Iron Metabolism: from Molecular Mechanisms to Clinical Consequences

Adatok

A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2023-2024

Tematika

During the course we will discuss the role of iron in the metabolism. We will deal with the iron demand of microorganisms and with the role of iron in the protective mechanisms against bacterial infections. We will discuss the possibilities of iron uptake and intracellular iron utilistaion, especially heme synthesis, and the syntesis of iron-sulfur clusters. The iron storage and iron mobilization from stores will be discussed in details. We reveal the functions of iron regulatory factors, their crosstalks, and the functions of the iron-containing proteins. Based on the brand new literature we discuss the the positive and negative regulators of the master iron regulator hepcidin. During the course we will deal with the different types of iron disorders and diseases (anemias, thalassemias, secondary iron overload, hemochromatosis) their genetic background, and therapeutic approaches. Based on the most actual findings the role of iron in the developpment of neurodegenerative diseases (Parkinson's disease, Alzheimer's disease and Huntington's disease) will be also discussed.

Előadások

• 1. Solution chemistry of iron - Jánosa Gergely
• 2. Interactions between iron other metal ions - Jánosa Gergely
• 3. The Importance of Iron for Biological Systems: haemoproteins, iron-sulfur proteins, other iron containing proteins - Dr. Pandur Edina
• 4. Microbial Iron Transport and Metabolism - Jánosa Gergely
• 5. Iron Acquisition by pathogens - Jánosa Gergely
• 6. Iron metabolism of yeasts - Pap Ramóna
• 7. Iron uptake by plants - Dr. Pandur Edina
• 8. Iron homeostasis in plants - Dr. Pandur Edina
• 9. Cellular Iron Uptake and Export in Mammals: iron transporters - Dr. Pandur Edina
• 10. Mammalian intestinal iron absorption - Dr. Pandur Edina
• 11. Intracellular Iron Storage - Dr. Pandur Edina
• 12. Intracellular Iron Metabolism and Cellular Iron Homeostasis I: Labile iron pool, mitochondrial iron uptake and metabolism haem biosynthesis - Pap Ramóna
• 13. Intracellular Iron Metabolism and Cellular Iron Homeostasis II: synthesis of iron-sulfur clusters, functions of iron responsive elements and iron regulatory proteins - Pap Ramóna
• 14. Regulation of Systemic Iron Metabolism: positive regulators of hepcidin - Dr. Pandur Edina
• 15. Regulation of Systemic Iron Metabolism: negative regulators of hepcidin - Dr. Pandur Edina
• 16. Pathophysiology of Iron metabolism: anemias (IDA, IRIDA, ACD) - Pap Ramóna
• 17. Pathophysiology of Iron metabolism: thalassemias and secondary iron overload - Jánosa Gergely
• 18. Pathophysiology of Iron metabolism: hemochromatosis - Dr. Pandur Edina
• 19. Pathophysiology of Iron metabolism: therapeutic approaches - Pap Ramóna
• 20. Iron disorders and Laboratory parameters 1. - Dr. Pandur Edina
• 21. Iron disorders and Laboratory parameters 2. - Dr. Pandur Edina
• 22. Iron and oxidative stress - Dr. Pandur Edina
• 23. Iron and immunity 1. - Pap Ramóna
• 24. Iron and immunity 2. - Pap Ramóna
• 25. Brain iron metabolism - Dr. Pandur Edina
• 26. The role of iron in neurodegenerative diseases - Dr. Pandur Edina
• 27. Iron and cancer 1. - Dr. Pandur Edina
• 28. Iron and cancer 2. - Dr. Pandur Edina

Gyakorlatok

Szemináriumok

A tananyag elsajátításához szükséges segédanyagok

Kötelező irodalom

Saját oktatási anyag

The lectures will be uploaded to the Neptun Meet street.

Jegyzet

Ajánlott irodalom

Robert Crichton: Iron metabolism 4th Edition
Sarika Arora: Iron metabolism

A félév elfogadásának feltételei

Maximum of 25 % absence allowed

Félévközi ellenőrzések

Three midterm exams (tests), one possibility for retake.

Távolmaradás pótlásának lehetőségei

Personal consultation

Vizsgakérdések

The questions will be formed from the learning material of the lectures.

Vizsgáztatók

Gyakorlatok, szemináriumok oktatói