Basic Immunology

Data

Official data in SubjectManager for the following academic year: 2024-2025

Topic

Introduction to the current immunobiology. Construction of the human immune system: organs, tissues, cellular and molecular components. Organisation and regulation of immune functions: recognition, differentiation, effector functions and memory formation. Main aspects of the physiological and pathological immune functions. Basic immunopathological aspects of immune related diseases including autoimmune diseases, organ transplantation, allergy, immunity against tumors.

Lectures

• 1. Introduction, phylogenesis of the immune system (innate-, adaptive- and natural immunity). - Boldizsár Ferenc
• 2. Composition of the immune system. Organs, tissues, cells, molecular components. - Boldizsár Ferenc
• 3. Mechanisms of innate immunity. Molecular and cellular components of inflammation (migration, phagocytosis, citokines, chemokines, adhesion molecules). - Engelmann Péter András
• 4. The complement system. - Berki Timea
• 5. Molecular components of the adaptive immune system.. Antigen recognition molecules: immunglobulins, B cell receptor, T cell receptor. - Boldizsár Ferenc
• 6. MHC and antigen presentation. - Boldizsár Ferenc
• 7. Communication among the cells of the immune system. Co-receptors and adhesion molecules. - Boldizsár Ferenc
• 8. The role of cytokines and cytokine receptors in the differentiation and function of immune cells. - Berki Timea
• 9. Primary lymphocyte differentiation in the bone marrow. - Boldizsár Ferenc
• 10. T cell maturation and selection in the thymus. - Boldizsár Ferenc
• 11. Beginning of the specific immune resoponse: T- and B cell acivation, T-dependent and T-independent antigens. - Boldizsár Ferenc
• 12. T cell polarization: differentiation of TH1/Th2, Treg/Th17, Tfh cells and their role in the physiological- and pathological immune response. - Boldizsár Ferenc
• 13. The central phase of the specific immune response: Extrafollicular reaction and processes in the germinal center (affinity maturation, isotype switch), antibody production. - Boldizsár Ferenc
• 14. Development and maintenance of the immunological memory, role in th immunological regulation. Comparison of the primary- and secondary immune response. - Boldizsár Ferenc
• 15. Immunglobulin-mediated effector functions. - Berki Timea
• 16. Participants of the cellular immune response (NK-, gamma/delta;- and cytotoxic T cells, macrophage activation) and their effector functions. - Berki Timea
• 17. Suppression of the immune response. - Kellermayer Zoltán
• 18. Local and systemic immunity. SALT, MALT. - Kellermayer Zoltán
• 19. Allergy and hypersensitivity. - Boldizsár Ferenc
• 20. Immunological tolerance and autoimmunity. - Boldizsár Ferenc
• 21. Immunodeficiencies. HIV infection and AIDS, Ebola. - Engelmann Péter András
• 22. Vaccinations and their mechanism of action. - Boldizsár Ferenc
• 23. Specific lymphatic tissue components of the oral cavity. Molecular and cellular elements of the oral defence system. - Kellermayer Zoltán
• 24. Immunological aspects of caries. - Kellermayer Zoltán
• 25. Immunology of periodontitis. - Boldizsár Ferenc
• 26. Immunological mechanisms of oral mucosa diseases. Tumor immunology. - Boldizsár Ferenc
• 27. Symptoms of congenital- and acquired immunodeficiencies in the oral cavity. - Boldizsár Ferenc
• 28. Transplantation. Immunological aspects of oral implantations. - Boldizsár Ferenc

Practices

Seminars

Reading material

Obligatory literature

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Literature developed by the Department

See on web site www.immbio.hu.

Notes

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Recommended literature

Abul K. Abbas: Cellular and Molecular Immunology

Janis Kuby: Immunology

Jan Klein: Immunology

Conditions for acceptance of the semester

Maximum 3 absences. Achieving minimum 50% on the tests during the semester.

Mid-term exams

Online testing will be performed their results will be considered for the acceptance of the semester as well as the exam results.

Making up for missed classes

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Exam topics/questions

See on web site www.immbio.hu.

Examiners

• Berki Timea
• Boldizsár Ferenc
• Engelmann Péter András
• Kellermayer Zoltán

Instructor / tutor of practices and seminars