Pharmacodynamics 1 - Practice

Daten

Offizielle Daten in der Fachveröffentlichung für das folgende akademische Jahr: 2022-2023

Thematik

The aim of the course is to provide the students with the pharmacological knowledge required for their future work in the field of pharmacy. Important topics are the general principles of pharmacodynamics and pharmacokinetics.

Vorlesungen

Praktika

• 1. Introduction to pharmacodynamics I.
• 2. Introduction to pharmacodynamics II.
• 3. Basic mechanisms of drug actions
• 4. Characterization of the agonist-receptor interaction I.
• 5. Characterization of the agonist-receptor interaction II.
• 6. Characterization of the agonist-receptor interaction III.
• 7. Signal transduction mechanisms of drug receptors
• 8. Tachyphylaxis and tolerance
• 9. Mechanisms of drug antagonisms I.
• 10. Mechanisms of drug antagonisms II.
• 11. Transport of drugs across membranes
• 12. Absorption of drugs I.
• 13. Absorption of drugs II. Binding of drugs to plasma proteins
• 14. Distribution of drugs
• 15. Biotransformation of drugs I.
• 16. Biotransformation of drugs II.
• 17. Biotransformation of drugs III.
• 18. Excretion of drugs
• 19. Pharmacokinetic parameters I.
• 20. Pharmacokinetic parameters II.
• 21. Local anesthetics I.
• 22. Local anesthetics II.
• 23. Drugs acting on autonomic ganglia
• 24. Theoretical basis of the modulation of the pharmacology of the automatic nervous system
• 25. Analysis of the effects of drugs acting on the autonomic nervous system using computer simulation I.
• 26. Analysis of the effects of drugs acting on the autonomic nervous system using computer simulation II.
• 27. Discussion of the pharmacology of the autonomic nervous system I.
• 28. Discussion of the pharmacology of the autonomic nervous system II.

Seminare

Materialien zum Aneignen des Lehrstoffes

Obligatorische Literatur

Vom Institut veröffentlichter Lehrstoff

Electronic handouts are provided for most topics.

Skript

Empfohlene Literatur

Rang, Dale, Ritter, Moore: Pharmacology, 9th edition, Elsevier Churchill Livingstone, 2019
B. G. Katzung (ed.): Basic and Clinical Pharmacology, 14th edition, Lange Medical Books/McGraw-Hill, 2018

Voraussetzung zum Absolvieren des Semesters

Maximum of 25 % absence allowed

Semesteranforderungen

The students receive a practice grade based on their performance during the semester. The grade will be registered in the Neptun as a midsemester grade. The grade must be at least satisfactory as a prerequisite for taking the semester exam. Around the 11th week of the semester, a written test is the base of the practice grade. The test covers the subjects of practice classes of the first 10 weeks of the semester and 50% of the available points must be reached for acceptance of the semester. Should someone fail or want to improve, they can do it one time before the end of the semester. On a final failure (that is, after the improvement attempt still below 50%), the student cannot have semester accepted.

Möglichkeiten zur Nachholung der Fehlzeiten

There is no way to make up for missed classes.

Prüfungsfragen

1. Basic mechanisms of drug actions
2. Characterization of agonist-receptor interaction: occupancy, affinity, dose-response curve, potency, efficacy
3. Significance of signal transduction mechanisms in the effects of drugs. Tachyphylaxis and tolerance to drugs
4. Mechanisms of drug antagonisms
5. Transport of drugs across membranes
6. Absorption of drugs, oral bioavailability and presystemic elimination
7. Distribution of drugs
8. Biotransformation of drugs
9. Excretion of drugs
10. Quantitative pharmacokinetics: zero and first order elimination, volume of distribution, clearance, elimination half-life, oral bioavailability, calculation of loading and maintenance doses

Prüfer

Praktika, Seminarleiter/innen

• Dr. Barthó Loránd
• Dr. Kriszta Gábor
• Dr. Lemli Beáta
• Dr. Pethő Gábor István
• Dr. Poór Miklós
• Hartnerné Dr. Pohóczky Krisztina