Iron Metabolism: from Molecular Mechanisms to Clinical Consequences

Data

Official data in SubjectManager for the following academic year: 2023-2024

Topic

During the course we will discuss the role of iron in the metabolism. We will deal with the iron demand of microorganisms and with the role of iron in the protective mechanisms against bacterial infections. We will discuss the possibilities of iron uptake and intracellular iron utilistaion, especially heme synthesis, and the syntesis of iron-sulfur clusters. The iron storage and iron mobilization from stores will be discussed in details. We reveal the functions of iron regulatory factors, their crosstalks, and the functions of the iron-containing proteins. Based on the brand new literature we discuss the the positive and negative regulators of the master iron regulator hepcidin. During the course we will deal with the different types of iron disorders and diseases (anemias, thalassemias, secondary iron overload, hemochromatosis) their genetic background, and therapeutic approaches. Based on the most actual findings the role of iron in the developpment of neurodegenerative diseases (Parkinson's disease, Alzheimer's disease and Huntington's disease) will be also discussed.

Lectures

• 1. Solution chemistry of iron - Jánosa Gergely
• 2. Interactions between iron other metal ions - Jánosa Gergely
• 3. The Importance of Iron for Biological Systems: haemoproteins, iron-sulfur proteins, other iron containing proteins - Dr. Pandur Edina
• 4. Microbial Iron Transport and Metabolism - Jánosa Gergely
• 5. Iron Acquisition by pathogens - Jánosa Gergely
• 6. Iron metabolism of yeasts - Pap Ramóna
• 7. Iron uptake by plants - Dr. Pandur Edina
• 8. Iron homeostasis in plants - Dr. Pandur Edina
• 9. Cellular Iron Uptake and Export in Mammals: iron transporters - Dr. Pandur Edina
• 10. Mammalian intestinal iron absorption - Dr. Pandur Edina
• 11. Intracellular Iron Storage - Dr. Pandur Edina
• 12. Intracellular Iron Metabolism and Cellular Iron Homeostasis I: Labile iron pool, mitochondrial iron uptake and metabolism haem biosynthesis - Pap Ramóna
• 13. Intracellular Iron Metabolism and Cellular Iron Homeostasis II: synthesis of iron-sulfur clusters, functions of iron responsive elements and iron regulatory proteins - Pap Ramóna
• 14. Regulation of Systemic Iron Metabolism: positive regulators of hepcidin - Dr. Pandur Edina
• 15. Regulation of Systemic Iron Metabolism: negative regulators of hepcidin - Dr. Pandur Edina
• 16. Pathophysiology of Iron metabolism: anemias (IDA, IRIDA, ACD) - Pap Ramóna
• 17. Pathophysiology of Iron metabolism: thalassemias and secondary iron overload - Jánosa Gergely
• 18. Pathophysiology of Iron metabolism: hemochromatosis - Dr. Pandur Edina
• 19. Pathophysiology of Iron metabolism: therapeutic approaches - Pap Ramóna
• 20. Iron disorders and Laboratory parameters 1. - Dr. Pandur Edina
• 21. Iron disorders and Laboratory parameters 2. - Dr. Pandur Edina
• 22. Iron and oxidative stress - Dr. Pandur Edina
• 23. Iron and immunity 1. - Pap Ramóna
• 24. Iron and immunity 2. - Pap Ramóna
• 25. Brain iron metabolism - Dr. Pandur Edina
• 26. The role of iron in neurodegenerative diseases - Dr. Pandur Edina
• 27. Iron and cancer 1. - Dr. Pandur Edina
• 28. Iron and cancer 2. - Dr. Pandur Edina

Practices

Seminars

Reading material

Obligatory literature

Literature developed by the Department

The lectures will be uploaded to the Neptun Meet street.

Notes

Recommended literature

Robert Crichton: Iron metabolism 4th Edition
Sarika Arora: Iron metabolism

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

Three midterm exams (tests), one possibility for retake.

Making up for missed classes

Personal consultation

Exam topics/questions

The questions will be formed from the learning material of the lectures.

Examiners

Instructor / tutor of practices and seminars