Optogenetics - The World of Proteins Controlled by Light

Daten

Offizielle Daten in der Fachveröffentlichung für das folgende akademische Jahr: 2021-2022

Thematik

Optogenetics refers to the intracellular use of photosensitive proteins that can be turned on or off using light to finely regulate specific biochemical processes.
This dynamically evolving revolutionary research method was first used by neuroscience in the early 2000s, but today, conquering several other fields of natural sciences, it can be found in basic biological, biophysical and biotechnological research as well as in many areas of medicine.
In order to demonstrate the extensive use of these proteins, we review the most well-known types of light-sensitive proteins, their mechanisms of action, and their biophysical characteristics. We then show, through a wealth of practical examples, how these proteins can be utilised. In addition to the methods used in basic research, we also focus on practical applications in medicine, primarily by presenting the latest advances in the treatment of certain diseases.

Vorlesungen

Praktika

Seminare

• 1. Introduction, general aspects of photo-responsive proteins
• 2. Opsins 1
• 3. Opsins 2
• 4. BLUF domains 1
• 5. BLUF domains 2
• 6. LOV domains 1
• 7. LOV domains 2
• 8. Fluorescent proteins
• 9. Cryptochromes 1
• 10. Cryptochromes 2
• 11. Biophysical aspects of the investigation of photo-responsive proteins
• 12. Test or presentation

Materialien zum Aneignen des Lehrstoffes

Obligatorische Literatur

Vom Institut veröffentlichter Lehrstoff

Will be published on Teams, Moodle or PotePedia.

Skript

Empfohlene Literatur

Voraussetzung zum Absolvieren des Semesters

Maximum of 25 % absence allowed

Semesteranforderungen

Will be published on Teams, Moodle or PotePedia.

Möglichkeiten zur Nachholung der Fehlzeiten

None

Prüfungsfragen

Will be published on Teams, Moodle or PotePedia.

Prüfer

Praktika, Seminarleiter/innen

• Dr. Fekete Zsuzsanna
• Dr. Lukács András Szilárd
• Pécsi Ildikó