Molecular Targets – Signal Transduction - Lecture

Data

Official data in SubjectManager for the following academic year: 2024-2025

Topic

Novel antibodies against receptors, protein kinase inhibitors, and antisense oligonucleotides targeting both signal transduction and gene expression will predominate the therapeutic approaches in the coming decades. The course focus on the therapeutic potential for targeting cell signaling mechanisms with particular attention to cancer therapies and inflammatory signaling pathways as well as immunomodulation. General concepts of inter-and intracellular signal transduction: receptor-mediated signal transduction, cell surface receptors, steroid hormone and nuclear receptors and their cytoplasmic signal transduction and nuclear responses, apoptotic cell signaling will be discussed together with the novel approaches to drug discovery in signal transduction.

Lectures

• 1. Introduction, overlap with other disciplines. - Boldizsár Ferenc
• 2. Overview of extracellular signaling. - Boldizsár Ferenc
• 3. Families of extracellular receptors. - Boldizsár Ferenc
• 4. Second messengers (cAMP). - Boldizsár Ferenc
• 5. Receptor tyrosine kinases. - Boldizsár Ferenc
• 6. The Ca2+ signal. - Boldizsár Ferenc
• 7. Transcription factors 1. - Boldizsár Ferenc
• 8. Transcription factors 2. - Boldizsár Ferenc
• 9. T cell activation and signaling. - Boldizsár Ferenc
• 10. Signaling in the specific immune system: B cell signaling. - Boldizsár Ferenc
• 11. Cytokine/chemokine signaling - Boldizsár Ferenc
• 12. Receptors with intrinsic enzymatic activity (insulin, growth factors). - Boldizsár Ferenc
• 13. G-protein-linked receptors (epinephrine, serotonin, glucagon). - Olasz Katalin Eszter
• 14. Signaling in tumor cells (EGF-R, Her-2R, adhesion molecules) 1. - Boldizsár Ferenc
• 15. Signaling in tumor cells (EGF-R, Her-2R, adhesion molecules) 2. - Boldizsár Ferenc
• 16. Intracellular/nuclear receptor signaling (steroid hormones and thyroxin). - Boldizsár Ferenc
• 17. Non-genomic steroid hormone signaling pathways. Receptor interactions, signaling cross-talk. - Boldizsár Ferenc
• 18. Apotosis signaling 1. - Boldizsár Ferenc
• 19. Apotosis signaling 2. - Boldizsár Ferenc
• 20. Fc gamma Receptor signaling - Berki Timea
• 21. Fc epsilon Receptor signaling - Berki Timea
• 22. Signaling in the innate immune system: CR signaling. - Olasz Katalin Eszter
• 23. Signaling in the innate immune system: TLR signaling. - Olasz Katalin Eszter
• 24. Signaling in the nervous system (Neurotransmitters). - Olasz Katalin Eszter
• 25. Ion channels. (Acetylcholine) - Boldizsár Ferenc
• 26. Wnt receptor signaling. - Boldizsár Ferenc
• 27. Pharmacological influence of the signaling 1. - Boldizsár Ferenc
• 28. Pharmacological influence of the signaling 2. - Boldizsár Ferenc

Practices

Seminars

Reading material

Obligatory literature

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Literature developed by the Department

www.immbio.hu

Notes

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Recommended literature

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Conditions for acceptance of the semester

none

Mid-term exams

none

Making up for missed classes

none

Exam topics/questions

The question on the exam are the same as the topics of the lectures.

Examiners

• Boldizsár Ferenc
• Olasz Katalin Eszter

Instructor / tutor of practices and seminars