Weak Molecular Interactions

Data

Official data in SubjectManager for the following academic year: 2023-2024

Topic

The complex biochemical equilibria in living bodies as reversible chemical reactions are based on a series of weak molecular interactions. Those interactions are playing very important role in the transfers of such bioactive molecules like the drugs and toxins. Further to this, the weak molecular interactions also play important role in the molecular packing, molecular formulation of medicines. The weak character of these interactions resulted that both the molecular environment and the temperature has high impact on these interactions. The temperature itself affects the efficiency of drugs through affecting the transfer and the drug – target interactions. Therefore detailed description of the temperature dependence of weak interactions is very important also in the associated therapies. Students will become acquainted through several newest research results with the pharmaceutical applications of the processes listed above and with the associated measuring methods and equipments.

Lectures

• 1. Types of molecular interactions. - Dr. Kunsági-Máté Sándor
• 2. Types of molecular interactions. - Dr. Kunsági-Máté Sándor
• 3. Chemical equilibrium based on the weak molecular interactions. - Dr. Kunsági-Máté Sándor
• 4. Chemical equilibrium based on the weak molecular interactions. - Dr. Kunsági-Máté Sándor
• 5. Determination of the chemical equilibrium and the stoichiometry of the complexes. - Dr. Kunsági-Máté Sándor
• 6. Determination of the chemical equilibrium and the stoichiometry of the complexes. - Dr. Kunsági-Máté Sándor
• 7. Correlation between the chemical equilibrium and the free enthalpy. - Dr. Kunsági-Máté Sándor
• 8. Correlation between the chemical equilibrium and the free enthalpy. - Dr. Kunsági-Máté Sándor
• 9. Investigation of the weak interaction by measuring the fluorescence. - Dr. Kunsági-Máté Sándor
• 10. Investigation of the weak interaction by measuring the fluorescence. - Dr. Kunsági-Máté Sándor
• 11. Application of the Job's method in the fluorescence measurements. - Dr. Kunsági-Máté Sándor
• 12. Application of the Job's method in the fluorescence measurements. - Dr. Kunsági-Máté Sándor
• 13. Direct measuring the interaction enthalpy by differential scanning calorimetry. - Dr. Kunsági-Máté Sándor
• 14. Direct measuring the interaction enthalpy by differential scanning calorimetry. - Dr. Kunsági-Máté Sándor
• 15. Interactions of aromatic compounds. Interactions of bioactive compounds with DNA. - Dr. Kunsági-Máté Sándor
• 16. Interactions of aromatic compounds. Interactions of bioactive compounds with DNA. - Dr. Kunsági-Máté Sándor
• 17. Investigations of model-systems: interactions of calixarenes with phenols and fullerenes. - Dr. Kunsági-Máté Sándor
• 18. Investigations of model-systems: interactions of calixarenes with phenols and fullerenes. - Dr. Kunsági-Máté Sándor
• 19. Investigations of the conformation changes of proteins by fluorescence and calorimetric methods. - Dr. Kunsági-Máté Sándor
• 20. Investigations of the conformation changes of proteins by fluorescence and calorimetric methods. - Dr. Kunsági-Máté Sándor
• 21. Investigations of the conformation changes of proteins by fluorescence and calorimetric methods. - Dr. Kunsági-Máté Sándor
• 22. Controlling of self-assembly of some hormones by weak interactions. - Dr. Kunsági-Máté Sándor
• 23. Controlling of self-assembly of some hormones by weak interactions. - Dr. Kunsági-Máté Sándor
• 24. Controlling of self-assembly of some hormones by weak interactions. - Dr. Kunsági-Máté Sándor
• 25. Modifications of structure of serum albumins by molecular capsules. Interactions of molecular capsules with aromatic amino acids at terminated positions. - Dr. Kunsági-Máté Sándor
• 26. Effect of Molecular Environment on the Formation Kinetics of Complexes of Malvidin-3-O-glucoside with Caffeic Acid and Catechin - Dr. Kunsági-Máté Sándor
• 27. Competitive hydrogen bonds associated with the effect of primycin antibiotic on oleic acid as a building block of plasma membranes.Complex formation between primycin and ergosterol: entropy - driven initiation of modification of the fungal plasma membrane structure - Dr. Kunsági-Máté Sándor
• 28. Role of the Conformational Freedom of the Skeleton in the Complex Formation Ability of Resorcinarene Derivatives toward a Neutral Phenol Guest - Dr. Kunsági-Máté Sándor

Practices

Seminars

Reading material

Obligatory literature

David Freifelder: Physical Biochemistry

Literature developed by the Department

Slides and notes of all lectures are available electronically. All topics discussed will be associated with papers published recently. Those papers together with the related doctoral dissertations in English will also be offered to support the teaching.

Notes

Recommended literature

Atkins: Physical Chemistry I-III.
David Freifelder: Physical Biochemistry

Conditions for acceptance of the semester

Maximum of 15 % absence allowed

Mid-term exams

One written exam during the semester, the acceptance level is 60%.

Making up for missed classes

There is no possibility to make up for a missed lecture and practice

Exam topics/questions

Types of molecular interactions.
Chemical equilibrium based on the weak molecular interactions.
Determination of the chemical equilibrium and the stoichiometry of the complexes.
Correlation between the chemical equilibrium and the Gibbs free energy.
Investigation of the weak interaction by spectroscopical methods.
Application of the Jobs method in the fluorescence measurements.
Direct measuring the interaction enthalpy by differential scanning calorimetry.
Interactions of aromatic compounds.
Interactions of bioactive compounds with DNA.
Investigations of model-systems: interactions of calixarenes with phenols and fullerenes.
Packing of drug molecules by molecular containers.
Interactions of bioactive molecules with elements of cell membranes.
Self-assembly of some hormones by weak interactions.

Examiners

Instructor / tutor of practices and seminars

• Dr. Kunsági-Máté Sándor