Department of Immunology and Biotechnology · Subjects · Basic Immunology

Data

Official data in SubjectManager for the following academic year: 2023-2024

Course director

Dr. Ferenc BOLDIZSÁR

associate professor,
Department of Immunology and Biotechnology
boldizsar.ferenc@pte.hu

Number of hours/semester

lectures: 28 hours

practices: 0 hours

seminars: 0 hours

total of: 28 hours

Subject data

Code of subject: OSA-IMF-T
2 kredit
Dentistry
Basic modul
autumn

Prerequisites:

OSA-MF2-T completed , OSA-ZT1-T completed

Exam course:

yes

Course headcount limitations

min. 5 – max. 200

Available as Campus course for 127 fő számára. Campus-karok: ETK TTK

Topic

Introduction to the current immunobiology. Construction of the human immune system: organs, tissues, cellular and molecular components. Organisation and regulation of immune functions: recognition, differentiation, effector functions and memory formation. Main aspects of the physiological and pathological immune functions. Basic immunopathological aspects of immune related diseases including autoimmune diseases, organ transplantation, allergy, immunity against tumors.

Lectures

1. Introduction, phylogenesis of the immune system (innate-, adaptive- and natural immunity). - Dr. Boldizsár Ferenc
2. Composition of the immune system. Organs, tissues, cells, molecular components. - Dr. Boldizsár Ferenc
3. Mechanisms of innate immunity. Molecular and cellular components of inflammation (migration, phagocytosis, citokines, chemokines, adhesion molecules). - Dr. Engelmann Péter András
4. The complement system. - Dr. Berki Timea
5. Molecular components of the adaptive immune system.. Antigen recognition molecules: immunglobulins, B cell receptor, T cell receptor. - Dr. Boldizsár Ferenc
6. MHC and antigen presentation. - Dr. Boldizsár Ferenc
7. Communication among the cells of the immune system. Co-receptors and adhesion molecules. - Dr. Boldizsár Ferenc
8. The role of cytokines and cytokine receptors in the differentiation and function of immune cells. - Dr. Berki Timea
9. Primary lymphocyte differentiation in the bone marrow. - Dr. Boldizsár Ferenc
10. T cell maturation and selection in the thymus. - Dr. Boldizsár Ferenc
11. Beginning of the specific immune resoponse: T- and B cell acivation, T-dependent and T–independent antigens. - Dr. Boldizsár Ferenc
12. T cell polarization: differentiation of TH1/Th2, Treg/Th17, Tfh cells and their role in the physiological- and pathological immune response. - Dr. Boldizsár Ferenc
13. The central phase of the specific immune response: Extrafollicular reaction and processes in the germinal center (affinity maturation, isotype switch), antibody production. - Dr. Boldizsár Ferenc
14. Development and maintenance of the immunological memory, role in th immunological regulation. Comparison of the primary- and secondary immune response. - Dr. Boldizsár Ferenc
15. Immunglobulin-mediated effector functions. - Dr. Berki Timea
16. Participants of the cellular immune response (NK-, gamma/delta;- and cytotoxic T cells, macrophage activation) and their effector functions. - Dr. Berki Timea
17. Suppression of the immune response. - Dr. Kellermayer Zoltán
18. Local and systemic immunity. SALT, MALT. - Dr. Kellermayer Zoltán
19. Allergy and hypersensitivity. - Dr. Boldizsár Ferenc
20. Immunological tolerance and autoimmunity. - Dr. Boldizsár Ferenc
21. Immunodeficiencies. HIV infection and AIDS, Ebola. - Dr. Engelmann Péter András
22. Vaccinations and their mechanism of action. - Dr. Boldizsár Ferenc
23. Specific lymphatic tissue components of the oral cavity. Molecular and cellular elements of the oral defence system. - Dr. Kellermayer Zoltán
24. Immunological aspects of caries. - Dr. Kellermayer Zoltán
25. Immunology of periodontitis. - Dr. Boldizsár Ferenc
26. Immunological mechanisms of oral mucosa diseases. Tumor immunology. - Dr. Boldizsár Ferenc
27. Symptoms of congenital- and acquired immunodeficiencies in the oral cavity. - Dr. Boldizsár Ferenc
28. Transplantation. Immunological aspects of oral implantations. - Dr. Boldizsár Ferenc

Practices

Seminars

Reading material

Obligatory literature

Literature developed by the Department

See on web site www.immbio.hu.

Notes

Recommended literature

Abul K. Abbas: Cellular and Molecular Immunology
Janis Kuby: Immunology
Jan Klein: Immunology

Conditions for acceptance of the semester

Maximum 3 absences. Achieving minimum 50% on the tests during the lectures.

Mid-term exams

Online testing will be performed during the lectures and their results will be considered for the acceptance of the semester as well as the exam results.

Making up for missed classes

Exam topics/questions