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Education

The Medical Aspects of Human Population Genetics

Data

Official data in SubjectManager for the following academic year: 2024-2025

Course director

Number of hours/semester

lectures: 24 hours

practices: 0 hours

seminars: 0 hours

total of: 24 hours

Subject data

  • Code of subject: OXF-PEG-h-T
  • 2 kredit
  • General Medicine
  • Optional modul
  • both
Prerequisites:

-

Course headcount limitations

min. 5 – max. 35

Available as Campus course for . Campus-karok: ÁOK GYTK TTK

Topic

Throughout the course, we intend to give enlightenment regarding the practical side of detecting genetic differences between human populations therefore students may familiarize themselves with the conceptual background and medical aspects of the population genetics. The course also intends to show the relation between different disease spectrums and populations by international studies focusing on the detection of rare diseases, origin related researches, migration patterns and forensic medicine.

Lectures

  • 1. Introduction of Population Genetics - Bérczi Bálint Dániel
  • 2. Historical background, basic principles - The Neo-Darwinian synthesis of evolution - Bérczi Bálint Dániel
  • 3. Factors determining phenotype - Bérczi Bálint Dániel
  • 4. Genotype, inherited epigenetic factors, non-inherited environmental factors - Bérczi Bálint Dániel
  • 5. Genotype and allele frequencies - Bérczi Bálint Dániel
  • 6. The Hardy-Weinberg principle with medical examples - Bérczi Bálint Dániel
  • 7. The Four evolutionary Forces - Bérczi Bálint Dániel
  • 8. Mutation - the Author of variation - Bérczi Bálint Dániel
  • 9. Polymorphism - Single nucleotide polymorphisms (SNPs) and diseases - Bérczi Bálint Dániel
  • 10. Allelic, dominant, recessive and codominant genetic models to associate SNPs with disease risk - Bérczi Bálint Dániel
  • 11. Human Genome Project, The International HapMap Project, The 1000Genomes Project - Bérczi Bálint Dániel
  • 12. Ethical issues of genotyping - Bérczi Bálint Dániel
  • 13. Natural selection - the Editor - Bérczi Bálint Dániel
  • 14. Genetic drift - the Randomizer - Bérczi Bálint Dániel
  • 15. Gene flow - the Homogenizer - Bérczi Bálint Dániel
  • 16. The genetic distance between ethnic groups and the mitochondrial Eve - Bérczi Bálint Dániel
  • 17. Human origin related researches - The application of chromosome Y - Bérczi Bálint Dániel
  • 18. Archeogenetics, microorganism related investigations in fossil bones and mummies - Bérczi Bálint Dániel
  • 19. Application of population genetics in Forensic Medicine - Bérczi Bálint Dániel
  • 20. Next generation sequencing technologies in Forensic Medicine - Bérczi Bálint Dániel
  • 21. Various disease spectrums in various ethnic groups - Bérczi Bálint Dániel
  • 22. The example of ethnic specific pattern of genetic variants in ESR1 and the risk of breast cancer - Bérczi Bálint Dániel
  • 23. Research methodologies in population genetics - Bérczi Bálint Dániel
  • 24. Methodology and possible workflows in studies, from planning to bioinformatics - Bérczi Bálint Dániel

Practices

Seminars

Reading material

Obligatory literature

Literature developed by the Department

Lectures will be uploaded on Neptun.

Notes

Recommended literature

Genetics and Genomics. András Falus, Valéria László, Ferenc Oberfrank, Erna Pap, Dr. Csaba Szalai, Sára Tóth, Budapest University of Technology and Economics. https://edisciplinas.usp.br/pluginfile.php/5484931/mod_resource/content/1/REFERENCIA.1.pdf

Population Genetics, 2nd Edition by Matthew B. Hamilton

Conditions for acceptance of the semester

exam

Mid-term exams

Written exam (simple choice) has to be done on the last lecture.

Making up for missed classes

There are no make-up classes.

Exam topics/questions

Neptun

Examiners

Instructor / tutor of practices and seminars

Rólunk