Spectrometric Identification of Organic Compounds

Data

Official data in SubjectManager for the following academic year: 2023-2024

Topic

In this course students will be introduced to the theoretical bases and practice of the most frequently used spectroscopic methods in the determination of the structure of organic molecules, biomolecules and drugs. During the course students can acquire how to identify organic compounds from the complementary information afforded by three types of spectra: infrared, mass and NMR.

Lectures

Practices

Seminars

• 1. Infrared Spectroscopy: Introduction, theory, instrumentation, interpretation of spectra
• 2. Infrared Spectroscopy: Introduction, theory, instrumentation, interpretation of spectra
• 3. Infrared Spectroscopy: Characteristic group absorptions of organic molecules
• 4. Infrared Spectroscopy: Characteristic group absorptions of organic molecules
• 5. Infrared Spectroscopy: Solving problems
• 6. Infrared Spectroscopy: Solving problems
• 7. Proton Magnetic Resonance Spectrometry (1H NMR): Introduction, theory, instrumentation
• 8. Proton Magnetic Resonance Spectrometry (1H NMR): Introduction, theory, instrumentation
• 9. 1H NMR: Chemical shift, simple spin-spin coupling
• 10. 1H NMR: Chemical shift, simple spin-spin coupling
• 11. 1H NMR: Protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center
• 12. 1H NMR: Protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center
• 13. 13 C NMR Spectroscopy: Interpretation of 13 C spectra. The principles of MRI
• 14. 1H NMR and 13 C NMR: Solving problems
• 15. Mass Spectrometry: Mass spectrometer parts, ionization processes
• 16. Mass Spectrometry: Mass spectrometer parts, ionization processes
• 17. Mass Spectrometry: Appearance of the mass spectrum, mass spectra of classes of organic compounds
• 18. Mass Spectrometry: Appearance of the mass spectrum, mass spectra of classes of organic compounds
• 19. Mass Spectrometry: Interpretation of the mass spectrum through examples
• 20. Mass Spectrometry: Interpretation of the mass spectrum through examples
• 21. Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra
• 22. Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra
• 23. Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra
• 24. Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra
• 25. Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra
• 26. Summary of spectroscopic methods: identification of organic molecules from IR, NMR and mass spectra
• 27. Evaluation, written test
• 28. Evaluation, written test

Reading material

Obligatory literature

Silverstein, R.M., Webster, F.X., Kiemle, D.: Spectrometric Identification of Organic Compounds, John Wiley and Sons, 2005.

Literature developed by the Department

The ppt slides are uploaded to Neptun Meet Street.

Notes

Recommended literature

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

The student who has been absent from more than 25 % of the classes cannot be granted to entry of exam.

Making up for missed classes

Students can personally consult with the lecturer.

Exam topics/questions

Infrared Spectroscopy: theory, instrumentation, interpretation of spectra, chacteristic group absorptions of organic molecules.
Proton Magnetic Resonance Spectrometry (1H NMR): theory, instrumentation, chemical shift, simple spin-spin coupling, protons on heteroatoms, chemical shift equivalence and magnetic equivalence, effects of a chiral center.
Mass Spectrometry: mass spectrometer parts, ionization processes, appearance of the mass spectrum, mass spectra of classes of organic compounds.
Identification of simple organic molecules from IR, NMR and mass spectra.

Examiners

Instructor / tutor of practices and seminars

• Dr. Kálai Tamás
• Pápayné Dr. Sár Cecilia