Pharmacology 1

Data

Official data in SubjectManager for the following academic year: 2024-2025

Topic

The general aim of the subject is to provide the dentistry students with all the basic information in pharmacology necessary to understand the actions of drugs and the clinical pharmacotherapy. Pharmacology can be defined as the study of the manner in which the function of living systems is affected by chemical agents. Therefore, the students should be familiar with the basic knowledge of the physiological, pathophysiological and biochemical background of the pharmacological and therapeutic approaches. On the other hand, drug therapy is closely related to the clinical aspects of diseases.

The following topics will be dealt with. Definitions, prescription writing, drug development, drug formulations. General aspects of mechanisms of drug actions: characterization of drug-receptor interactions, mechanisms of drug antagonism, signal transduction mechanisms of drug receptors. General and quantitative aspects of pharmacokinetics: absorption, distribution and elimination of drugs. Pharmacology of the autonomic nervous system. Local anaesthetics.

Cardiovascular pharmacology: drugs used to treat congestive heart failure, antianginal, antiarrhythmic, antihypertensive drugs, diuretics, calcium channel blockers, drugs acting on the renin-angiotensin-aldosterone system. Drugs affecting haemostasis, haematopoesis and hyperlipoproteinaemias. Pharmacology of histamine, serotonin. Principles of immunopharmacology.

Lectures

• 1. Introduction to the pharmacology of the autonomic nervous - Tamasikné Helyes Zsuzsanna
• 2. Cholinergic agonists, cholinesterase inhibitors - Tamasikné Helyes Zsuzsanna
• 3. Muscarine receptor antagonists - Tamasikné Helyes Zsuzsanna
• 4. Peripheral muscle relaxants - Tamasikné Helyes Zsuzsanna
• 5. Drugs acting on synthesis, storage, release and elimination of catecholamines - Tamasikné Helyes Zsuzsanna
• 6. Adrenergic receptor agonists - Tamasikné Helyes Zsuzsanna
• 7. Adrenergic receptor antagonists - Sánticsné Pintér Erika
• 8. Sulfonamides, trimethoprim. Fluoroquinolones - Tamasikné Helyes Zsuzsanna
• 9. Beta lactam antibiotics I - Sánticsné Pintér Erika
• 10. Beta lactam antibiotics II. Glycopeptide antibiotics - Sánticsné Pintér Erika
• 11. Tetracyclines, chloramphenicol, linezolid, clindamycin, metronidazole - Tamasikné Helyes Zsuzsanna
• 12. Aminoglycosides. Macrolides - Tamasikné Helyes Zsuzsanna
• 13. Anticancer drugs I - Sánticsné Pintér Erika
• 14. Anticancer drugs II - Sánticsné Pintér Erika

Practices

Seminars

• 1. Introduction to pharmacology
• 2. Drug development
• 3. Basic mechanisms of drug effects. Characteristics of the agonist-receptor interaction I
• 4. Characteristics of the agonist-receptor interaction II
• 5. Signal transduction. Tachyphylaxis and tolerance
• 6. Antagonism
• 7. Consultation on pharmacodynamics
• 8. Absorption and distribution
• 9. Biotransformation and excretion
• 10. Quantitative pharmacokinetics
• 11. Consultation on pharmacokinetics
• 12. Histamine and histamine receptor antagonists
• 13. Serotonin, 5-HT receptor agonists and antagonists I
• 14. Serotonin, 5-HT receptor agonists and antagonists II
• 15. Consultation on the pharmacology of the autonomous nervous system
• 16. Eicosanoids I
• 17. Eicosanoids II
• 18. Drugs acting on smooth muscle
• 19. Local anaesthetics I
• 20. Local anaesthetics II
• 21. Antituberculotics. Treatment of leprosy
• 22. Antifungal drugs
• 23. Antiviral drugs I
• 24. Antiviral drugs II
• 25. Antiseptics and disinfectants
• 26. Consultation on antimicrobial chemotherapy
• 27. Cytotoxic and embryotoxic adverse effects of drugs. Drug allergy
• 28. Drug interactions

Reading material

Obligatory literature

Rang, Dale,B. Ritter, Moore: Pharmacology, 8th edition, Elsevier Churchill Livingstone, 2015.

G. Katzung (ed.): Basic and Clinical Pharmacology, 12th edition, Lange Medical Books/McGraw-Hill, 2012.

Literature developed by the Department

Intranet. Department of Pharmacology and Pharmacotherapy. Educational materials.

MeetStreet

Notes

Recommended literature

Conditions for acceptance of the semester

For the semester to be accepted total absence should be less than 3 lectures or 6 seminars. Exceeding the absence limit of either lectures or seminars results in the semester not being accepted.

Mid-term exams

There is no mid-term exam.

Making up for missed classes

Not possible

Exam topics/questions

1. Drug development

2. Basic mechanisms of drug effects

3. Characteristics of the agonist-receptor interaction

4. Signal transduction

5. Tachyphylaxis and tolerance. Antagonism

6. Absorption

7. Distribution

8. Biotransformation

9. Excretion

10. Quantitative pharmacokinetics

11. Cholinergic agonists. Cholinesterase inhibitors

12. Muscarine receptor antagonists

13. Peripheral muscle relaxants

14. Drugs acting on the synthesis, storage, release and elimination of catecholamines

15. Adrenergic receptor agonists

16. Adrenergic receptor antagonists

17. Histamine and histamine receptor antagonists

18. Serotonin, 5-HT receptor agonists and antagonists

19. Eicosanoids

20. Drugs influencing smooth muscles

21. Local anaesthetics

22. Sulfonamides, trimethoprim. Fluoroquinolones

23. β-lactam antibiotics. Glycopeptide antibiotics

24. Tetracyclines, chloramphenicol, linezolid, clindamycin, metronidazole

25. Aminoglycosides. Macrolides

26. Antituberculotics

27. Antifungal drugs

28. Antiviral drugs

29. Antiseptics and disinfectants

30. Anticancer drugs: alkylating agents, antimetabolites

31. Anticancer drugs: antibiotics, alkaloids, hormones, biological therapy

32. Cytotoxic and embryotoxic adverse effects of drugs. Drug allergy

33. Drug interactions

Examiners

• Bölcskei Kata
• Pozsgai Gábor
• Sánticsné Pintér Erika
• Tamasikné Helyes Zsuzsanna

Instructor / tutor of practices and seminars

• Bátai István Zoárd (Farmakológia)
• Bölcskei Kata
• Csekő Kata
• Horváth Ádám István (Farmakológia)
• Hunyady Ágnes
• Pozsgai Gábor
• Sánticsné Pintér Erika
• Tamasikné Helyes Zsuzsanna