Student Researchers' Society Topics
Investigation of the potential anxiolytic and antidepressant effects of dimethyltrisulfide via the endocannabinoid system in a mouse model of chronic unpredictable mild stress-induced anxiety and depression
Supervisor: POZSGAI, Gábor
Co-supervisor: GÖNTÉR, Kitti
In this topic we will study the effects of DMTS, an organic polysulphide, in a mouse model of anxiety and depression. Regarding the underlying mechanism, we investigate the endocannabinoid system. DMTS is likely to inhibit the main enzymes that degrade endocannabinoids by forming a disulfide bond with their cysteine side chains. Inhibition of these enzymes increases the endocannabinoid level in the CNS, reducing the effects of acute and chronic stress and the risk of depression.
Investigation of the transdermal pharmacokinetics of dimethyl trisulfide in mice
Supervisor: POZSGAI, Gábor
Co-supervisor: GÖNTÉR, Kitti
Investigation of transdermal dimethyl trisulfide absorption from solution, gel and patch formulations by HPLC