Principles of Immunology

Data

Official data in SubjectManager for the following academic year: 2026-2027

Topic

Students participating in the course will get an overview of the most important aspects of basic immunology. We will introduce the tissue, cellular and molecular components of the immune network. The normal immune responses and regulatory mechanisms will be the focal point. Our aim is to provide a solid basis for the Applied Immunology subject coming in the second semester.

Lectures

• 1. Introduction. Components and structure of the immune network. Immunological recognition. - Boldizsár Ferenc
• 2. Structure of the lymphoid organs. - Erdő-Bonyár Szabina
• 3. Cells of the immune system, myeloid cells. - Erdő-Bonyár Szabina
• 4. Innate immunity. Pattern recognition. - Engelmann Péter András
• 5. Innate immunity. Inflammatory reaction. - Böröcz Katalin
• 6. Cells of the immune system, lymphoid cells. CD markers. - Erdő-Bonyár Szabina
• 7. Recognition molecules of the adaptive immune system: immunoglobulins. - Erdő-Bonyár Szabina
• 8. Recognition molecules of the adaptive immune system: T cell receptor. - Olasz Katalin Eszter
• 9. MHC and antigen presentation. - Olasz Katalin Eszter
• 10. Communication between the cells of the immune system. Cytokines. - Böröcz Katalin
• 11. Communication between the cells of the immune system. Adhesion molecules, coreceptors. - Böröcz Katalin
• 12. Organization and rearrangement of the antigen receptor genes. - Simon Diána
• 13. Primary B cell development: developmental stages and checkpoints. - Meggyes-Rapp Judit
• 14. T-cell development in the thymus. Stages of maturation and the role of environmental factors. - Ernszt Dávid
• 15. Beginning of the immune response: early stages of T/B cell interaction, CD3 complex and signal transduction, BcR signal transduction. Co-stimulation. T-dependent - Ernszt Dávid
• 16. Components of the humoral immune response: extrafollicular reaction and germinal center. - Simon Diána
• 17. Effector functions of immunoglobulins. Antigen-antibody reactions. - Olasz Katalin Eszter
• 18. The complement system - Olasz Katalin Eszter
• 19. Immunological memory. Comparison of the primary- and secondary immune responses. - Simon Diána
• 20. Principles of vaccinations. - Simon Diána
• 21.

  Effector mechanisms of cell-mediated immune responses: 1. Cytotoxicity, 2. Th cell-mediated macrophage activation (Delayed type hypersensitivity=DTH)

  - Olasz Katalin Eszter
• 22.

  Effector mechanisms of cell-mediated immune responses (NKT, MAIT)

  - Engelmann Péter András
• 23.

  Systemic and local immunity (SALT, MALT).

  - Meggyes-Rapp Judit
• 24.

  Suppression of the immune response.

  - Meggyes-Rapp Judit
• 25.

  Overview of Basic immunological methods: Principles of serological methods - agglutination, precipitation

  - Böröcz Katalin
• 26.

  Overview of Basic immunological methods: ELISA, ELISpot, dot blot and Western blot methodologies

  - Böröcz Katalin
• 27.

  Overview of Basic immunological methods: Immunohistology, immunofluorescence techniques, and multiplex immunoassays

  - Ernszt Dávid
• 28.

  Overview of Basic immunological methods: Flow cytometry and cell separation procedures

  - Ernszt Dávid

Practices

Seminars

Reading material

Obligatory literature

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Literature developed by the Department

All lectures will be available at www.immbio.hu.

Notes

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Recommended literature

Abul K. Abbas: Cellular and Molecular Immunology

Conditions for acceptance of the semester

Online test (moodle) on the second week. For students who achieve 75% or more, the course will be accepted.
On the midterm tests (moodle) minimum 50% must be achieved.
On the last lecture the students write a final test where minimum 60% must be achieved.

Mid-term exams

Midterm tests.

Making up for missed classes

None.

Exam topics/questions

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Examiners

Instructor / tutor of practices and seminars