The Medical Aspects of Human Population Genetics

Daten

Offizielle Daten in der Fachveröffentlichung für das folgende akademische Jahr: 2024-2025

Thematik

Throughout the course, we intend to give enlightenment regarding the practical side of detecting genetic differences between human populations therefore students may familiarize themselves with the conceptual background and medical aspects of the population genetics. The course also intends to show the relation between different disease spectrums and populations by international studies focusing on the detection of rare diseases, origin related researches, migration patterns and forensic medicine.

Vorlesungen

• 1. Introduction of Population Genetics - Bérczi Bálint Dániel
• 2. Historical background, basic principles - The Neo-Darwinian synthesis of evolution - Bérczi Bálint Dániel
• 3. Factors determining phenotype - Bérczi Bálint Dániel
• 4. Genotype, inherited epigenetic factors, non-inherited environmental factors - Bérczi Bálint Dániel
• 5. Genotype and allele frequencies - Bérczi Bálint Dániel
• 6. The Hardy-Weinberg principle with medical examples - Bérczi Bálint Dániel
• 7. The Four evolutionary Forces - Bérczi Bálint Dániel
• 8. Mutation - the Author of variation - Bérczi Bálint Dániel
• 9. Polymorphism - Single nucleotide polymorphisms (SNPs) and diseases - Bérczi Bálint Dániel
• 10. Allelic, dominant, recessive and codominant genetic models to associate SNPs with disease risk - Bérczi Bálint Dániel
• 11. Human Genome Project, The International HapMap Project, The 1000Genomes Project - Bérczi Bálint Dániel
• 12. Ethical issues of genotyping - Bérczi Bálint Dániel
• 13. Natural selection - the Editor - Bérczi Bálint Dániel
• 14. Genetic drift - the Randomizer - Bérczi Bálint Dániel
• 15. Gene flow - the Homogenizer - Bérczi Bálint Dániel
• 16. The genetic distance between ethnic groups and the mitochondrial Eve - Bérczi Bálint Dániel
• 17. Human origin related researches - The application of chromosome Y - Bérczi Bálint Dániel
• 18. Archeogenetics, microorganism related investigations in fossil bones and mummies - Bérczi Bálint Dániel
• 19. Application of population genetics in Forensic Medicine - Bérczi Bálint Dániel
• 20. Next generation sequencing technologies in Forensic Medicine - Bérczi Bálint Dániel
• 21. Various disease spectrums in various ethnic groups - Bérczi Bálint Dániel
• 22. The example of ethnic specific pattern of genetic variants in ESR1 and the risk of breast cancer - Bérczi Bálint Dániel
• 23. Research methodologies in population genetics - Bérczi Bálint Dániel
• 24. Methodology and possible workflows in studies, from planning to bioinformatics - Bérczi Bálint Dániel

Praktika

Seminare

Materialien zum Aneignen des Lehrstoffes

Obligatorische Literatur

Vom Institut veröffentlichter Lehrstoff

Lectures will be uploaded on Neptun.

Skript

Empfohlene Literatur

Genetics and Genomics. András Falus, Valéria László, Ferenc Oberfrank, Erna Pap, Dr. Csaba Szalai, Sára Tóth, Budapest University of Technology and Economics. https://edisciplinas.usp.br/pluginfile.php/5484931/mod_resource/content/1/REFERENCIA.1.pdf

Population Genetics, 2nd Edition by Matthew B. Hamilton

Voraussetzung zum Absolvieren des Semesters

exam

Semesteranforderungen

Written exam (simple choice) has to be done on the last lecture.

Möglichkeiten zur Nachholung der Fehlzeiten

There are no make-up classes.

Prüfungsfragen

Neptun

Prüfer

Praktika, Seminarleiter/innen