Spectrometric Identification of Organic Compounds

Data

Official data in SubjectManager for the following academic year: 2024-2025

Topic

In this course students will be introduced to the theoretical bases and practice of the most frequently used spectroscopic methods in the determination of the structure of organic molecules, biomolecules and drugs. During the course students can acquire how to identify organic compounds from the complementary information afforded by three types of spectra: infrared, mass and NMR.

Lectures

Practices

Seminars

• 1. Infrared Spectroscopy: Introduction, theory, instrumentation, interpretation of spectra - Pápayné Sár Cecilia
• 2. Infrared Spectroscopy: Introduction, theory, instrumentation, interpretation of spectra - Pápayné Sár Cecilia
• 3. Infrared Spectroscopy: Characteristic group absorptions of organic molecules - Pápayné Sár Cecilia
• 4. Infrared Spectroscopy: Characteristic group absorptions of organic molecules - Pápayné Sár Cecilia
• 5. Infrared Spectroscopy: Solving problems - Pápayné Sár Cecilia
• 6. Infrared Spectroscopy: Solving problems - Pápayné Sár Cecilia
• 7. Proton Magnetic Resonance Spectrometry (1H NMR): Introduction, theory, instrumentation - Pápayné Sár Cecilia
• 8. Proton Magnetic Resonance Spectrometry (1H NMR): Introduction, theory, instrumentation - Pápayné Sár Cecilia
• 9. 1H NMR: Chemical shift, simple spin-spin coupling - Pápayné Sár Cecilia
• 10. 1H NMR: Chemical shift, simple spin-spin coupling - Pápayné Sár Cecilia
• 11. 1H NMR: Protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center - Pápayné Sár Cecilia
• 12. 1H NMR: Protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center - Pápayné Sár Cecilia
• 13. 13 C NMR Spectroscopy: Interpretation of 13 C spectra. The principles of MRI - Pápayné Sár Cecilia
• 14. 1H NMR and 13 C NMR: Solving problems - Pápayné Sár Cecilia
• 15. Mass Spectrometry: Mass spectrometer parts, ionization processes - Kálai Tamás
• 16. Mass Spectrometry: Mass spectrometer parts, ionization processes - Kálai Tamás
• 17. Mass Spectrometry: Appearance of the mass spectrum, mass spectra of classes of organic compounds - Kálai Tamás
• 18. Mass Spectrometry: Appearance of the mass spectrum, mass spectra of classes of organic compounds - Kálai Tamás
• 19. Mass Spectrometry: Interpretation of the mass spectrum through examples - Kálai Tamás
• 20. Mass Spectrometry: Interpretation of the mass spectrum through examples - Kálai Tamás
• 21. Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra - Pápayné Sár Cecilia
• ...

  22. Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra - Pápayné Sár Cecilia

  23. Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra - Pápayné Sár Cecilia

  24. Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra - Pápayné Sár Cecilia

  25. Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra - Pápayné Sár Cecilia
• 26. Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra - Pápayné Sár Cecilia
• 27. Evaluation, written test - Pápayné Sár Cecilia
• 28. Evaluation, written test - Pápayné Sár Cecilia

Reading material

Obligatory literature

Silverstein, R.M., Webster, F.X., Kiemle, D.: Spectrometric Identification of Organic Compounds, John Wiley and Sons, 2005.

Literature developed by the Department

The ppt slides are uploaded to Neptun Meet Street or TEAMS.

Notes

Recommended literature

Conditions for acceptance of the semester

Completing the written exam over 50%.

Mid-term exams

The student who has been absent from more than 25 % of the classes cannot be granted to entry of exam.

Making up for missed classes

Students can personally consult with the lecturer.

Exam topics/questions

Infrared Spectroscopy: theory, instrumentation, interpretation of spectra, chacteristic group absorptions of organic molecules.

Proton Magnetic Resonance Spectrometry (1H NMR): theory, instrumentation, chemical shift, simple spin-spin coupling, protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center.

Mass Spectrometry: mass spectrometer parts, ionization processes, appearance of the mass spectrum, mass spectra of classes of organic compounds.

Identification of simple organic molecules from IR, NMR and mass spectra.

Examiners

Instructor / tutor of practices and seminars

• Kálai Tamás
• Pápayné Sár Cecilia