng: Drugs: From Discovery to Approval, 2nd edition, Wiley-Blackwell, 2008

5. Bert Spilker: Guide to Drug Development: A Comprehensive Review and Assessment, Kluwer, 2008

6.Textbook of Drug Design and Discovery, Third Edition by Povl Krogsgaard-Larsen, Tommy Liljefors, Ulf Madsen, New York, Oxford University Press, 2. Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization by Edward Harvel Kerns, Li Di, Academic Press, 2008; 3. Drug and Biological Development: From Molecule to Product and Beyond by Ronald P. Evens, Springer, 2007; 4. Drugs: Fro

Conditions for acceptance of the semester

Obtaining a satisfactory grade in the written exam

Mid-term exams

none

Making up for missed classes

none

Exam topics/questions

written test

Examiners

• Szőke Éva

Instructor / tutor of practices and seminars

• Csekő Kata
• Szőke Éva