Evolutionary Immunobiology


Official data in SubjectManager for the following academic year: 2023-2024

Course director

  • Dr. Péter András ENGELMANN

    associate professor,
    Department of Immunology and Biotechnology

Number of hours/semester

lectures: 0 hours

practices: 0 hours

seminars: 12 hours

total of: 12 hours

Subject data

  • Code of subject: OAF-EVO-T
  • 1 kredit
  • General Medicine
  • Optional modul
  • autumn

OAA-MB2-T completed , OAA-IMM-T completed

Course headcount limitations

min. 5 – max. 30

Available as Campus course for 30 fő számára. Campus-karok: ÁOK GYTK TTK


The course describes the molecular and cellular elements of innate/adaptive immunity in their evolutionary contexts. Moreover, it discusses the ancient immune functions (phagocytosis, antimicrobial molecules, antiviral RNA interference) along with the newest research data about the development of adaptive immunity.




  • 1. Definition of the topics and course, comparison of innate and adaptive immunity
  • 2. Pattern recognition receptors: Toll, Croquemort and others
  • 3. Conserved signal transduction pathways in immunology
  • 4. Cellular immune functions of innate immunity: phagocytosis, cytotoxicity, encapsulation-, capsule-, granulomeformation
  • 5. Humoral immune components I: antimicrobial molecules, peptides. Prophenoloxidase cascade, coagulation.
  • 6. Humoral immune components II: Acute-phase proteins, complement-evolution
  • 7. Humoral immune components III: evolution of cytokines and chemokines
  • 8. Sounds of Silence or the role of RNA interference (RNAi) in innate immunity, antiviral innate immunity
  • 9. Alternative adaptive immunity in invertebrates and in ancient vertebrates?
  • 10. Histoincompatibility in invertebrates, MHC-evolution
  • 11. Immunological twilight-zone - The appearance of adaptive immunity, Immunological triumvirate: RAG-time: immunglobulin, TCR development in the context of phylogenesis
  • 12. Phylogenetical development of vertebrate immune organs, host-pathogen co-evolution

Reading material

Obligatory literature

Literature developed by the Department



Recommended literature


Conditions for acceptance of the semester

Referral, max. 2 absences from the seminars

Mid-term exams


Making up for missed classes

Individual preparation

Exam topics/questions



Instructor / tutor of practices and seminars

  • Dr. Engelmann Péter András