Department of Biochemistry and Medical Chemistry · Subjects · Medical Chemistry

Data

Official data in SubjectManager for the following academic year: 2024-2025

Course director

Takátsy Anikó

associate professor,
Department of Biochemistry and Medical Chemistry
aniko.takatsy@aok.pte.hu

Number of hours/semester

lectures: 42 hours

practices: 28 hours

seminars: 14 hours

total of: 84 hours

Subject data

Code of subject: OAA-ORK-T
6 kredit
General Medicine
Basic modul
autumn

Prerequisites:

Course headcount limitations

min. 5 – max. 300

Topic

Medical chemistry includes the topics of general chemistry which are necessary for medical students. It deals also with the chemistry of organic functional groups in a concise way. Majority of the curriculum deals with the bioorganic chemistry, which means the chemistry and descriptive biochemistry of biomolecules. The purpose of practices is to study some analytical chemistry and the knowledge of materials. Curriculum of medical chemistry contains the basic knowledge that is necessary to understand biochemistry, pharmacology and clinical chemistry. Medical Chemistry is a single semester subject concluding in an oral colloquium that is preceded by a written MRT of 10 explanatory questions, of which at least 70% should be scored.

Lectures

1. Introduction to Medical Chemistry - Takátsy Anikó
2. Structure of matter (atoms, ions, molecules, radicals) - Nagy Veronika
3. Intrduction to inorganic chemistry. Oxides, oxoacids, hydroxides, salts - Nagy Veronika
4. Molecular geometry, polarity, molecular interactions - Nagy Veronika
5. Introduction to organic chemistry. Nomenclatute, functional groups, Reaction types - Nagy Veronika
6. States of matter, gas laws. - Takátsy Anikó
7. Water and aqueous solutions. Concentration units. Colligative properties of dilute solutions. - Takátsy Anikó
8. Osmosis, composition of biofluids - Berente Zoltán
9. Equilibrium, the law of mass action, Le Chatelier principle - Takátsy Anikó
10. Role of electrolytes in living organisms, solubilty - Takátsy Anikó
11. Acids and bases, acid-base theories, acid-base reactions - Takátsy Anikó
12. Ion product constant of water, pH, pOH, hydrolysis of salts, pH-dependence of protonation - Takátsy Anikó
13. Buffer solutions - Takátsy Anikó
14. Buffer systems in living organisms - Berente Zoltán
15. Structure and formation of metal complexes. - Takátsy Anikó
16. Metal complexes in living organisms and in medical diagnosis - Berente Zoltán
17. Thermochemistry - Takátsy Anikó
18. Thermodynamics and the direction of chemical reactions - Nagy Veronika
19. Thermodynamics applied to living systems - Nagy Veronika
20. Reactionkinetics - Nagy Veronika
21. Steady-stateness, a characteristic of living systems - Nagy Veronika
22. Kinetic characteristics of cascade- and cyclic reactions - Nagy Veronika
23. Electrochemistry - Berente Zoltán
24. Electron transfer processes in living organisms - Berente Zoltán
25. Electrochemistry in the medical practice - Berente Zoltán
26. Basics of analytical chemistry for medical students - Takátsy Anikó
27. Basics of separation thechniques for medical students - Takátsy Anikó
28. Analitical instruments in medical diagnostics - Berente Zoltán
29. Introduction to organic chemistry - Nagy Veronika
30. Reaction types in organic chemistry - Nagy Veronika
31. Saturated hydrocarbons: Alkanes. Paraffins in medicine - Nagy Veronika
32. Unsaturated hydrocarbons: Alkenes and alkynes - Nagy Veronika
33. Isomerism among alkanes, cycloalkanes and alkenes - Nagy Veronika
34. Aromatic hydrocarbons. Organic halides - Nagy Veronika
35. Optical isomerism. Relative and absolute configuration. - Nagy Veronika
36. Aldehydes and their derivatives - Böddi Katalin
37. Ketones, quinones - Böddi Katalin
38. Amines and their biologically relevant derivatives - Böddi Katalin
39. Organic sulphur compounds, thioesthers - Nagy Veronika
40. Amines and their biologically relevant derivatives - Nagy Veronika
41. Colloid systems - Berente Zoltán
42. Colloid systems in living organisms - Berente Zoltán

Practices

1. Laboratory regulations. Accident and fire protection
2. Laboratory regulations. Accident and fire protection
3. Physical changes, phase transformations
4. Physical changes, phase transformations
5. Distillation, lyophilisation, rotational evaporation
6. Distillation, lyophilisation, rotational evaporation
7. Preparation of solutions
8. Preparation of solutions
9. Experiments with compounds of halogens and oxygen-group
10. Experiments with compounds of halogens and oxygen-group
11. Experiments with compounds nitrogen- and carbon group elements
12. Experiments with compounds nitrogen- and carbon group elements
13. Reactions of metalls and coordinative (complex) compounds.
14. Reactions of metalls and coordinative (complex) compounds.
15. Chemical equilibria, and salt hydrolysis
16. Chemical equilibria, and salt hydrolysis
17. Acid-base titration, buffer solutions
18. Acid-base titration, buffer solutions
19. Experiments in Electrochemistry
20. Experiments in Electrochemistry
21. Reaction kinetics
22. Reaction kinetics
23. Polarity, Chromatography
24. Polarity, Chromatography
25. Organic chemistry I. Reactions of functional groups I
26. Organic chemistry I. Reactions of functional groups I
27. Organic chemistry II. Reactions of functional groups II
28. Organic chemistry II. Reactions of functional groups II

Seminars

1. Basic concepts, stoichiometric calculations
2. Stoichiometric calculations
3. Geometry and polarity of molecules. Intermolecular interactions
4. Concentration of solutions
5. Inorganic Chemistry I
6. Inorganic Chemistry II
7. Metalls and coordinative chemistry
8. Chemical equilibria, salt hydrolysis
9. Acids, bases and pH
10. Electrochemistry
11. Reaction kinetics
12. Reactions in organic chemistry I
13. Reactions in organic chemistry II
14. Reactions in organic chemistry III

Reading material

Obligatory literature

Textbooks:

McMurray, Fay: Chemistry, latest edition

P. Gergely (ed.): Organic and Bioorganic Chemistry for Medical Students, latest edition, Univ. Med. School of Debrecen

Literature developed by the Department

Teams and Moodle:OAA-ORK-T-2023241-MEA-AORK-E

PotePedia

http://aok.pte.hu/en/egyseg/oktatasianyagok/20

Notes

Recommended literature

Veronika Nagy (ed.): Laboratory Experiments in Medical Chemistry, Internet edition, Univ. Med. School of Pécs, 2011

K. C. Timberlake: Chemistry - An Introduction to General, Organic and Biological Chemistry, latest edition

Conditions for acceptance of the semester

-Maximum 3 absences from 14 laboratory practices

-Submission of at least 10 from 12 laboratory tests (written on weeks 3-14)

-Achieving at least 7 exam points on 12 laboratory tests (written on weeks 3-14).

-Maximum 3 absences from 14 seminars

-Accomplishment of the criterion course (“General Chemistry”)

Mid-term exams

Seven laboratory practices on weeks 3-14 must be successfully accomplished (i.e. a successful lab test must be submitted at the beginning of the practice and a workbook, which is filled to a satisfactory extent and quality, must be submitted after the practice) in order to achieve the right to register for the exam. Students can achieve 1 or 0 exam points in the lab tests.

Seminars on weeks 3-14 start with a skills assessment test. Three assessment tests must be successful from each expected calculation and formula writing skills, otherwise the student will not be allowed to take the semester exam.

Make-up opportunities for lab tests and skills assessments will be provided in accordance with the Code of Studies and Examinations, during the exam period.

Making up for missed classes

None.

Exam topics/questions

Teams: OAA-ORK-T-2023241-MEA-AORK-E