Thermomania: the Medicine of Thermoregulation

Data

Official data in SubjectManager for the following academic year: 2024-2025

Topic

Maintenance of normal body temperature means life. Students applying for the course can learn the importance of temperature from the caveman till present days, they will get an insight into the mechanisms maintaining body temperature and into revolutionary theories of thermoregulation. They will hear how certain food ingredients (e.g., chili, menthol, etc.) influence body temperature, how thermoregulation differs between dinosaurs and humans and what are the subcellular heater units of our body. Based on the earned theoretical knowledge, students will then learn about extreme thermoregulatory disorders (e.g., hypothermia in high mountains, hibernation, etc.), furthermore, about the characteristics and peculiarities of the clinical appearance, diagnosis and therapy of thermoregulatory disorders in adult and childhood, in the form of clinical and pathophysiological case studies.

Lectures

• 1. The importance of temperature from the caveman till present and beyond. - Garami András
• 2. Proper techniques of temperature measurements: what should we pay attention to? - Garami András
• 3. 37 degrees Celsius: mechanisms of body temperature maintenance. - Garami András
• 4. Revolution in the field of thermoregulation. - Garami András
• 5. The role of chili, menthol, wasabi, cinnamon and their receptors in temperature regulation. - Garami András
• 6. Chili-pepper against obesity? Role of the capsaicin receptor in energy balance. - Garami András
• 7. Temperature maintenance from dinosaurs to humans: the evolution of thermoregulation. - Hoffmann Gyula
• 8. Microscopic heating units of the body: heat production in the mitochondria. - Hoffmann Gyula
• 9. Representative clinical cases of thermoregulatory disorders in adults I - Ruzsics István
• 10. Representative clinical cases of thermoregulatory disorders in adults II - Ruzsics István
• 11. Common clinical cases of fever in childhood I - Józsa Gergő
• 12. Common clinical cases of fever in childhood II - Józsa Gergő
• 13. Peculiar clinical cases of temperature regulation disorders I - Fehér Zsolt
• 14. Peculiar clinical cases of temperature regulation disorders II - Toldi János
• 15. Clinical cases of fever in urology I - Kenyeres Balázs
• 16. Clinical cases of fever in urology II - Kenyeres Balázs
• 17. Hotheaded, coldblooded: brain-teasing pathophysiological case studies I - Garami András
• 18. Hotheaded, coldblooded: brain-teasing pathophysiological case studies II - Garami András
• 19. Hibernation, hypothermia. - Garami András
• 20. Written exam - Garami András

Practices

Seminars

Reading material

Obligatory literature

Literature developed by the Department

Romanovsky AA: Thermoregulation: From Basic Neuroscience to Clinical Neurology. Handbook of Clinical Neurology Series. Elsevier, 2018.

A. Gomtsyan, C.R. Faltynek: Vanilloid Receptor TRPV1 in Drug Discovery, Wiley & Sons, 2010

www.FeverLab.net

Notes

Recommended literature

Conditions for acceptance of the semester

The absence rate is required to be kept under less than 25% of all lectures. At the end of the class students need to pass a multiple choice written test-exam.

Mid-term exams

Written exam

Making up for missed classes

Based upon individual agreements.

Exam topics/questions

Exam topics are the same as the topics of the lectures:

1. The importance of temperature from the caveman till present and beyond.

2. Proper techniques of temperature measurements: what should we pay attention to?

3. 37 degrees Celsius: mechanisms of body temperature maintenance.

4. Revolution in the field of thermoregulation.

5. The role of chili, menthol, wasabi, cinnamon and their receptors in temperature regulation.

6. Chili-pepper against obesity? Role of the capsaicin receptor in energy balance.

7. Temperature maintenance from dinosaurs to humans: the evolution of thermoregulation.

8. Microscopic heating units of the body: heat production in the mitochondria.

9. Feeding, as a heat generator.

10. Hypothermia in high mountains.

11. Representative clinical cases of thermoregulatory disorders in adults I.

12. Representative clinical cases of thermoregulatory disorders in adults II.

13. Common clinical cases of fever in childhood I.

14. Common clinical cases of fever in childhood II.

15. Peculiar clinical cases of temperature regulation disorders I.

16. Peculiar clinical cases of temperature regulation disorders II.

17. Clinical cases of fever in urology I.

18. Clinical cases of fever in urology II.

19. Hotheaded, coldblooded: brain-teasing pathophysiological case studies I.

20. Hotheaded, coldblooded: brain-teasing pathophysiological case studies II.

21. Hibernation, hypothermia.

22. Thermoregulation and its disorders in the elderly.

23. Multiple choice test-exam.

24. Multiple choice test-exam.

Examiners

• Garami András

Instructor / tutor of practices and seminars