Student Researchers' Society Topics
The role of autoimmunity in complex regional pain syndrome and its experimental investigation in mice
Supervisor: HARTNERNÉ, Pohóczky Krisztina
Co-supervisor: Prof. Dr. HELYES, Zsuzsanna
Complex Regional Pain Syndrome (CRPS) is a multifactorial disease characterized by severe, persistent pain accompanied by abnormal hypersensitivity, swelling and autonomic alterations of the skin. Although theethiology is unknown, immune response against sensory nerve-derived antigens and complex neuro-immune interactions are suggested to be involved in the development of this disease. The therapy is still an unresolved problem, the importance of central versus peripheral sensitization mechanisms and peripheral inflammatory processes is unclear. In this student research topic our aim is to investigate the possible autoimmun and neuro-immun backgrounds of the disease, especially the role of interleukin and its receptors in the mouse model of CRPS developed and characterized by our reserach group.