Pharmaceutical Chemistry 3 - Practice

Adatok

A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2026-2027

Tematika

Introduction to the most important instrumental analytical methods and their applications to pharmacopoeal qualification of active pharmaceutical ingredients and excipients in pharamaceutical formulations.

Előadások

Gyakorlatok

• 1.

  Laboratory safety and accident protection.

  - Rozmer Zsuzsanna
• 2.

  Method validation. Determination of sodium bicarbonate content according to Ph.Hg.VII. and Ph.Hg.VIII.

  - Rozmer Zsuzsanna
• 3.

  Method validation. Determination of sodium bicarbonate content according to Ph.Hg.VII. and Ph.Hg.VIII.

  - Rozmer Zsuzsanna
• 4.

  Validation of analytical methods. Statistical methods. Statistical evaluation of results obtained during the determination of sodium bicarbonate content.

  - Rozmer Zsuzsanna
• 5.

  Validation of analytical methods. Statistical methods. Statistical evaluation of results obtained during the determination of sodium bicarbonate content.

  - Rozmer Zsuzsanna
• 6.

  Validation of analytical methods. Statistical methods. Statistical evaluation of results obtained during the determination of sodium bicarbonate content.

  - Rozmer Zsuzsanna
• 7.

  Applications of potentiometry I. Potentiometric endpoint detection. Determination of strong acid and weak acid side by side.

  - Rozmer Zsuzsanna
• 8.

  Applications of potentiometry I. Potentiometric endpoint detection. Determination of strong acid and weak acid side by side.

  - Rozmer Zsuzsanna
• 9.

  Applications of potentiometry I. Potentiometric endpoint detection. Determination of strong acid and weak acid side by side.

  - Rozmer Zsuzsanna
• 10.

  The significance of the pKa value. Applications of potentiometry II. Potentiometric determination of the pKa value of weak acids and weak bases. Determination of the pKa value of ascorbic acid by potentiometric method.

  - Rozmer Zsuzsanna
• 11.

  The significance of the pKa value. Applications of potentiometry II. Potentiometric determination of the pKa value of weak acids and weak bases. Determination of the pKa value of ascorbic acid by potentiometric method.

  - Rozmer Zsuzsanna
• 12.

  The significance of the pKa value. Applications of potentiometry II. Potentiometric determination of the pKa value of weak acids and weak bases. Determination of the pKa value of ascorbic acid by potentiometric method.

  - Rozmer Zsuzsanna
• 13.

  Application of UV spectrophotometry IV. Spectrophotometric determination of pKa values ​​of weak acids and weak bases. Calculation of pH-dependent relative concentration of particles. Determination of pKa value of benzocaine by spectrophotometric method.

  - Rozmer Zsuzsanna
• 14.

  Application of UV spectrophotometry IV. Spectrophotometric determination of pKa values ​​of weak acids and weak bases. Calculation of pH-dependent relative concentration of particles. Determination of pKa value of benzocaine by spectrophotometric method.

  - Rozmer Zsuzsanna
• 15.

  Application of UV spectrophotometry IV. Spectrophotometric determination of pKa values ​​of weak acids and weak bases. Calculation of pH-dependent relative concentration of particles. Determination of pKa value of benzocaine by spectrophotometric method.

  - Rozmer Zsuzsanna
• 16.

  Application of IR spectroscopy, basics of spectrum evaluation. Evaluation of IR spectra of pharmaceutical materials. Pharmaceutical chemistry applications of NMR. Evaluation of 1H NMR spectra of pharmaceutical materials.

  - Rozmer Zsuzsanna
• 17.

  Application of IR spectroscopy, basics of spectrum evaluation. Evaluation of IR spectra of pharmaceutical materials. Pharmaceutical chemistry applications of NMR. Evaluation of 1H NMR spectra of pharmaceutical materials.

  - Rozmer Zsuzsanna
• 18.

  Application of IR spectroscopy, basics of spectrum evaluation. Evaluation of IR spectra of pharmaceutical materials. Pharmaceutical chemistry applications of NMR. Evaluation of 1H NMR spectra of pharmaceutical materials.

  - Rozmer Zsuzsanna
• 19.

  Carbonic acid derivatives, Keto-enol and lactam-lactim tautomerism. Barbiturates. Urea, Hexobarbital (Ph. Hg. VII), Phenobarbital sodium (Ph. Hg. VII), Barbital sodium (Ph. Hg. VII).

  - Rozmer Zsuzsanna
• 20.

  Carbonic acid derivatives, Keto-enol and lactam-lactim tautomerism. Barbiturates. Urea, Hexobarbital (Ph. Hg. VII), Phenobarbital sodium (Ph. Hg. VII), Barbital sodium (Ph. Hg. VII).

  - Rozmer Zsuzsanna
• 21.

  Carbonic acid derivatives, Keto-enol and lactam-lactim tautomerism. Barbiturates. Urea, Hexobarbital (Ph. Hg. VII), Phenobarbital sodium (Ph. Hg. VII), Barbital sodium (Ph. Hg. VII).

  - Rozmer Zsuzsanna
• 22.

  Drug stability studies. Investigation of the hydrolysis of acetylsalicylic acid.

  - Rozmer Zsuzsanna
• 23.

  Drug stability studies. Investigation of the hydrolysis of acetylsalicylic acid.

  - Rozmer Zsuzsanna
• 24.

  Drug stability studies. Investigation of the hydrolysis of acetylsalicylic acid.

  - Rozmer Zsuzsanna
• 25.

  Application of mass spectrometry, basics of spectrum evaluation. Presentation of the instrument. Demonstration of a practical task.

  - Rozmer Zsuzsanna
• 26.

  Application of mass spectrometry, basics of spectrum evaluation. Presentation of the instrument. Demonstration of a practical task.

  - Rozmer Zsuzsanna
• 27.

  Application of mass spectrometry, basics of spectrum evaluation. Presentation of the instrument. Demonstration of a practical task.

  - Rozmer Zsuzsanna
• 28.

  Acidum benzoicum, Acidum salicylicum, Acidum acetylsalicylicum. Natrii salicylas, Salicylamidum (Ph. Hg. VII).

  - Rozmer Zsuzsanna
• 29.

  Acidum benzoicum, Acidum salicylicum, Acidum acetylsalicylicum. Natrii salicylas, Salicylamidum (Ph. Hg. VII).

  - Rozmer Zsuzsanna
• 30.

  Acidum benzoicum, Acidum salicylicum, Acidum acetylsalicylicum. Natrii salicylas, Salicylamidum (Ph. Hg. VII).

  - Rozmer Zsuzsanna
• 31.

  Azophenum, Noraminophenazonum, Aminophenazonum, Paracetamolum.

  - Rozmer Zsuzsanna
• 32.

  Azophenum, Noraminophenazonum, Aminophenazonum, Paracetamolum.

  - Rozmer Zsuzsanna
• 33.

  Azophenum, Noraminophenazonum, Aminophenazonum, Paracetamolum.

  - Rozmer Zsuzsanna
• 34.

  Application of UV spectrophotometry. Side-by-side determination of salicylic acid and acetylsalicylic acid by spectrophotometric and alkalimetric methods.

  - Rozmer Zsuzsanna
• 35.

  Application of UV spectrophotometry. Side-by-side determination of salicylic acid and acetylsalicylic acid by spectrophotometric and alkalimetric methods.

  - Rozmer Zsuzsanna
• 36.

  Application of UV spectrophotometry. Side-by-side determination of salicylic acid and acetylsalicylic acid by spectrophotometric and alkalimetric methods.

  - Rozmer Zsuzsanna
• 37.

  Application of HPLC in the analysis of drugs. Application of gas chromatography in the analysis of drugs.

  - Rozmer Zsuzsanna
• 38.

  Application of HPLC in the analysis of drugs. Application of gas chromatography in the analysis of drugs.

  - Rozmer Zsuzsanna
• 39.

  Application of HPLC in the analysis of drugs. Application of gas chromatography in the analysis of drugs.

  - Rozmer Zsuzsanna
• 40.

  Preparing for the exam.

  - Rozmer Zsuzsanna
• 41.

  Preparing for the exam.

  - Rozmer Zsuzsanna
• 42.

  Preparing for the exam.

  - Rozmer Zsuzsanna

Szemináriumok

A tananyag elsajátításához szükséges segédanyagok

Kötelező irodalom

D.A. Williams, T.L. Lemke (eds.): Foye's Principles of Medicinal Chemistry, 7th edition, Lippincott Williams & Wilkins, Philadelphia, 2013

Saját oktatási anyag

Attila Almási, Zsuzsanna Rozmer, Pál Perjési: Pharmaceutical Chemistry 1. Laboratory Experiments and Commentary, electronic educational material, PTE 2014

Jegyzet

Pharmaceutical Chemistry Practice 1, laboratory manual, University of Pécs, 2015

Ajánlott irodalom

European Pharmacopoeia, EDQM Publication

Lecture notes.

A félév elfogadásának feltételei

Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the practices is obligatory. Maximum three absences can be accepted. Students have to write at least four short tests on the practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practice grade.

Félévközi ellenőrzések

Students have to write at least four short tests on the practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practice grade.

Távolmaradás pótlásának lehetőségei

There is no opportunity to make up missed classes.

Vizsgakérdések

The practical work (results of the written tests and the experimental work) is evaluated by a practice grade.

Vizsgáztatók

Gyakorlatok, szemináriumok oktatói

• Harmath Lilla Édua
• Rozmer Zsuzsanna
• Tyukodi Levente