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Student Researchers' Society Topics

A frequent model for the investigations of B-cell lymphomas relies on the studying of B-cell tumors in mice. We have identified in our department a novel spontaneous murine tumor displaying the characteristics of follicular lymphoma, which shows a preferential spreading via the lymphatic vessels. The aim of this project is to define the tissue partners of lymphoma cells and the signals providing survival stimuli.

Natural autoantibodies (nAAbs) are present in the serum of both healthy humans and patients suffering from systemic autoimmune diseases. nAAbs have been suggested to play a role in the primary immune response, furthermore, they play a role immune regulation. Within the framework of this research topic we are studying the network of nAAbs and infection –induced antibodies (iiA) in systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), systemic sclerosis, rheumatoid arthritis patients. In order to do so, we analyze the titers of anti- citrate synthase and anti-DNA topoisomerase-I antibodies, and compare these results to anti-viral antibody titers (induced by the MMR vaccine or natural infections) of routine laboratory samples (received from the Department of Rheumatology and Immunology; n= 420) of known clinical background.

Follicles in peripheral lymphoid organs (spleen, lymph nodes, etc.) play important roles in the survival of B cells and antibody-mediated immune responses, as well as in the propagation of B-cell malignancies and establishment of resistance to cytostatic therapy. In our studies we investigate the development of stromal cells and the developmental roles of B cells in vivo using  various mouse models.

Co-supervisor: Prof. Dr. BALOGH, Péter

Homing of regulatory T cells to the intestine is an important step in the development of tolerance against orally administered antigens (e.g. food proteins and commensal microbiota).  Homing to the intestine is mainly mediated by MAdCAM-1.  The object of the research is to investigate the effect of the absence of MAdCAM-1 on the inducibility of oral tolerance using various knockout mouse models.

Therapeutic depletion of various leukocyte subsets by monoclonal antibodies has become a routine clinical strategy; however, it is not known how its efficiency is modulated by the lymphoid microenvironment the target cells reside in. The aim of this study is to compare the efficiency of anti-T-cell monoclonal antibodies between various peripheral lymphoid tissues using mouse models, and to define how these tissue locations modulate the establishment of resistance against treatment.

The aim of this project is to establish a photoconversion procedure for the tracing of gut-associated leukocytes using Kikume transgenic mice, and applying to inflammatory bowel disease models.