Pharmacology 2

Data

Official data in SubjectManager for the following academic year: 2024-2025

Topic

The general aim of the subject is to provide the dentistry students with all the basic information in pharmacology necessary to understand the actions of drugs and the clinical pharmacotherapy. Pharmacology can be defined as the study of the manner in which the function of living systems is affected by chemical agents. Therefore, the students should be familiar with the basic knowledge of the physiological, pathophysiological and biochemical background of the pharmacological and therapeutic approaches. On the other hand, drug therapy is closely related to the clinical aspects of diseases.

The following topics will be dealt with. Opioid analgesic drugs, cyclooxygenase inhibitors. Pharmacology of the central nervous system: general anaesthetics, antipsychotic drugs, antidepressants, antianxiety and hypnotic drugs, antiepileptics, treatment of neurodegenerative disorders, drug abuse and dependence. Pharmacology of the respiratory and the gastrointestinal tract. Pharmacology of the endocrine system: pituitary hormones, corticosteroids, reproductive system, thyroid hormones, antithyroid drugs, insulin, glucagon and oral hypoglycemic agents, vitamin D, treatment of osteoporosis. Chemotherapy: sulphonamides and trimethoprim, fluoroquinolones, beta-lactam antibiotics, aminoglycosides, antituberculotics. Antifungal drugs, antiviral agents, antiseptics and disinfectants.

Lectures

• 1. General anaesthetics I - Tamasikné Helyes Zsuzsanna
• 2. General anaesthetics II - Tamasikné Helyes Zsuzsanna
• 3. Anxiolytic and hypnotic drugs - Sánticsné Pintér Erika
• 4. Antipsychotics - Tamasikné Helyes Zsuzsanna
• 5. Antidepressants - Tamasikné Helyes Zsuzsanna
• 6. Antiepileptics - Pozsgai Gábor
• 7. Opioid analgesics I - Pozsgai Gábor
• 8. Opioid analgesics II - Pozsgai Gábor
• 9. Calcium channel blockers - Tamasikné Helyes Zsuzsanna
• 10. Drugs acting on the renin-angiotensin-aldosterone system - Sánticsné Pintér Erika
• 11. Diuretics - Pozsgai Gábor
• 12. Therapy of congestive heart failure - Tamasikné Helyes Zsuzsanna
• 13. Antianginal drugs - Sánticsné Pintér Erika
• 14. Pharmacotherapy of hypertension - Sánticsné Pintér Erika

Practices

Seminars

• 1. Pharmacotherapy of neurodegenerative disorders. Centrally acting muscle relaxants
• 2. Hypothalamic and pituitary hormones
• 3. Thyroid hormones, antithyroid drugs
• 4. Corticosteroids I
• 5. Corticosteroids II
• 6. Estrogens, anti-estrogens, progestogens, antiprogestogens. Postmenopausal hormone replacement therapy
• 7. Hormonal contraceptives. Androgens, anabolic steroids and antiandrogens
• 8. Parathormone, calcitonin, vitamin D and pharmacotherapy of osteoporosis
• 9. Insulin, insulin analogues
• 10. Oral antidiabetics. Glucagon
• 11. Pharmacotherapy of hyperlipoproteinemias
• 12. Drugs acting on the respiratory system I
• 13. Drugs acting on the respiratory system II
• 14. Consultation on the pharmacology of the central nervous system
• 15. Pharmacotherapy of peptic ulcer
• 16. Emetics, anti-emetics, prokinetic drugs
• 17. Laxatives, antidiarrhoeal drugs
• 18. Choleretic and cholekinetic drugs. Drugs protecting the liver. Pharmacotherapy of inflammatory bowel disease
• 19. Anti-arrhythmic drugs
• 20. Drugs influencing haemostasis I
• 21. Drugs influencing haemostasis II
• 22. Drugs influencing haematopoiesis
• 23. NSAIDs I
• 24. NSAIDs II. Pharmacotherapy of gout
• 25. Immunosuppressants
• 26. Immunosuppressants. Pharmacotherapy of rheumatoid arthritis
• 27. Drug abuse I
• 28. Drug abuse II

Reading material

Obligatory literature

Rang, Dale, Ritter, Moore: Pharmacology, 8th edition, Elsevier Churchill Livingstone, 2015.

B. G. Katzung (ed.): Basic and Clinical Pharmacology, 12th edition, Lange Medical Books/McGraw-Hill, 2012.

Literature developed by the Department

Intranet. Department of Pharmacology and Pharmacotherapy. Educational materials.

MeetStreet

Notes

Recommended literature

Conditions for acceptance of the semester

For the semester to be accepted total absence should be less than 3 lectures or 6 seminars. Exceeding the absence limit of either lectures or seminars results in the semester not being accepted.

Mid-term exams

There is no mid-term examination.

Making up for missed classes

Not possible

Exam topics/questions

1. Drug development

2. Basic mechanisms of drug effects

3. Characteristics of the agonist-receptor interaction

4. Signal transduction

5. Tachyphylaxis and tolerance. Antagonism

6. Absorption

7. Distribution

8. Biotransformation

9. Excretion

10. Quantitative pharmacokinetics

11. Cholinergic agonists. Cholinesterase inhibitors

12. Muscarine receptor antagonists

13. Peripheral muscle relaxants

14. Drugs acting on the synthesis, storage, release and elimination of catecholamines

15. Adrenergic receptor agonists

16. Adrenergic receptor antagonists

17. Histamine and histamine receptor antagonists

18. Serotonin, 5-HT receptor agonists and antagonists

19. Eicosanoids

20. Drugs influencing smooth muscles

21. Local anaesthetics

22. Sulfonamides, trimethoprim. Fluoroquinolones

23. β-lactam antibiotics. Glycopeptide antibiotics

24. Tetracyclines, chloramphenicol, linezolid, clindamycin, metronidazole

25. Aminoglycosides. Macrolides

26. Antituberculotics. Antileprotics

27. Antifungal drugs

28. Antiviral drugs

29. Antiseptics and disinfectants

30. Anticancer drugs: alkylating agents, antimetabolites

31. Anticancer drugs: antibiotics, alkaloids, hormones, biological therapy

32. Cytotoxic and embryotoxic adverse effects of drugs. Drug allergy

33. Drug interactions

34. General anaesthetics

35. Anxiolytic and hypnotic drugs

36. Antipsychotics

37. Antidepressants

38. Antiepileptic drugs. Centrally acting muscle relaxants

39. Pharmacotherapy of neurodegenerative disorders

40. Opioid analgesics: morphine and codeine

41. Opioid analgesics: semisynthetic, synthetic drugs and antagonists

42. NSAIDs: aspirin and paracetamol. Pharmacotherapy of gout

43. NSAIDs except aspirin and paracetamol

44. Calcium channel blockers

45. Drugs acting on the renin-angiotensin-aldosterone system

46. Diuretics

47. Pharmacotherapy of congestive heart failure

48. Antianginal drugs

49. Pharmacotherapy of hypertension

50. Anti-arrhythmic drugs

51. Pharmacotherapy of hyperlipoproteinemias

52. Drugs influencing haemostasis

53. Drugs influencing haematopoiesis

54. Drugs acting on the respiratory system: pharmacotherapy of bronchial asthma

55. Drugs acting on the respiratory system: Pharmacotherapy of allergic rhinitis. Antitussive, expectorant and mucolytic drugs

56. Pharmacotherapy of peptic ulcer

57. Emetics, anti-emetics, prokinetic drugs

58. Laxatives, antidiarrhoeal drugs. Choleretic and cholekinetic drugs. Drugs protecting the liver. Pharmacotherapy of inflammatory bowel disease

59. Hypothalamic and pituitary hormones

60. Thyroid hormones and antithyroid drugs

61. Corticosteroids

62. Estrogens, anti-estrogens, progestogens, antiprogestogens

63. Postmenopausal hormone replacement therapy. Hormonal contraceptives

64. Androgens, anabolic steroids and anti-androgens

65. Parathormone, calcitonin, vitamin D and pharmacotherapy of osteoporosis

66. Insulin, insulin analogues. Oral antidiabetic drugs. Glucagon

67. Immunosuppressants. Immunomodulators. Pharmacotherapy of rheumatoid arthritis

68. Drug abuse: General aspects. Opioids, central nervous system depressants

69. Drug abuse: psychomotor stimulants, hallucinogens, cannabis

Examiners

• Bölcskei Kata
• Pozsgai Gábor
• Sánticsné Pintér Erika
• Tamasikné Helyes Zsuzsanna

Instructor / tutor of practices and seminars

• Bátai István Zoárd (Farmakológia)
• Bölcskei Kata
• Csekő Kata
• Horváth Ádám István (Farmakológia)
• Hunyady Ágnes
• Pozsgai Gábor
• Sánticsné Pintér Erika
• Tamasikné Helyes Zsuzsanna