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Pharmaceutical Chemistry 3 - Practice

Data

Official data in SubjectManager for the following academic year: 2026-2027

Course director

Number of hours/semester

lectures: 0 hours

practices: 42 hours

seminars: 0 hours

total of: 42 hours

Subject data

  • Code of subject: OPG-R3G_23-T
  • 3 kredit
  • Pharmacy
  • Pharmaceutical Science and Pharmacy modul
  • autumn semester
Prerequisites:

OPG-R2E-T finished

Exam course:

Course headcount limitations

min. 1 – max. 999

Topic

Introduction to the most important instrumental analytical methods and their applications to pharmacopoeal qualification of active pharmaceutical ingredients and excipients in pharamaceutical formulations.

Lectures

Practices

  • 1.

    Laboratory safety and accident protection.

    - Rozmer Zsuzsanna
  • 2.

    Method validation. Determination of sodium bicarbonate content according to Ph.Hg.VII. and Ph.Hg.VIII.

    - Rozmer Zsuzsanna
  • 3.

    Method validation. Determination of sodium bicarbonate content according to Ph.Hg.VII. and Ph.Hg.VIII.

    - Rozmer Zsuzsanna
  • 4.

    Validation of analytical methods. Statistical methods. Statistical evaluation of results obtained during the determination of sodium bicarbonate content.

    - Rozmer Zsuzsanna
  • 5.

    Validation of analytical methods. Statistical methods. Statistical evaluation of results obtained during the determination of sodium bicarbonate content.

    - Rozmer Zsuzsanna
  • 6.

    Validation of analytical methods. Statistical methods. Statistical evaluation of results obtained during the determination of sodium bicarbonate content.

    - Rozmer Zsuzsanna
  • 7.

    Applications of potentiometry I. Potentiometric endpoint detection. Determination of strong acid and weak acid side by side.

    - Rozmer Zsuzsanna
  • 8.

    Applications of potentiometry I. Potentiometric endpoint detection. Determination of strong acid and weak acid side by side.

    - Rozmer Zsuzsanna
  • 9.

    Applications of potentiometry I. Potentiometric endpoint detection. Determination of strong acid and weak acid side by side.

    - Rozmer Zsuzsanna
  • 10.

    The significance of the pKa value. Applications of potentiometry II. Potentiometric determination of the pKa value of weak acids and weak bases. Determination of the pKa value of ascorbic acid by potentiometric method.

    - Rozmer Zsuzsanna
  • 11.

    The significance of the pKa value. Applications of potentiometry II. Potentiometric determination of the pKa value of weak acids and weak bases. Determination of the pKa value of ascorbic acid by potentiometric method.

    - Rozmer Zsuzsanna
  • 12.

    The significance of the pKa value. Applications of potentiometry II. Potentiometric determination of the pKa value of weak acids and weak bases. Determination of the pKa value of ascorbic acid by potentiometric method.

    - Rozmer Zsuzsanna
  • 13.

    Application of UV spectrophotometry IV. Spectrophotometric determination of pKa values ​​of weak acids and weak bases. Calculation of pH-dependent relative concentration of particles. Determination of pKa value of benzocaine by spectrophotometric method.

    - Rozmer Zsuzsanna
  • 14.

    Application of UV spectrophotometry IV. Spectrophotometric determination of pKa values ​​of weak acids and weak bases. Calculation of pH-dependent relative concentration of particles. Determination of pKa value of benzocaine by spectrophotometric method.

    - Rozmer Zsuzsanna
  • 15.

    Application of UV spectrophotometry IV. Spectrophotometric determination of pKa values ​​of weak acids and weak bases. Calculation of pH-dependent relative concentration of particles. Determination of pKa value of benzocaine by spectrophotometric method.

    - Rozmer Zsuzsanna
  • 16.

    Application of IR spectroscopy, basics of spectrum evaluation. Evaluation of IR spectra of pharmaceutical materials. Pharmaceutical chemistry applications of NMR. Evaluation of 1H NMR spectra of pharmaceutical materials.

    - Rozmer Zsuzsanna
  • 17.

    Application of IR spectroscopy, basics of spectrum evaluation. Evaluation of IR spectra of pharmaceutical materials. Pharmaceutical chemistry applications of NMR. Evaluation of 1H NMR spectra of pharmaceutical materials.

    - Rozmer Zsuzsanna
  • 18.

    Application of IR spectroscopy, basics of spectrum evaluation. Evaluation of IR spectra of pharmaceutical materials. Pharmaceutical chemistry applications of NMR. Evaluation of 1H NMR spectra of pharmaceutical materials.

    - Rozmer Zsuzsanna
  • 19.

    Carbonic acid derivatives, Keto-enol and lactam-lactim tautomerism. Barbiturates. Urea, Hexobarbital (Ph. Hg. VII), Phenobarbital sodium (Ph. Hg. VII), Barbital sodium (Ph. Hg. VII).

    - Rozmer Zsuzsanna
  • 20.

    Carbonic acid derivatives, Keto-enol and lactam-lactim tautomerism. Barbiturates. Urea, Hexobarbital (Ph. Hg. VII), Phenobarbital sodium (Ph. Hg. VII), Barbital sodium (Ph. Hg. VII).

    - Rozmer Zsuzsanna
  • 21.

    Carbonic acid derivatives, Keto-enol and lactam-lactim tautomerism. Barbiturates. Urea, Hexobarbital (Ph. Hg. VII), Phenobarbital sodium (Ph. Hg. VII), Barbital sodium (Ph. Hg. VII).

    - Rozmer Zsuzsanna
  • 22.

    Drug stability studies. Investigation of the hydrolysis of acetylsalicylic acid.

    - Rozmer Zsuzsanna
  • 23.

    Drug stability studies. Investigation of the hydrolysis of acetylsalicylic acid.

    - Rozmer Zsuzsanna
  • 24.

    Drug stability studies. Investigation of the hydrolysis of acetylsalicylic acid.

    - Rozmer Zsuzsanna
  • 25.

    Application of mass spectrometry, basics of spectrum evaluation. Presentation of the instrument. Demonstration of a practical task.

    - Rozmer Zsuzsanna
  • 26.

    Application of mass spectrometry, basics of spectrum evaluation. Presentation of the instrument. Demonstration of a practical task.

    - Rozmer Zsuzsanna
  • 27.

    Application of mass spectrometry, basics of spectrum evaluation. Presentation of the instrument. Demonstration of a practical task.

    - Rozmer Zsuzsanna
  • 28.

    Acidum benzoicum, Acidum salicylicum, Acidum acetylsalicylicum. Natrii salicylas, Salicylamidum (Ph. Hg. VII).

    - Rozmer Zsuzsanna
  • 29.

    Acidum benzoicum, Acidum salicylicum, Acidum acetylsalicylicum. Natrii salicylas, Salicylamidum (Ph. Hg. VII).

    - Rozmer Zsuzsanna
  • 30.

    Acidum benzoicum, Acidum salicylicum, Acidum acetylsalicylicum. Natrii salicylas, Salicylamidum (Ph. Hg. VII).

    - Rozmer Zsuzsanna
  • 31.

    Azophenum, Noraminophenazonum, Aminophenazonum, Paracetamolum.

    - Rozmer Zsuzsanna
  • 32.

    Azophenum, Noraminophenazonum, Aminophenazonum, Paracetamolum.

    - Rozmer Zsuzsanna
  • 33.

    Azophenum, Noraminophenazonum, Aminophenazonum, Paracetamolum.

    - Rozmer Zsuzsanna
  • 34.

    Application of UV spectrophotometry. Side-by-side determination of salicylic acid and acetylsalicylic acid by spectrophotometric and alkalimetric methods.

    - Rozmer Zsuzsanna
  • 35.

    Application of UV spectrophotometry. Side-by-side determination of salicylic acid and acetylsalicylic acid by spectrophotometric and alkalimetric methods.

    - Rozmer Zsuzsanna
  • 36.

    Application of UV spectrophotometry. Side-by-side determination of salicylic acid and acetylsalicylic acid by spectrophotometric and alkalimetric methods.

    - Rozmer Zsuzsanna
  • 37.

    Application of HPLC in the analysis of drugs. Application of gas chromatography in the analysis of drugs.

    - Rozmer Zsuzsanna
  • 38.

    Application of HPLC in the analysis of drugs. Application of gas chromatography in the analysis of drugs.

    - Rozmer Zsuzsanna
  • 39.

    Application of HPLC in the analysis of drugs. Application of gas chromatography in the analysis of drugs.

    - Rozmer Zsuzsanna
  • 40.

    Preparing for the exam.

    - Rozmer Zsuzsanna
  • 41.

    Preparing for the exam.

    - Rozmer Zsuzsanna
  • 42.

    Preparing for the exam.

    - Rozmer Zsuzsanna

Seminars

Reading material

Obligatory literature

D.A. Williams, T.L. Lemke (eds.): Foye's Principles of Medicinal Chemistry, 7th edition, Lippincott Williams & Wilkins, Philadelphia, 2013

Literature developed by the Department

Attila Almási, Zsuzsanna Rozmer, Pál Perjési: Pharmaceutical Chemistry 1. Laboratory Experiments and Commentary, electronic educational material, PTE 2014

Notes

Pharmaceutical Chemistry Practice 1, laboratory manual, University of Pécs, 2015

Recommended literature

European Pharmacopoeia, EDQM Publication

Lecture notes.

Conditions for acceptance of the semester

Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the practices is obligatory. Maximum three absences can be accepted. Students have to write at least four short tests on the practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practice grade.

Mid-term exams

Students have to write at least four short tests on the practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practice grade.

Making up for missed classes

There is no opportunity to make up missed classes.

Exam topics/questions

The practical work (results of the written tests and the experimental work) is evaluated by a practice grade.

Examiners

Instructor / tutor of practices and seminars

  • Harmath Lilla Édua
  • Rozmer Zsuzsanna
  • Tyukodi Levente
Rólunk